Author results

3JWD
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STRUCTURE OF HIV-1 GP120 WITH GP41-INTERACTIVE REGION: LAYERED ARCHITECTURE AND BASIS OF CONFORMATIONAL MOBILITY
Descriptor:HIV-1 GP120 ENVELOPE GLYCOPROTEIN, T-cell surface glycoprotein CD4, FAB 48D LIGHT CHAIN, ...
Authors:Pancera, M., Majeed, S., Ban, Y.A., Chen, L., Huang, C.C., Kong, L., Kwon, Y.D., Stuckey, J., Zhou, T., Robinson, J.E., Schief, W.R., Sodroski, J., Wyatt, R., Kwong, P.D.
Deposit date:2009-09-18
Release date:2009-12-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility.
Proc.Natl.Acad.Sci.USA, 107, 2010
3LES
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2F5 EPITOPE SCAFFOLD ES2
Descriptor:RNA polymerase sigma factor, SULFATE ION
Authors:Ofek, G., Guenaga, F.J., Schief, W.R., Skinner, J., Wyatt, R., Baker, D., Kwong, P.D.
Deposit date:2010-01-15
Release date:2010-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Elicitation of structure-specific antibodies by epitope scaffolds.
Proc.Natl.Acad.Sci.USA, 107, 2010
3LEV
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HIV-1 ANTIBODY 2F5 IN COMPLEX WITH EPITOPE SCAFFOLD ES2
Descriptor:RNA polymerase sigma factor, 2F5 ANTIBODY LIGHT CHAIN, 2F5 ANTIBODY HEAVY CHAIN, ...
Authors:Ofek, G., Guenaga, F.J., Schief, W.R., Skinner, J., Baker, D., Wyatt, R., Kwong, P.D.
Deposit date:2010-01-15
Release date:2010-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Elicitation of structure-specific antibodies by epitope scaffolds.
Proc.Natl.Acad.Sci.USA, 107, 2010
3LEX
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2F5 EPITOPE SCAFFOLD ELICITED ANTI-HIV-1 MONOCLONAL ANTIBODY 11F10 IN COMPLEX WITH HIV-1 GP41
Descriptor:11f10 Antibody Heavy Chain, 11f10 Antibody Light Chain, Envelope glycoprotein gp41
Authors:Ofek, G., Guenaga, F.J., Schief, W.R., Skinner, J., Baker, D., Wyatt, R., Kwong, P.D.
Deposit date:2010-01-15
Release date:2010-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Elicitation of structure-specific antibodies by epitope scaffolds.
Proc.Natl.Acad.Sci.USA, 107, 2010
3LEY
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2F5 EPITOPE SCAFFOLD ELICITED ANTI-HIV-1 MONOCLONAL ANTIBODY 6A7 IN COMPLEX WITH HIV-1 GP41
Descriptor:6a7 Antibody Heavy Chain, 6a7 Antibody Light Chain, Envelope glycoprotein gp41, ...
Authors:Ofek, G., Guenaga, F.J., Schief, W.R., Skinner, J., Baker, D., Wyatt, R., Kwong, P.D.
Deposit date:2010-01-15
Release date:2010-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Elicitation of structure-specific antibodies by epitope scaffolds.
Proc.Natl.Acad.Sci.USA, 107, 2010
3RFN
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EPITOPE BACKBONE GRAFTING BY COMPUTATIONAL DESIGN FOR IMPROVED PRESENTATION OF LINEAR EPITOPES ON SCAFFOLD PROTEINS
Descriptor:BB_1wnu_001, ZINC ION
Authors:Azoitei, M.L., Ban, Y.A., Julien, J.P., Bryson, S., Schroeter, A., Kalyuzhniy, O., Porter, J.R., Adachi, Y., Baker, D., Szabo, E., Pai, E.F., Schief, W.R.
Deposit date:2011-04-06
Release date:2011-11-09
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope.
J.Mol.Biol., 415, 2012
3RHU
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EPITOPE BACKBONE GRAFTING BY COMPUTATIONAL DESIGN FOR IMPROVED PRESENTATION OF LINEAR EPITOPES ON SCAFFOLD PROTEINS
Descriptor:SC_1wnu
Authors:Azoitei, M.L., Ban, Y.A., Julien, J.P., Bryson, S., Schroeter, A., Kalyuzhniy, O., Porter, J.R., Adachi, Y., Baker, D., Szabo, E., Pai, E.F., Schief, W.R.
Deposit date:2011-04-12
Release date:2011-11-09
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope.
J.Mol.Biol., 415, 2012
3RI0
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EPITOPE BACKBONE GRAFTING BY COMPUTATIONAL DESIGN FOR IMPROVED PRESENTATION OF LINEAR EPITOPES ON SCAFFOLD PROTEINS
Descriptor:BB_2cx5_001, GLYCEROL, SULFATE ION
Authors:Azoitei, M.L., Ban, Y.A., Julien, J.P., Bryson, S., Schroeter, A., Kalyuzhniy, O., Porter, J.R., Adachi, Y., Baker, D., Szabo, E., Pai, E.F., Schief, W.R.
Deposit date:2011-04-12
Release date:2011-11-09
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope.
J.Mol.Biol., 415, 2012
3RIJ
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EPITOPE BACKBONE GRAFTING BY COMPUTATIONAL DESIGN FOR IMPROVED PRESENTATION OF LINEAR EPITOPES ON SCAFFOLD PROTEINS
Descriptor:SC_2cx5, GLYCEROL
Authors:Azoitei, M.L., Ban, Y.A., Julien, J.P., Bryson, S., Schroeter, A., Kalyuzhniy, O., Porter, J.R., Adachi, Y., Baker, D., Szabo, E., Pai, E.F., Schief, W.R.
Deposit date:2011-04-13
Release date:2011-11-09
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope.
J.Mol.Biol., 415, 2012
3TYG
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CRYSTAL STRUCTURE OF BROAD AND POTENT HIV-1 NEUTRALIZING ANTIBODY PGT128 IN COMPLEX WITH A GLYCOSYLATED ENGINEERED GP120 OUTER DOMAIN WITH MINIV3 (EODMV3)
Descriptor:Envelope glycoprotein gp160, PGT128 light chain, Ig lambda-2 chain C regions, ...
Authors:Pejchal, R., Huang, P.S., Schief, W.R., Stanfield, R.L., Wilson, I.A.
Deposit date:2011-09-25
Release date:2011-10-19
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield.
Science, 334, 2011
4JPI
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CRYSTAL STRUCTURE OF A PUTATIVE VRC01 GERMLINE PRECURSOR FAB
Descriptor:Putative VRC01 germline Fab heavy chain, Putative VRC01 germline Fab light chain, GLYCEROL
Authors:Julien, J.-P., Diwanji, D.C., Jardine, J., Schief, W.R., Wilson, I.A.
Deposit date:2013-03-19
Release date:2013-04-10
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Rational HIV immunogen design to target specific germline B cell receptors.
Science, 340, 2013
4JPJ
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CRYSTAL STRUCTURE OF THE GERMLINE-TARGETING HIV-1 GP120 ENGINEERED OUTER DOMAIN, EOD-GT6
Descriptor:Germline-targeting HIV-1 gp120 engineered outer domain, eOD-GT6, N-ACETYL-D-GLUCOSAMINE
Authors:Julien, J.-P., Jardine, J., Schief, W.R., Wilson, I.A.
Deposit date:2013-03-19
Release date:2013-04-10
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Rational HIV immunogen design to target specific germline B cell receptors.
Science, 340, 2013
4JPK
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CRYSTAL STRUCTURE OF THE GERMLINE-TARGETING HIV-1 GP120 ENGINEERED OUTER DOMAIN EOD-GT6 IN COMPLEX WITH A PUTATIVE VRC01 GERMLINE PRECURSOR FAB
Descriptor:Putative VRC01 germline precursor Fab heavy chain, Putative VRC01 germline precursor Fab light chain, Germline-targeting HIV-1 gp120 engineered outer domain, ...
Authors:Julien, J.-P., Jardine, J., Schief, W.R., Wilson, I.A.
Deposit date:2013-03-19
Release date:2013-04-10
Last modified:2014-01-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Rational HIV immunogen design to target specific germline B cell receptors.
Science, 340, 2013
4L8I
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CRYSTAL STRUCTURE OF RSV EPITOPE SCAFFOLD FFL_005
Descriptor:RSV epitope scaffold FFL_005
Authors:Jardine, J., Correnti, C., Holmes, M.A., Strong, R.K., Schief, W.R.
Deposit date:2013-06-17
Release date:2014-02-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Proof of principle for epitope-focused vaccine design.
Nature, 507, 2014
5IDL
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CRYSTAL STRUCTURE OF THE GERMLINE-TARGETING HIV-1 GP120 ENGINEERED OUTER DOMAIN, EOD-GT8
Descriptor:Germline-targeting HIV-1 gp120 engineered outer domain, eOD-GT8, N-ACETYL-D-GLUCOSAMINE
Authors:Julien, J.P., Ereno-Orbea, J., Jardine, J.G., Schief, W.R., Wilson, I.A.
Deposit date:2016-02-24
Release date:2016-10-05
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen.
Science, 351, 2016
5KZC
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CRYSTAL STRUCTURE OF AN HIV-1 GP120 ENGINEERED OUTER DOMAIN WITH A MAN9 GLYCAN AT POSITION N276, IN COMPLEX WITH BROADLY NEUTRALIZING ANTIBODY VRC01
Descriptor:VRC01 Fab heavy chain, Engineered outer domain of gp120, VRC01 Fab light chain, ...
Authors:Julien, J.-P., Jardine, J.G., Diwanji, D., Schief, W.R., Wilson, I.A.
Deposit date:2016-07-24
Release date:2016-08-10
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.
Plos Pathog., 12, 2016
4JLR
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CRYSTAL STRUCTURE OF A DESIGNED RESPIRATORY SYNCYTIAL VIRUS IMMUNOGEN IN COMPLEX WITH MOTAVIZUMAB
Descriptor:Motavizumab Fab heavy chain, Motavizumab Fab light chain, RSV_1Isea designed scaffold, ...
Authors:Rupert, P.B., Correia, B., Schief, W., Strong, R.K.
Deposit date:2013-03-12
Release date:2014-02-05
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Proof of principle for epitope-focused vaccine design.
Nature, 507, 2014
3JWO
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STRUCTURE OF HIV-1 GP120 WITH GP41-INTERACTIVE REGION: LAYERED ARCHITECTURE AND BASIS OF CONFORMATIONAL MOBILITY
Descriptor:HIV-1 GP120 ENVELOPE GLYCOPROTEIN, T-cell surface glycoprotein CD4, FAB 48D LIGHT CHAIN, ...
Authors:Pancera, M., Majeed, S., Huang, C.C., Kwon, Y.D., Zhou, T., Robinson, J.E., Sodroski, J., Wyatt, R., Kwong, P.D.
Deposit date:2009-09-18
Release date:2009-12-29
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.51 Å)
Cite:Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility.
Proc.Natl.Acad.Sci.USA, 107, 2010
3LEF
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CRYSTAL STRUCTURE OF HIV EPITOPE-SCAFFOLD 4E10_S0_1Z6NA_001
Descriptor:Uncharacterized protein 4E10_S0_1Z6NA_001 (T18), 1,2-ETHANEDIOL
Authors:Holmes, M.A.
Deposit date:2010-01-14
Release date:2010-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope.
Structure, 18, 2010
3LF6
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CRYSTAL STRUCTURE OF HIV EPITOPE-SCAFFOLD 4E10_1XIZA_S0_001_N
Descriptor:Putative phosphotransferase system, PHOSPHATE ION
Authors:Holmes, M.A.
Deposit date:2010-01-15
Release date:2010-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope.
Structure, 18, 2010
3LF9
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CRYSTAL STRUCTURE OF HIV EPITOPE-SCAFFOLD 4E10_D0_1IS1A_001_C
Descriptor:4E10_D0_1IS1A_001_C (T161)
Authors:Holmes, M.A.
Deposit date:2010-01-16
Release date:2010-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope.
Structure, 18, 2010
3LG7
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CRYSTAL STRUCTURE OF HIV EPITOPE-SCAFFOLD 4E10_S0_1EZ3A_002_C
Descriptor:4E10_S0_1EZ3A_002_C (T246), SULFATE ION
Authors:Holmes, M.A.
Deposit date:2010-01-19
Release date:2010-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope.
Structure, 18, 2010
3LH2
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CRYSTAL STRUCTURE OF HIV EPITOPE-SCAFFOLD 4E10_1VI7A_S0_002_N 4E10 FV COMPLEX
Descriptor:4E10_1VI7A_S0_002_N (T88), Fv 4E10 heavy chain, Fv 4E10 light chain
Authors:Holmes, M.A.
Deposit date:2010-01-21
Release date:2010-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope.
Structure, 18, 2010
3LHP
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CRYSTAL STRUCTURE OF HIV EPITOPE-SCAFFOLD 4E10_D0_1ISEA_004_N 4E10 FV COMPLEX
Descriptor:Fv 4E10 heavy chain, Fv 4E10 light chain, 4E10_D0_1ISEA_004_N (T93), ...
Authors:Holmes, M.A.
Deposit date:2010-01-22
Release date:2010-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope.
Structure, 18, 2010
3QWO
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CRYSTAL STRUCTURE OF A MOTAVIZUMAB EPITOPE-SCAFFOLD BOUND TO MOTAVIZUMAB FAB
Descriptor:motavizumab light chain, motavizumab heavy chain, motavizumab epitope scaffold, ...
Authors:McLellan, J.S., Kwong, P.D.
Deposit date:2011-02-28
Release date:2011-05-04
Last modified:2011-08-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Design and characterization of epitope-scaffold immunogens that present the motavizumab epitope from respiratory syncytial virus.
J.Mol.Biol., 409, 2011
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