6JWA
Crystal structure of CK2a1 with 5-iodotubercidin
Summary for 6JWA
| Entry DOI | 10.2210/pdb6jwa/pdb |
| Descriptor | Casein kinase II subunit alpha, (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, 1,2-ETHANEDIOL, ... (4 entities in total) |
| Functional Keywords | protein kinase, transferase, inhibitor, complex |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 41242.75 |
| Authors | Tsuyuguchi, M.,Kinoshita, T. (deposition date: 2019-04-19, release date: 2019-07-24, Last modification date: 2023-11-22) |
| Primary citation | Tsuyuguchi, M.,Nakaniwa, T.,Sawa, M.,Nakanishi, I.,Kinoshita, T. A promiscuous kinase inhibitor delineates the conspicuous structural features of protein kinase CK2a1. Acta Crystallogr.,Sect.F, 75:515-519, 2019 Cited by PubMed Abstract: Protein kinase CK2a1 is a serine/threonine kinase that plays a crucial role in the growth, proliferation and survival of cells and is a well known target for tumour and glomerulonephritis therapies. Here, the crystal structure of the kinase domain of CK2a1 complexed with 5-iodotubercidin (5IOD), an ATP-mimetic inhibitor, was determined at 1.78 Å resolution. The structure shows distinct structural features and, in combination with a comparison of the crystal structures of five off-target kinases complexed with 5IOD, provides valuable information for the development of highly selective inhibitors. PubMed: 31282872DOI: 10.1107/S2053230X19008951 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.781 Å) |
Structure validation
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