3WZU
THE STRUCTURE OF MAP2K7 IN COMPLEX WITH 5Z-7-oxozeaenol
Summary for 3WZU
| Entry DOI | 10.2210/pdb3wzu/pdb |
| Descriptor | Dual specificity mitogen-activated protein kinase kinase 7, (3S,5Z,8S,9S,11E)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione (3 entities in total) |
| Functional Keywords | protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Nucleus: O14733 |
| Total number of polymer chains | 1 |
| Total formula weight | 37361.28 |
| Authors | Sogabe, Y.,Hashimoto, Y.,Matsumoto, T.,Kinoshita, T. (deposition date: 2014-10-07, release date: 2015-01-14, Last modification date: 2023-11-08) |
| Primary citation | Sogabe, Y.,Matsumoto, T.,Hashimoto, T.,Kirii, Y.,Sawa, M.,Kinoshita, T. 5Z-7-Oxozeaenol covalently binds to MAP2K7 at Cys218 in an unprecedented manner. Bioorg.Med.Chem.Lett., 25:593-596, 2015 Cited by PubMed: 25529738DOI: 10.1016/j.bmcl.2014.12.011 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.01 Å) |
Structure validation
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