6QML

UCHL3 in complex with synthetic, K27-linked diubiquitin

Summary for 6QML

Entry DOI	10.2210/pdb6qml/pdb
Descriptor	Ubiquitin carboxyl-terminal hydrolase isozyme L3, Polyubiquitin-B, Polyubiquitin-C, ... (8 entities in total)
Functional Keywords	deubiquitinase inhibition, protein binding, hydrolase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	87580.70
Authors	Murachelli, A.G.,Sixma, T.K. (deposition date: 2019-02-07, release date: 2020-02-26, Last modification date: 2024-01-24)
Primary citation	van Tilburg, G.B.A.,Murachelli, A.G.,Fish, A.,van der Heden van Noort, G.J.,Ovaa, H.,Sixma, T.K. K27-Linked Diubiquitin Inhibits UCHL3 via an Unusual Kinetic Trap. Cell Chem Biol, 28:191-201.e8, 2021 Cited by PubMed: 33238157 DOI: 10.1016/j.chembiol.2020.11.005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation