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8K0B
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BU of 8k0b by Molmil
Cryo-EM structure of TMEM63C
Descriptor: Calcium permeable stress-gated cation channel 1
Authors:Qin, Y, Yu, D, Dong, J, Dang, S.
Deposit date:2023-07-08
Release date:2023-12-06
Method:ELECTRON MICROSCOPY (3.56 Å)
Cite:Cryo-EM structure of TMEM63C suggests it functions as a monomer.
Nat Commun, 14, 2023
4PXQ
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BU of 4pxq by Molmil
Crystal structure of D-glucuronyl C5-epimerase in complex with heparin hexasaccharide
Descriptor: 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, D-glucuronyl C5 epimerase B
Authors:Ke, J, Qin, Y, Gu, X, Tan, J, Brunzelle, J.S, Xu, H.E, Ding, K.
Deposit date:2014-03-24
Release date:2015-01-14
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and Functional Study of d-Glucuronyl C5-epimerase.
J.Biol.Chem., 290, 2015
4PW2
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BU of 4pw2 by Molmil
Crystal structure of D-glucuronyl C5 epimerase
Descriptor: CITRIC ACID, D-glucuronyl C5 epimerase B
Authors:Ke, J, Qin, Y, Gu, X, Brunzelle, J.S, Xu, H.E, Ding, K.
Deposit date:2014-03-18
Release date:2015-01-14
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Functional Study of d-Glucuronyl C5-epimerase.
J.Biol.Chem., 290, 2015
8J8Q
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BU of 8j8q by Molmil
Structure of the four-component Paf1 complex from Saccharomyces eubayanus
Descriptor: CDC73-like protein, CTR9-like protein, PAF1-like protein, ...
Authors:Wang, Z, Qin, Y, Zhou, Y, Cao, Y.
Deposit date:2023-05-02
Release date:2023-05-24
Last modified:2023-06-14
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:Structural Basis of the Transcriptional Elongation Factor Paf1 Core Complex from Saccharomyces eubayanus .
Int J Mol Sci, 24, 2023
8J8P
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BU of 8j8p by Molmil
Structure of the four-component Paf1 complex from Saccharomyces eubayanus
Descriptor: CDC73-like protein, CTR9-like protein, PAF1-like protein, ...
Authors:Wang, Z, Qin, Y, Zhou, Y, Cao, Y.
Deposit date:2023-05-02
Release date:2023-05-24
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Basis of the Transcriptional Elongation Factor Paf1 Core Complex from Saccharomyces eubayanus .
Int J Mol Sci, 24, 2023
4M1K
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BU of 4m1k by Molmil
Crystal structure of elongation factor G (EFG)
Descriptor: Elongation factor G, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Liu, G, Dong, J, Gong, W, Qin, Y.
Deposit date:2013-08-02
Release date:2014-08-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.952 Å)
Cite:Crystal structure of elongation factor G (EFG)
To be published
5ADY
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BU of 5ady by Molmil
Cryo-EM structures of the 50S ribosome subunit bound with HflX
Descriptor: 23S RRNA, 50S RIBOSOMAL PROTEIN L1, 50S RIBOSOMAL PROTEIN L10, ...
Authors:Zhang, Y, Mandava, C.S, Cao, W, Li, X, Zhang, D, Li, N, Zhang, Y, Zhang, X, Qin, Y, Mi, K, Lei, J, Sanyal, S, Gao, N.
Deposit date:2015-08-25
Release date:2015-10-14
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Hflx is a Ribosome Splitting Factor Rescuing Stalled Ribosomes Under Stress Conditions
Nat.Struct.Mol.Biol., 22, 2015
3JCE
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BU of 3jce by Molmil
Structure of Escherichia coli EF4 in pretranslocational ribosomes (Pre EF4)
Descriptor: 16S ribosomal RNA, 23 ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Zhang, D, Yan, K, Liu, G, Song, G, Luo, J, Shi, Y, Cheng, E, Wu, S, Jiang, T, Low, J, Gao, N, Qin, Y.
Deposit date:2015-12-01
Release date:2016-01-13
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome
Nat. Struct. Mol. Biol., 23, 2016
3JCD
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BU of 3jcd by Molmil
Structure of Escherichia coli EF4 in posttranslocational ribosomes (Post EF4)
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Zhang, D, Yan, K, Liu, G, Song, G, Luo, J, Shi, Y, Cheng, E, Wu, S, Jiang, T, Low, J, Gao, N, Qin, Y.
Deposit date:2015-12-01
Release date:2016-01-13
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome
Nat. Struct. Mol. Biol., 23, 2016
3DEG
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BU of 3deg by Molmil
Complex of elongating Escherichia coli 70S ribosome and EF4(LepA)-GMPPNP
Descriptor: 30S RNA helix 14, 30S RNA helix 8, 30S ribosomal protein S12, ...
Authors:Connell, S.R, Topf, M, Qin, Y, Wilson, D.N, Mielke, T, Fucini, P, Nierhaus, K.H, Spahn, C.M.T.
Deposit date:2008-06-10
Release date:2008-08-19
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (10.9 Å)
Cite:A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation
Nat.Struct.Mol.Biol., 15, 2008
4TZ7
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BU of 4tz7 by Molmil
Crystal structure of type I phosphatidylinositol 4-phosphate 5-kinase alpha from Zebrafish
Descriptor: Phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
Authors:Hu, J, Qin, Y, Wang, J, Li, L, Wu, D, Ha, Y.
Deposit date:2014-07-09
Release date:2015-09-02
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.31 Å)
Cite:Resolution of structure of PIP5K1A reveals molecular mechanism for its regulation by dimerization and dishevelled.
Nat Commun, 6, 2015
7EXA
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BU of 7exa by Molmil
Structure of mumps virus nucleoprotein without C-arm
Descriptor: Nucleoprotein, RNA (5'-R(P*UP*UP*UP*UP*UP*U)-3')
Authors:Shen, Q, Shan, H, Zhang, N, Qin, Y.
Deposit date:2021-05-26
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural plasticity of mumps virus nucleocapsids with cryo-EM structures.
Commun Biol, 4, 2021
4MYU
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BU of 4myu by Molmil
Crystal structure of elongation factor G mutant(EFG)
Descriptor: Elongation factor G, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Liu, G, Dong, J, Gong, W, Qin, Y.
Deposit date:2013-09-28
Release date:2014-08-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.004 Å)
Cite:Crystal structure of elongation factor G mutant(EFG)
To be published
4MYT
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BU of 4myt by Molmil
Crystal structure of elongation factor G (EFG)
Descriptor: Elongation factor G, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Liu, G, Dong, J, Gong, W, Qin, Y.
Deposit date:2013-09-28
Release date:2014-08-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.505 Å)
Cite:Crystal structure of elongation factor G (EFG)
To be published
7CPU
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BU of 7cpu by Molmil
Cryo-EM structure of 80S ribosome from mouse kidney
Descriptor: 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S13, ...
Authors:Huo, Y.G, He, X, Jiang, T, Qin, Y, Guo, X.J, Sha, J.H.
Deposit date:2020-08-08
Release date:2022-02-02
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.82 Å)
Cite:A male germ-cell-specific ribosome controls male fertility.
Nature, 612, 2022
7CPV
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BU of 7cpv by Molmil
Cryo-EM structure of 80S ribosome from mouse testis
Descriptor: 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S13, ...
Authors:Huo, Y.G, He, X, Jiang, T, Qin, Y, Guo, X.J, Sha, J.H.
Deposit date:2020-08-08
Release date:2022-02-02
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:A male germ-cell-specific ribosome controls male fertility.
Nature, 612, 2022
8JJ6
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BU of 8jj6 by Molmil
Structure of the NELF-BCE complex
Descriptor: NELF-E, Negative elongation factor B, Negative elongation factor complex member C/D
Authors:Wang, Z, Cao, Y, Qin, Y.
Deposit date:2023-05-29
Release date:2023-08-30
Last modified:2024-09-11
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Structural basis of the human negative elongation factor NELF-B/C/E ternary complex.
Biochem.Biophys.Res.Commun., 677, 2023
8I2N
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BU of 8i2n by Molmil
The RIPK1 kinase domain in complex with QY7-2B compound
Descriptor: Receptor-interacting serine/threonine-protein kinase 1, ~{N}-methyl-1-[4-[[[1-methyl-5-(phenylmethyl)pyrazol-3-yl]carbonylamino]methyl]phenyl]benzimidazole-5-carboxamide
Authors:Gong, X.Y, Li, Y, Meng, H.Y, Pan, L.F.
Deposit date:2023-01-14
Release date:2024-01-31
Last modified:2024-08-21
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Structure-based development of potent and selective type-II kinase inhibitors of RIPK1.
Acta Pharm Sin B, 14, 2024
7SHN
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BU of 7shn by Molmil
Cryo-EM structure of oleoyl-CoA-bound human peroxisomal fatty acid transporter ABCD1
Descriptor: ATP-binding cassette sub-family D member 1, S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name)
Authors:Wang, R, Li, X.
Deposit date:2021-10-09
Release date:2021-11-03
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis of acyl-CoA transport across the peroxisomal membrane by human ABCD1.
Cell Res., 32, 2022
7SHM
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BU of 7shm by Molmil
Cryo-EM structure of ATP-bound human peroxisomal fatty acid transporter ABCD1
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family D member 1
Authors:Wang, R, Li, X.
Deposit date:2021-10-09
Release date:2021-11-03
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.14 Å)
Cite:Structural basis of acyl-CoA transport across the peroxisomal membrane by human ABCD1.
Cell Res., 32, 2022
5FVZ
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BU of 5fvz by Molmil
Structure of bovine endothelial nitric oxide synthase heme domain in complex with 6-(2-(5-(3-(dimethylamino)propyl)pyridin-3-yl)ethyl)-4-methylpyridin-2-amine
Descriptor: 5,6,7,8-TETRAHYDROBIOPTERIN, 6-(2-(5-(3-(DIMETHYLAMINO)PROPYL)PYRIDIN-3-YL)ETHYL)-4-METHYLPYRIDIN-2-AMINE, CHLORIDE ION, ...
Authors:Li, H, Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2.048 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
5FVQ
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BU of 5fvq by Molmil
Structure of rat neuronal nitric oxide synthase heme domain in complex with 4-methyl-6-(2-(5-(4-methylpiperazin-1-yl)pyridin-3-yl) ethyl)pyridin-2-amine
Descriptor: 4-methyl-6-(2-(5-(4-methylpiperazin-1-yl)pyridin-3-yl)ethyl)pyridin-2-amine, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ...
Authors:Li, H, Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
5FVS
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BU of 5fvs by Molmil
Structure of rat neuronal nitric oxide synthase heme domain in complex with 4-methyl-6-(2-(5-(3-(methylamino)propyl)pyridin-3-yl) ethyl)pyridin-2-amine
Descriptor: 4-METHYL-6-(2-(5-(3-(METHYLAMINO)PROPYL)PYRIDIN-3-YL)ETHYL)PYRIDIN-2-AMINE, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ...
Authors:Li, H, Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.948 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
5FVY
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BU of 5fvy by Molmil
Structure of bovine endothelial nitric oxide synthase heme domain in complex with 4-methyl-6-(2-(5-(4-methylpiperazin-1-yl)pyridin-3-yl) ethyl)pyridin-2-amine
Descriptor: 1,2-ETHANEDIOL, 4-methyl-6-(2-(5-(4-methylpiperazin-1-yl)pyridin-3-yl)ethyl)pyridin-2-amine, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Li, H, Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2.098 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
7OF9
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BU of 7of9 by Molmil
Keap1 kelch domain bound to a small molecule fragment
Descriptor: DIMETHYL SULFOXIDE, Kelch-like ECH-associated protein 1, [(4S)-6,7-dihydro-4H-thieno[3,2-c]pyran-4-yl]methanamine
Authors:Narayanan, D, Bach, A, Gajhede, M.
Deposit date:2021-05-04
Release date:2022-11-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery.
J.Med.Chem., 65, 2022

 

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