4ORM
Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM338 (N-[3,5-difluoro-4-(trifluoromethyl)phenyl]-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine)
Summary for 4ORM
Entry DOI | 10.2210/pdb4orm/pdb |
Related | 4OQV 4ORI |
Descriptor | Dihydroorotate dehydrogenase (quinone), mitochondrial, N-[3,5-difluoro-4-(trifluoromethyl)phenyl]-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, FLAVIN MONONUCLEOTIDE, ... (7 entities in total) |
Functional Keywords | alpha/beta barrel, oxidoreductase, fmn, mitochondrial membrane, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Plasmodium falciparum More |
Cellular location | Mitochondrion inner membrane ; Single-pass membrane protein : Q08210 |
Total number of polymer chains | 1 |
Total formula weight | 46679.80 |
Authors | Deng, X.,Phillips, M.A. (deposition date: 2014-02-11, release date: 2014-06-04, Last modification date: 2024-02-28) |
Primary citation | Deng, X.,Kokkonda, S.,El Mazouni, F.,White, J.,Burrows, J.N.,Kaminsky, W.,Charman, S.A.,Matthews, D.,Rathod, P.K.,Phillips, M.A. Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors. J.Med.Chem., 57:5381-5394, 2014 Cited by PubMed: 24801997DOI: 10.1021/jm500481t PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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