8AG6
human MutSalpha (MSH2/MSH6) binding to DNA with a GT mismatch
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA mismatch repair protein Msh2 | polymer | 934 | 104861.9 | 1 | UniProt (P43246) Pfam (PF01624) Pfam (PF05188) Pfam (PF05192) Pfam (PF05190) Pfam (PF00488) | Homo sapiens (human) | hMSH2,MutS protein homolog 2 |
| 2 | B (B) | DNA mismatch repair protein Msh6 | polymer | 1414 | 158767.3 | 1 | UniProt (P52701) Pfam (PF05190) Pfam (PF00488) Pfam (PF00855) Pfam (PF01624) Pfam (PF05188) Pfam (PF05192) | Homo sapiens (human) | hMSH6,G/T mismatch-binding protein,GTBP,GTMBP,MutS protein homolog 6,MutS-alpha 160 kDa subunit,p160 |
| 3 | C (E) | DNA (50-MER) | polymer | 50 | 15418.9 | 1 | synthetic construct | ||
| 4 | D (F) | DNA (50-MER) | polymer | 50 | 15402.9 | 1 | synthetic construct | ||
| 5 | E (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | F (A) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) |
Sequence modifications
B: 2 - 1360 (UniProt: P52701)
| PDB | External Database | Details |
|---|---|---|
| Met -53 | - | initiating methionine |
| Ala -52 | - | expression tag |
| His -51 | - | expression tag |
| His -50 | - | expression tag |
| His -49 | - | expression tag |
| His -48 | - | expression tag |
| His -47 | - | expression tag |
| His -46 | - | expression tag |
| His -45 | - | expression tag |
| His -44 | - | expression tag |
| His -43 | - | expression tag |
| His -42 | - | expression tag |
| Gly -41 | - | expression tag |
| Ser -40 | - | expression tag |
| Ala -39 | - | expression tag |
| Ala -38 | - | expression tag |
| Ser -37 | - | expression tag |
| Trp -36 | - | expression tag |
| Ser -35 | - | expression tag |
| His -34 | - | expression tag |
| Pro -33 | - | expression tag |
| Gln -32 | - | expression tag |
| Phe -31 | - | expression tag |
| Glu -30 | - | expression tag |
| Lys -29 | - | expression tag |
| Gly -28 | - | expression tag |
| Gly -27 | - | expression tag |
| Gly -26 | - | expression tag |
| Ser -25 | - | expression tag |
| Gly -24 | - | expression tag |
| Gly -23 | - | expression tag |
| Gly -22 | - | expression tag |
| Ser -21 | - | expression tag |
| Gly -20 | - | expression tag |
| Gly -19 | - | expression tag |
| Gly -18 | - | expression tag |
| Ser -17 | - | expression tag |
| Trp -16 | - | expression tag |
| Ser -15 | - | expression tag |
| His -14 | - | expression tag |
| Pro -13 | - | expression tag |
| Gln -12 | - | expression tag |
| Phe -11 | - | expression tag |
| Glu -10 | - | expression tag |
| Lys -9 | - | expression tag |
| Gly -8 | - | expression tag |
| Ala -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Glu -5 | - | expression tag |
| Val -4 | - | expression tag |
| Leu -3 | - | expression tag |
| Phe -2 | - | expression tag |
| Gln -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Pro 1 | - | expression tag |
| Glu 39 | Gly 39 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 294450.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 451.5 | |
| All* | Total formula weight | 294902.4 |
