3WZU

THE STRUCTURE OF MAP2K7 IN COMPLEX WITH 5Z-7-oxozeaenol

Summary for 3WZU

DescriptorDual specificity mitogen-activated protein kinase kinase 7, (3S,5Z,8S,9S,11E)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione (3 entities in total)
Functional Keywordsprotein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus O14733
Total number of polymer chains1
Total molecular weight37361.28
Authors
Sogabe, Y.,Hashimoto, Y.,Matsumoto, T.,Kinoshita, T. (deposition date: 2014-10-07, release date: 2015-01-14, Last modification date: 2017-11-22)
Primary citation
Sogabe, Y.,Matsumoto, T.,Hashimoto, T.,Kirii, Y.,Sawa, M.,Kinoshita, T.
5Z-7-Oxozeaenol covalently binds to MAP2K7 at Cys218 in an unprecedented manner
Bioorg.Med.Chem.Lett., 2014
PubMed: 25529738 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmcl.2014.12.011
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.01 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.322385.0%20.1%6.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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