5FVZ

Structure of bovine endothelial nitric oxide synthase heme domain in complex with 6-(2-(5-(3-(dimethylamino)propyl)pyridin-3-yl)ethyl)-4-methylpyridin-2-amine

Summary for 5FVZ

Related5FVO 5FVP 5FVQ 5FVR 5FVS 5FVT 5FVU 5FVV 5FVW 5FVX 5FVY 5FW0
DescriptorENDOTHELIAL NITRIC OXIDE SYNTHASE, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (8 entities in total)
Functional Keywordsoxidoreductase, nitric oxide synthase, inhibitor complex
Biological sourceBOS TAURUS (BOVINE)
Cellular locationCell membrane  P29473
Total number of polymer chains2
Total molecular weight102086.85
Authors
Li, H.,Poulos, T.L. (deposition date: 2016-02-10, release date: 2016-04-20, Last modification date: 2016-06-08)
Primary citation
Wang, H.,Qin, Y.,Li, H.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B.
Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59:4913-, 2016
PubMed: 27050842 (PDB entries with the same primary citation)
DOI: 10.1021/ACS.JMEDCHEM.6B00273
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.048 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.210203.9%4.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report