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4FYM
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CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM OROTATE PHOSPHORIBOSYLTRANSFERASE
Descriptor:Orotate phosphoribosyltransferase, SULFATE ION
Authors:Rathod, P.K., Kumar, S.
Deposit date:2012-07-05
Release date:2013-08-07
Last modified:2015-06-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of Plasmodium falciparum orotate phosphoribosyltransferase with autologous inhibitory protein-protein interactions.
Acta Crystallogr F Struct Biol Commun, 71, 2015
6CA8
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CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM TOPOISOMERASE II DNA-BINDING, CLEAVAGE AND RE-LIGATION DOMAIN
Descriptor:DNA topoisomerase 2
Authors:Kumar, S., Kandavelu, P., Rathod, P.K.
Deposit date:2018-01-29
Release date:2019-02-06
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.331 Å)
Cite:Crystal structure of Plasmodium falciparum topoisomerase II DNA-binding, cleavage and re-ligation domain
To Be Published
2IEJ
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HUMAN PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH INHIBITOR COMPOUND STN-48 AND FPP ANALOG AT 1.8A RESOLUTION
Descriptor:Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit, Protein farnesyltransferase subunit beta, ACETATE ION, ...
Authors:Hast, M.A., Beese, L.S.
Deposit date:2006-09-19
Release date:2007-01-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase.
Mol.Biochem.Parasitol., 152, 2007
3BJE
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CRYSTAL STRUCTURE OF TRYPANOSOMA BRUCEI NUCLEOSIDE PHOSPHORYLASE SHOWS URIDINE PHOSPHORYLASE ACTIVITY
Descriptor:Nucleoside phosphorylase, putative, RIBOSE-1-PHOSPHATE, ...
Authors:Larson, E.T., Merritt, E.A., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2007-12-03
Release date:2007-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:The Crystal Structure and Activity of a Putative Trypanosomal Nucleoside Phosphorylase Reveal It to be a Homodimeric Uridine Phosphorylase
J.Mol.Biol., 396, 2010
3I65
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PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE BOUND WITH TRIAZOLOPYRIMIDINE-BASED INHIBITOR DSM1
Descriptor:Dihydroorotate dehydrogenase homolog, mitochondrial, 5-methyl-7-(naphthalen-2-ylamino)-1H-[1,2,4]triazolo[1,5-a]pyrimidine-3,8-diium, ...
Authors:Deng, X., Phillips, M.A.
Deposit date:2009-07-06
Release date:2009-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds.
J.Biol.Chem., 284, 2009
3I68
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PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE BOUND WITH TRIAZOLOPYRIMIDINE-BASED INHIBITOR DSM2
Descriptor:Dihydroorotate dehydrogenase homolog, mitochondrial, N-anthracen-2-yl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, ...
Authors:Deng, X., Phillips, M.A.
Deposit date:2009-07-06
Release date:2009-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds.
J.Biol.Chem., 284, 2009
3I6R
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PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE BOUND WITH TRIAZOLOPYRIMIDINE-BASED INHIBITOR DSM74
Descriptor:Dihydroorotate dehydrogenase homolog, mitochondrial, 5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine, ...
Authors:Deng, X., Phillips, M.A.
Deposit date:2009-07-07
Release date:2009-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds.
J.Biol.Chem., 284, 2009
3SFK
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CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE BOUND WITH INHIBITOR DSM267
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial, 2-(1,1-difluoroethyl)-5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine, ...
Authors:Deng, X., Phillips, M.
Deposit date:2011-06-13
Release date:2011-07-06
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential.
J.Med.Chem., 54, 2011
4OQV
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HIGH RESOLUTION CRYSTAL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE BOUND WITH DSM338 (N-[3,5-DIFLUORO-4-(TRIFLUOROMETHYL)PHENYL]-5-METHYL-2-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE)
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ...
Authors:Deng, X., Phillips, M.A.
Deposit date:2014-02-10
Release date:2014-06-04
Last modified:2014-07-09
Method:X-RAY DIFFRACTION (1.23 Å)
Cite:Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors.
J.Med.Chem., 57, 2014
4ORI
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RAT DIHYDROOROTATE DEHYDROGENASE BOUND WITH DSM338 (N-[3,5-DIFLUORO-4-(TRIFLUOROMETHYL)PHENYL]-5-METHYL-2-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE)
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ...
Authors:Deng, X., Phillips, M.A.
Deposit date:2014-02-11
Release date:2014-06-04
Last modified:2014-07-09
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors.
J.Med.Chem., 57, 2014
4ORM
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CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE BOUND WITH INHIBITOR DSM338 (N-[3,5-DIFLUORO-4-(TRIFLUOROMETHYL)PHENYL]-5-METHYL-2-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE)
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial, N-[3,5-difluoro-4-(trifluoromethyl)phenyl]-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, ...
Authors:Deng, X., Phillips, M.A.
Deposit date:2014-02-11
Release date:2014-06-04
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors.
J.Med.Chem., 57, 2014
4RX0
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CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE BOUND WITH INHIBITOR DSM265
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial, 2-(1,1-difluoroethyl)-5-methyl-N-[4-(pentafluoro-lambda~6~-sulfanyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine, ...
Authors:Deng, X., Phillips, M., Tomchick, D.
Deposit date:2014-12-08
Release date:2015-07-29
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria.
Sci Transl Med, 7, 2015
5BOO
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CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE BOUND WITH INHIBITOR DSM265
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial, 2-(1,1-difluoroethyl)-5-methyl-N-[4-(pentafluoro-lambda~6~-sulfanyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine, ...
Authors:Phillips, M., Deng, X., Tomchick, D.
Deposit date:2015-05-27
Release date:2015-07-29
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria.
Sci Transl Med, 7, 2015
5DEL
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CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE BOUND WITH INHIBITOR DSM59
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ...
Authors:Phillips, M., Deng, X.
Deposit date:2015-08-25
Release date:2015-10-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The X-ray structure of Plasmodium falciparum dihydroorotate dehydrogenase bound to a potent and selective N-phenylbenzamide inhibitor reveals novel binding-site interactions.
Acta Crystallogr.,Sect.F, 71, 2015
5FI8
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CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE BOUNDED WITH DSM422 (TETRAHYDRO-2-NAPHTHYL AND 2-INDANYL TRIAZOLOPYRIMIDINE)
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial, 2-[1,1-bis(fluoranyl)ethyl]-~{N}-[(2~{S})-7-bromanyl-1,2,3,4-tetrahydronaphthalen-2-yl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, ...
Authors:Deng, X., Kokkonda, S., Tomchick, D., Phillips, M.
Deposit date:2015-12-22
Release date:2016-05-18
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity.
J.Med.Chem., 59, 2016
5TBO
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CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE BOUND WITH INHIBITOR DSM421
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial, 2-(1,1-difluoroethyl)-5-methyl-N-[6-(trifluoromethyl)pyridin-3-yl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine, ...
Authors:Deng, X., Phillips, M.
Deposit date:2016-09-12
Release date:2016-09-28
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.151 Å)
Cite:A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria.
ACS Infect Dis, 2, 2016
6E0B
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PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE C276F MUTANT BOUND WITH TRIAZOLOPYRIMIDINE-BASED INHIBITOR DSM1
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial, 5-methyl-7-(naphthalen-2-ylamino)-1H-[1,2,4]triazolo[1,5-a]pyrimidine-3,8-diium, ...
Authors:Tomchick, D.R., Phillips, M.A., Deng, X.
Deposit date:2018-07-06
Release date:2018-11-14
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Identification and mechanistic understanding of dihydroorotate dehydrogenase point mutations in Plasmodium falciparum that confer in vitro resistance to the clinical candidate DSM265.
ACS Infect Dis, 2018
6GJG
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PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE DHODH IN COMPLEX WITH 3,6-DIMETHYL-N-(4-(TRIFLUOROMETHYL)PHENYL)-(1,2)OXAZOLO(5,4-D)PYRIMIDIN-4-AMINE
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ...
Authors:Rowland, P.
Deposit date:2018-05-16
Release date:2018-09-19
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Isoxazolopyrimidine-Based Inhibitors ofPlasmodium falciparumDihydroorotate Dehydrogenase with Antimalarial Activity.
ACS Omega, 3, 2018