6IQN
Crystal structure of TrkA kinase with ligand
Summary for 6IQN
| Entry DOI | 10.2210/pdb6iqn/pdb |
| Descriptor | High affinity nerve growth factor receptor, 4-[[4-azanyl-3-(4-cyclohexylpiperazin-1-yl)-9,10-bis(oxidanylidene)anthracen-1-yl]amino]benzoic acid (3 entities in total) |
| Functional Keywords | inhibitor, transferase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 68284.88 |
| Authors | Noritaka, F. (deposition date: 2018-11-08, release date: 2020-01-22, Last modification date: 2023-11-22) |
| Primary citation | Furuya, N.,Momose, T.,Katsuno, K.,Fushimi, N.,Muranaka, H.,Handa, C.,Sawa, M.,Ozawa, T.,Kinoshita, T. An isoform-selective inhibitor of tropomyosin receptor kinase A behaves as molecular glue. Bioorg.Med.Chem.Lett., 30:126775-126775, 2020 Cited by PubMed: 31699609DOI: 10.1016/j.bmcl.2019.126775 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.54 Å) |
Structure validation
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