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5B2K
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A CRUCIAL ROLE OF CYS218 IN THE STABILIZATION OF AN UNPRECEDENTED AUTO-INHIBITION FORM OF MAP2K7
Descriptor:Dual specificity mitogen-activated protein kinase kinase 7
Authors:Sogabe, Y., Hashimoto, T., Matsumoto, T., Kirii, Y., Sawa, M., Kinoshita, T.
Deposit date:2016-01-19
Release date:2016-04-06
Last modified:2016-05-04
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:A crucial role of Cys218 in configuring an unprecedented auto-inhibition form of MAP2K7
Biochem.Biophys.Res.Commun., 473, 2016
5B2L
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A CRUCIAL ROLE OF CYS218 IN THE STABILIZATION OF AN UNPRECEDENTED AUTO-INHIBITION FORM OF MAP2K7
Descriptor:Dual specificity mitogen-activated protein kinase kinase 7, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL
Authors:Sogabe, Y., Hashimoto, T., Matsumoto, T., Kirii, Y., Sawa, M., Kinoshita, T.
Deposit date:2016-01-19
Release date:2016-04-06
Last modified:2016-05-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A crucial role of Cys218 in configuring an unprecedented auto-inhibition form of MAP2K7
Biochem.Biophys.Res.Commun., 473, 2016
5B2M
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A CRUCIAL ROLE OF CYS218 IN THE STABILIZATION OF AN UNPRECEDENTED AUTO-INHIBITION FORM OF MAP2K7
Descriptor:Dual specificity mitogen-activated protein kinase kinase 7
Authors:Sogabe, Y., Hashimoto, T., Matsumoto, T., Kirii, Y., Sawa, M., Kinoshita, T.
Deposit date:2016-01-19
Release date:2016-04-06
Last modified:2016-05-04
Method:X-RAY DIFFRACTION (3.06 Å)
Cite:A crucial role of Cys218 in configuring an unprecedented auto-inhibition form of MAP2K7
Biochem.Biophys.Res.Commun., 473, 2016
5Y90
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MAP2K7 MUTANT -C218S
Descriptor:Dual specificity mitogen-activated protein kinase kinase 7, GLYCEROL
Authors:Kinoshita, T., Hashimoto, T., Sogabe, Y., Matsumoto, T., Sawa, M., Fukada, H.
Deposit date:2017-08-22
Release date:2017-10-11
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:High-resolution structure discloses the potential for allosteric regulation of mitogen-activated protein kinase kinase 7
Biochem. Biophys. Res. Commun., 493, 2017
5ZZ4
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CRYSTAL STRUCTURE OF BRUTON'S TYROSINE KINASE IN COMPLEX WITH INHIBITOR 2E
Descriptor:Tyrosine-protein kinase BTK, N-[3-(4-amino-6-{[4-(morpholine-4-carbonyl)phenyl]amino}-1,3,5-triazin-2-yl)-2-methylphenyl]-4-tert-butylbenzamide
Authors:Kawahata, W., Asami, T., Irie, T., Kiyoi, T., Taniguchi, H., Asamitsu, Y., Inoue, T., Miyake, T., Sawa, M.
Deposit date:2018-05-30
Release date:2018-09-26
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Design and Synthesis of Novel Amino-triazine Analogues as Selective Bruton's Tyrosine Kinase Inhibitors for Treatment of Rheumatoid Arthritis.
J. Med. Chem., 61, 2018
5AX9
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CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF HUMAN TRAF2 AND NCK-INTERACTING PROTEIN KINASE IN COMPLEX WITH COMPUND 9
Descriptor:TRAF2 and NCK-interacting protein kinase, 4-methoxy-3-[2-[(3-methoxy-4-morpholin-4-yl-phenyl)amino]pyridin-4-yl]benzenecarbonitrile, SULFATE ION
Authors:Ohbayashi, N., Kukimoto-Niino, M., Yamada, T., Shirouzu, M.
Deposit date:2015-07-21
Release date:2016-07-27
Last modified:2016-09-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:TNIK inhibition abrogates colorectal cancer stemness
Nat Commun, 7, 2016
5CWZ
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CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF HUMAN TRAF2 AND NCK-INTERACTING PROTEIN KINASE
Descriptor:TRAF2 and NCK-interacting protein kinase
Authors:Ohbayashi, N., Kukimoto-Niino, M., Yamada, T., Shirouzu, M.
Deposit date:2015-07-28
Release date:2016-07-27
Last modified:2016-09-07
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:TNIK inhibition abrogates colorectal cancer stemness
Nat Commun, 7, 2016
5D7A
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CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF TRAF2 AND NCK-INTERACTING PROTEIN KINASE WITH NCB-0846
Descriptor:TRAF2 and NCK-interacting protein kinase, cis-4-{[2-(1H-benzimidazol-5-ylamino)quinazolin-8-yl]oxy}cyclohexanol, SULFATE ION
Authors:Ohbayashi, N., Kukimoto-Niino, M., Yamada, T., Shirouzu, M.
Deposit date:2015-08-13
Release date:2016-08-17
Last modified:2016-09-28
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:TNIK inhibition abrogates colorectal cancer stemness
Nat Commun, 7, 2016
3WZU
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THE STRUCTURE OF MAP2K7 IN COMPLEX WITH 5Z-7-OXOZEAENOL
Descriptor:Dual specificity mitogen-activated protein kinase kinase 7, (3S,5Z,8S,9S,11E)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione
Authors:Sogabe, Y., Hashimoto, Y., Matsumoto, T., Kinoshita, T.
Deposit date:2014-10-07
Release date:2015-01-14
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:5Z-7-Oxozeaenol covalently binds to MAP2K7 at Cys218 in an unprecedented manner
Bioorg.Med.Chem.Lett., 2014
5Y8U
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CRYSTAL STRUCTURE OF THE C276S MUTANT OF MAP2K7
Descriptor:Dual specificity mitogen-activated protein kinase kinase 7
Authors:Kinoshita, T.
Deposit date:2017-08-21
Release date:2017-10-11
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.92 Å)
Cite:High-resolution structure discloses the potential for allosteric regulation of mitogen-activated protein kinase kinase 7
Biochem. Biophys. Res. Commun., 493, 2017