5FW0
Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(2-(5-((2-methoxyethyl)(methyl)amino)pyridin-3-yl) ethyl)-4-methylpyridin-2-amine
Summary for 5FW0
Entry DOI | 10.2210/pdb5fw0/pdb |
Related | 5FVO 5FVP 5FVQ 5FVR 5FVS 5FVT 5FVU 5FVV 5FVW 5FVX 5FVY 5FVZ |
Descriptor | NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total) |
Functional Keywords | oxidoreductase, nitric oxide synthase, inhibitor complex |
Biological source | RATTUS NORVEGICUS (NORWAY RAT) |
Cellular location | Cell membrane, sarcolemma ; Peripheral membrane protein : P29476 |
Total number of polymer chains | 2 |
Total formula weight | 100124.82 |
Authors | Li, H.,Poulos, T.L. (deposition date: 2016-02-10, release date: 2016-04-20, Last modification date: 2024-05-08) |
Primary citation | Wang, H.,Qin, Y.,Li, H.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B. Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker. J.Med.Chem., 59:4913-, 2016 Cited by PubMed: 27050842DOI: 10.1021/ACS.JMEDCHEM.6B00273 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report