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5V59
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CRYSTAL STRUCTURE OF CATALYTIC FRAGMENT OF HUMAN ALARS IN COMPLEX WITH AZE-SA
Descriptor:Alanine--tRNA ligase, cytoplasmic, 5'-O-{[(2S)-azetidine-2-carbonyl]sulfamoyl}adenosine
Authors:Zhou, H., Song, Y., Schimmel, P.
Deposit date:2017-03-13
Release date:2018-01-10
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid.
Nat Commun, 8, 2017
5V58
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CRYSTAL STRUCTURE OF HUMAN PROLYL-TRNA SYNTHETASE IN COMPLEX WITH AZE-SA
Descriptor:Bifunctional glutamate/proline--tRNA ligase, 5'-O-{[(2S)-azetidine-2-carbonyl]sulfamoyl}adenosine, ZINC ION
Authors:Zhou, H., Song, Y., Schimmel, P.
Deposit date:2017-03-13
Release date:2018-01-10
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid.
Nat Commun, 8, 2017
5UJJ
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CRYSTAL STRUCTURE OF HUMAN H130R TRYPTOPHANYL-TRNA SYNTHETASE IN COMPLEX WITH TRPAMP
Descriptor:Tryptophan--tRNA ligase, cytoplasmic, TRYPTOPHANYL-5'AMP, ...
Authors:Xu, X., Yang, X.-L.
Deposit date:2017-01-18
Release date:2018-01-17
Last modified:2018-08-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:An alternative conformation of human TrpRS suggests a role of zinc in activating non-enzymatic function.
RNA Biol, 15, 2018
5UJI
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CRYSTAL STRUCTURE OF HUMAN T2-TRYPTOPHANYL-TRNA SYNTHETASE WITH H130R MUTATION
Descriptor:Tryptophan--tRNA ligase, cytoplasmic
Authors:Xu, X., Yang, X.-L.
Deposit date:2017-01-18
Release date:2018-01-17
Last modified:2018-08-29
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:An alternative conformation of human TrpRS suggests a role of zinc in activating non-enzymatic function.
RNA Biol, 15, 2018
5THL
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CRYSTAL STRUCTURE OF THE HUMAN TYROSYL-TRNA SYNTHETASE MUTANT G41R
Descriptor:Tyrosine--tRNA ligase, cytoplasmic
Authors:Blocquel, D., Sajish, M., Yang, X.L.
Deposit date:2016-09-29
Release date:2017-06-07
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy.
Nucleic Acids Res., 45, 2017
5THH
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CRYSTAL STRUCTURE OF A HUMAN TYROSYL-TRNA SYNTHETASE MUTANT
Descriptor:Tyrosine--tRNA ligase, cytoplasmic, TYROSINE
Authors:Blocquel, D., Yang, X.L.
Deposit date:2016-09-29
Release date:2017-05-17
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.959 Å)
Cite:Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy.
Nucleic Acids Res., 45, 2017
5T76
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A FRAGMENT OF A HUMAN TRNA SYNTHETASE
Descriptor:Alanine--tRNA ligase, cytoplasmic
Authors:Sun, L., Schimmel, P.
Deposit date:2016-09-02
Release date:2016-11-30
Last modified:2017-01-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5T5S
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A FRAGMENT OF A HUMAN TRNA SYNTHETASE
Descriptor:Alanine--tRNA ligase, cytoplasmic
Authors:Sun, L., Schimmel, P.
Deposit date:2016-08-31
Release date:2016-11-30
Last modified:2017-01-04
Method:X-RAY DIFFRACTION (2.202 Å)
Cite:Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5KNN
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EVOLUTIONARY GAIN OF ALANINE MISCHARGING TO NON-COGNATE TRNAS WITH A G4:U69 BASE PAIR
Descriptor:Alanine--tRNA ligase, cytoplasmic, '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE
Authors:Sun, L., He, W., Yang, X.-L.
Deposit date:2016-06-28
Release date:2016-09-28
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Evolutionary Gain of Alanine Mischarging to Noncognate tRNAs with a G4:U69 Base Pair.
J.Am.Chem.Soc., 138, 2016
5K9G
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CRYSTAL STRUCTURE OF GTP CYCLOHYDROLASE-IB WITH TRIS
Descriptor:GTP cyclohydrolase FolE2, ZINC ION, 1,2-ETHANEDIOL, ...
Authors:Alvarez, J., Stec, B., Swairjo, M.A.
Deposit date:2016-05-31
Release date:2016-09-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Zinc-independent folate biosynthesis: genetic, biochemical, and structural investigations reveal new metal dependence for GTP cyclohydrolase IB.
J.Bacteriol., 191, 2009
4QBT
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CRYSTAL STRUCTURE OF TYROSINE BOUND HUMAN TYROSYL TRNA SYNTHETASE
Descriptor:Tyrosine--tRNA ligase, cytoplasmic, PHOSPHATE ION, ...
Authors:Mathew, S., Schimmel, P.
Deposit date:2014-05-08
Release date:2014-12-17
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol.
Nature, 519, 2014
4Q93
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CRYSTAL STRUCTURE OF RESVERATROL BOUND HUMAN TYROSYL TRNA SYNTHETASE
Descriptor:Tyrosine--tRNA ligase, cytoplasmic, RESVERATROL, ...
Authors:Mathew, S., Schimmel, P.
Deposit date:2014-04-28
Release date:2014-12-17
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol.
Nature, 519, 2014
4HVC
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CRYSTAL STRUCTURE OF HUMAN PROLYL-TRNA SYNTHETASE IN COMPLEX WITH HALOFUGINONE AND ATP ANALOGUE
Descriptor:Bifunctional glutamate/proline--tRNA ligase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, ...
Authors:Zhou, H., Sun, L., Yang, X.L., Schimmel, P.
Deposit date:2012-11-06
Release date:2013-01-02
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase.
Nature, 494, 2012
4G85
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CRYSTAL STRUCTURE OF HUMAN HISRS
Descriptor:Histidine-tRNA ligase, cytoplasmic
Authors:Wei, Z., Wu, J., Zhou, J.J., Yang, X.-L., Zhang, M., Schimmel, P.
Deposit date:2012-07-21
Release date:2012-09-26
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:Internally Deleted Human tRNA Synthetase Suggests Evolutionary Pressure for Repurposing.
Structure, 20, 2012
4G84
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CRYSTAL STRUCTURE OF HUMAN HISRS
Descriptor:Histidine--tRNA ligase, cytoplasmic, IMIDAZOLE, ...
Authors:Wei, Z., Wu, J., Zhou, J.J., Yang, X.-L., Zhang, M., Schimmel, P.
Deposit date:2012-07-21
Release date:2012-09-26
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Internally Deleted Human tRNA Synthetase Suggests Evolutionary Pressure for Repurposing.
Structure, 20, 2012
4EQH
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CRYSTAL STRUCTURE OF HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 1 (HINT1) FROM HUMAN COMPLEXED WITH TRP-AMS
Descriptor:Histidine triad nucleotide-binding protein 1, 5'-O-[(L-TRYPTOPHYLAMINO)SULFONYL]ADENOSINE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Wang, J., Fang, P., Guo, M.
Deposit date:2012-04-18
Release date:2012-05-02
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.668 Å)
Cite:Side chain independent recognition of aminoacyl adenylates by the hint1 transcription suppressor.
J.Phys.Chem.B, 116, 2012
4EQG
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CRYSTAL STRUCTURE OF HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 1 (HINT1) FROM HUMAN COMPLEXED WITH ALA-AMS
Descriptor:Histidine triad nucleotide-binding protein 1, '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Wang, J., Fang, P., Guo, M.
Deposit date:2012-04-18
Release date:2012-05-02
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Side chain independent recognition of aminoacyl adenylates by the hint1 transcription suppressor.
J.Phys.Chem.B, 116, 2012
4EQE
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CRYSTAL STRUCTURE OF HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 1 (HINT1) FROM HUMAN COMPLEXED WITH LYS-AMS
Descriptor:Histidine triad nucleotide-binding protein 1, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-O-[(L-LYSYLAMINO)SULFONYL]ADENOSINE
Authors:Wang, J., Fang, P., Guo, M.
Deposit date:2012-04-18
Release date:2012-05-02
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Side chain independent recognition of aminoacyl adenylates by the hint1 transcription suppressor.
J.Phys.Chem.B, 116, 2012
4DPG
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CRYSTAL STRUCTURE OF HUMAN LYSRS: P38/AIMP2 COMPLEX I
Descriptor:Lysine--tRNA ligase, Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, LYSINE, ...
Authors:Fang, P., Wang, J., Bennett, S.P., Guo, M.
Deposit date:2012-02-13
Release date:2013-02-13
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.844 Å)
Cite:Structural Switch of Lysyl-tRNA Synthetase between Translation and Transcription.
Mol.Cell, 49, 2013
3WQZ
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CRYSTAL STRUCTURE OF ARCHAEOGLOBUS FULGIDUS ALANYL-TRNA SYNTHETASE IN COMPLEX WITH A TRNA(ALA) VARIANT HAVING A3.U70
Descriptor:Alanine--tRNA ligase, RNA (75-MER), '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE, ...
Authors:Naganuma, M., Sekine, S., Yokoyama, S.
Deposit date:2014-02-05
Release date:2014-06-18
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (3.489 Å)
Cite:The selective tRNA aminoacylation mechanism based on a single G.U pair
Nature, 510, 2014
3WQY
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CRYSTAL STRUCTURE OF ARCHAEOGLOBUS FULGIDUS ALANYL-TRNA SYNTHETASE IN COMPLEX WITH WILD-TYPE TRNA(ALA) HAVING G3.U70
Descriptor:Alanine--tRNA ligase, RNA (75-MER), '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE, ...
Authors:Naganuma, M., Sekine, S., Yokoyama, S.
Deposit date:2014-02-05
Release date:2014-06-18
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:The selective tRNA aminoacylation mechanism based on a single G.U pair
Nature, 510, 2014
3HY1
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CRYSTAL STRUCTURE OF CATALYTIC FRAGMENT OF E. COLI ALARS G237A IN COMPLEX WITH SERSA
Descriptor:Alanyl-tRNA synthetase, 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, 2-HYDROXYETHYL DISULFIDE, ...
Authors:Guo, M., Yang, X.-L., Schimmel, P.
Deposit date:2009-06-22
Release date:2009-12-15
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma.
Nature, 462, 2009
3HY0
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CRYSTAL STRUCTURE OF CATALYTIC FRAGMENT OF E. COLI ALARS G237A IN COMPLEX WITH GLYSA
Descriptor:Alanyl-tRNA synthetase, 5'-O-(glycylsulfamoyl)adenosine, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Guo, M., Yang, X.-L., Schimmel, P.
Deposit date:2009-06-22
Release date:2009-12-15
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma.
Nature, 462, 2009
3HXZ
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CRYSTAL STRUCTURE OF CATALYTIC FRAGMENT OF E. COLI ALARS G237A IN COMPLEX WITH ALASA
Descriptor:Alanyl-tRNA synthetase, '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Guo, M., Yang, X.-L., Schimmel, P.
Deposit date:2009-06-22
Release date:2009-12-15
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma.
Nature, 462, 2009
3HXY
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CRYSTAL STRUCTURE OF CATALYTIC FRAGMENT OF E. COLI ALARS IN COMPLEX WITH AMPPCP, ALA-AMP AND PCP
Descriptor:Alanyl-tRNA synthetase, 5'-O-[(R)-{[(2S)-2-aminopropanoyl]oxy}(hydroxy)phosphoryl]adenosine, METHYLENEDIPHOSPHONIC ACID, ...
Authors:Guo, M., Yang, X.-L., Schimmel, P.
Deposit date:2009-06-22
Release date:2009-12-15
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma.
Nature, 462, 2009
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