7X4H

Crystal structure of CK2a1 complexed with AG1112

Summary for 7X4H

Entry DOI	10.2210/pdb7x4h/pdb
Descriptor	Casein Kinase 2 subunit alpha, 5-azanyl-3-[(~{Z})-1-cyano-2-(1~{H}-indol-3-yl)ethenyl]-1~{H}-pyrazole-4-carbonitrile (3 entities in total)
Functional Keywords	protein kinase, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	41026.75
Authors	Ikeda, A.,Kinoshita, T.,Tsuyuguchi, M. (deposition date: 2022-03-02, release date: 2023-01-18, Last modification date: 2023-11-29)
Primary citation	Ikeda, A.,Tsuyuguchi, M.,Kitagawa, D.,Sawa, M.,Nakamura, S.,Nakanishi, I.,Kinoshita, T. Bivalent binding mode of an amino-pyrazole inhibitor indicates the potentials for CK2 alpha 1-selective inhibitors. Biochem.Biophys.Res.Commun., 630:30-35, 2022 Cited by PubMed: 36130444 DOI: 10.1016/j.bbrc.2022.09.040 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.77 Å)

Structure validation