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6E05
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DETHIOBIOTIN SYNTHETASE IN COMPLEX WITH CYTIDINE TRIPHOSPHATE SOLVED BY PRECIPITANT-LIGAND EXCHANGE (CRYSTALS GROWN IN SULFATE PRECIPITANT)
Descriptor:ATP-dependent dethiobiotin synthetase BioD, MAGNESIUM ION, CYTIDINE-5'-TRIPHOSPHATE
Authors:Thompson, A.P., Wegener, K.L., Bruning, J.B., Polyak, S.W.
Deposit date:2018-07-06
Release date:2018-10-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Precipitant-ligand exchange technique reveals the ADP binding mode in Mycobacterium tuberculosis dethiobiotin synthetase.
Acta Crystallogr D Struct Biol, 74, 2018
6E06
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DETHIOBIOTIN SYNTHETASE IN COMPLEX WITH CYTIDINE TRIPHOSPHATE SOLVED BY PRECIPITANT-LIGAND EXCHANGE (CRYSTALS GROWN IN CITRATE PRECIPITANT)
Descriptor:ATP-dependent dethiobiotin synthetase BioD, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Thompson, A.P., Wegener, K.L., Bruning, J.B., Polyak, S.W.
Deposit date:2018-07-06
Release date:2018-10-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Precipitant-ligand exchange technique reveals the ADP binding mode in Mycobacterium tuberculosis dethiobiotin synthetase.
Acta Crystallogr D Struct Biol, 74, 2018
6CZB
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DETHIOBIOTIN SYNTHETASE IN COMPLEX WITH URIDINE TRIPHOSPHATE (UTP) - PROMISCUOUS BINDING MODE WITH DISORDERED NUCLEOSIDE
Descriptor:ATP-dependent dethiobiotin synthetase BioD, MAGNESIUM ION, URIDINE 5'-TRIPHOSPHATE
Authors:Thompson, A.P., Wegener, K.L., Bruning, J.B., Polyak, S.W.
Deposit date:2018-04-09
Release date:2018-11-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes
Acs Catalysis, 8(11), 2018
6CZC
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DETHIOBIOTIN SYNTHETASE IN COMPLEX WITH THYMIDINE TRIPHOSPHATE (TTP) - PROMISCUOUS BINDING MODE WITH DISORDERED NUCLEOSIDE
Descriptor:ATP-dependent dethiobiotin synthetase BioD, MAGNESIUM ION, THYMIDINE-5'-TRIPHOSPHATE
Authors:Thompson, A.P., Wegener, K.L., Bruning, J.B., Polyak, S.W.
Deposit date:2018-04-09
Release date:2018-11-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes
Acs Catalysis, 8(11), 2018
6CZD
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DETHIOBIOTIN SYNTHETASE IN COMPLEX WITH ADENOSINE DIPHOSPHATE
Descriptor:ATP-dependent dethiobiotin synthetase BioD, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE
Authors:Thompson, A.P., Wegener, K.L., Bruning, J.B., Polyak, S.W.
Deposit date:2018-04-09
Release date:2018-10-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Precipitant-ligand exchange technique reveals the ADP binding mode in Mycobacterium tuberculosis dethiobiotin synthetase.
Acta Crystallogr D Struct Biol, 74, 2018
6CZE
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DETHIOBIOTIN SYNTHETASE IN COMPLEX WITH INOSINE TRIPHOSPHATE (ITP) - PROMISCUOUS BINDING MODE WITH DISORDERED NUCLEOSIDE
Descriptor:ATP-dependent dethiobiotin synthetase BioD, INOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Thompson, A.P., Wegener, K.L., Bruning, J.B., Polyak, S.W.
Deposit date:2018-04-09
Release date:2018-11-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes
Acs Catalysis, 8(11), 2018
6CVV
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DETHIOBIOTIN SYNTHETASE IN COMPLEX WITH ADENOSINE TRIPHOSPHATE (ATP) - PROMISCUOUS BINDING MODE WITH DISORDERED NUCLEOSIDE
Descriptor:ATP-dependent dethiobiotin synthetase BioD, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Thompson, A.P., Wegener, K.L., Bruning, J.B., Polyak, S.W.
Deposit date:2018-03-29
Release date:2018-11-21
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes
Acs Catalysis, 8(11), 2018
6CVE
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DETHIOBIOTIN SYNTHETASE IN COMPLEX WITH CYTIDINE TRIPHOSPHATE AND 7,8-DIAMINOPELARGONIC ACID
Descriptor:ATP-dependent dethiobiotin synthetase BioD, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Thompson, A.P., Bruning, J.B., Wegener, K.L., Polyak, S.W.
Deposit date:2018-03-28
Release date:2018-11-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes
Acs Catalysis, 8(11), 2018
6CVF
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DETHIOBIOTIN SYNTHETASE IN COMPLEX WITH CYTIDINE DIPHOSPHATE
Descriptor:ATP-dependent dethiobiotin synthetase BioD, CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Thompson, A.P., Bruning, J.B., Wegener, K.L., Polyak, S.W.
Deposit date:2018-03-28
Release date:2018-11-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes
Acs Catalysis, 8(11), 2018
6CVU
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DETHIOBIOTIN SYNTHETASE IN COMPLEX WITH CYTIDINE
Descriptor:ATP-dependent dethiobiotin synthetase BioD, SULFATE ION, 4-AMINO-1-BETA-D-RIBOFURANOSYL-2(1H)-PYRIMIDINONE
Authors:Thompson, A.P., Wegener, K.L., Bruning, J.B., Polyak, S.W.
Deposit date:2018-03-28
Release date:2018-11-21
Method:X-RAY DIFFRACTION (2.426 Å)
Cite:Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes
Acs Catalysis, 8(11), 2018
6F5M
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CRYSTAL STRUCTURE OF HIGHLY GLYCOSYLATED HUMAN LEUKOCYTE ELASTASE IN COMPLEX WITH A THIAZOLIDINEDIONE INHIBITOR
Descriptor:Neutrophil elastase, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Hochscherf, J., Pietsch, M., Tieu, W., Kuan, K., Hautmann, S., Abell, A., Guetschow, M., Niefind, K.
Deposit date:2017-12-01
Release date:2018-08-08
Last modified:2018-08-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of highly glycosylated human leukocyte elastase in complex with an S2' site binding inhibitor.
Acta Crystallogr F Struct Biol Commun, 74, 2018
6AQQ
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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS BIOTIN PROTEIN LIGASE IN COMPLEX WITH INHIBITOR
Descriptor:Bifunctional ligase/repressor BirA, (3aS,4S,6aR)-4-(5-{1-[(3-fluorophenyl)methyl]-1H-1,2,3-triazol-4-yl}pentyl)tetrahydro-1H-thieno[3,4-d]imidazol-2(3H)-one
Authors:Cini, D.A., Wilce, M.C.J.
Deposit date:2017-08-21
Release date:2018-02-07
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Halogenation of Biotin Protein Ligase Inhibitors Improves Whole Cell Activity against Staphylococcus aureus.
ACS Infect Dis, 4, 2018
6APW
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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS BIOTIN PROTEIN LIGASE IN COMPLEX WITH INHIBITOR
Descriptor:Bifunctional ligase/repressor BirA, 4-[(4-{5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentyl}-1H-1,2,3-triazol-1-yl)methyl]benzoic acid
Authors:Cini, D.A., Wilce, M.C.J.
Deposit date:2017-08-18
Release date:2018-02-07
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.614 Å)
Cite:Halogenation of Biotin Protein Ligase Inhibitors Improves Whole Cell Activity against Staphylococcus aureus.
ACS Infect Dis, 4, 2018
4WOP
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NUCLEOTIDE TRIPHOSPHATE PROMISCUITY IN MYCOBACTERIUM TUBERCULOSIS DETHIOBIOTIN SYNTHETASE
Descriptor:ATP-dependent dethiobiotin synthetase BioD, CYTIDINE-5'-TRIPHOSPHATE, SULFATE ION
Authors:Salaemae, W., Yap, M.Y., Wegener, K.L., Booker, G.W., Wilce, M.C.J., Polyak, S.W.
Deposit date:2014-10-16
Release date:2015-04-08
Last modified:2015-05-27
Method:X-RAY DIFFRACTION (2.393 Å)
Cite:Nucleotide triphosphate promiscuity in Mycobacterium tuberculosis dethiobiotin synthetase.
Tuberculosis (Edinb), 95, 2015
4R06
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CRYSTAL STRUCTURE OF SR2067 BOUND TO PPARGAMMA
Descriptor:Peroxisome proliferator-activated receptor gamma, 1-(naphthalen-1-ylsulfonyl)-N-[(1S)-1-phenylpropyl]-1H-indole-5-carboxamide, SULFATE ION
Authors:Marrewijk, L., Kamenecka, T., Griffin, P.R., Bruning, J.B.
Deposit date:2014-07-30
Release date:2016-01-27
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:SR2067 Reveals a Unique Kinetic and Structural Signature for PPAR gamma Partial Agonism.
Acs Chem.Biol., 11, 2016
4DQ2
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STRUCTURE OF STAPHYLOCOCCUS AUREUS BIOTIN PROTEIN LIGASE IN COMPLEX WITH BIOTINOL-5'-AMP
Descriptor:Biotin-[acetyl-CoA-carboxylase] ligase, ((2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDROFURAN-2-YL)METHYL 5-((3AS,4S,6AR)-2-OXO-HEXAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-4-YL)PENTYL HYDROGEN PHOSPHATE
Authors:Wilce, M., Yap, M., Pendini, N., Soares de Costa, T., Polyak, S., Tieu, W., Booker, G., Wallace, J.
Deposit date:2012-02-14
Release date:2012-04-18
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Selective inhibition of biotin protein ligase from Staphylococcus aureus.
J.Biol.Chem., 287, 2012
3V8J
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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS BIOTIN PROTEIN LIGASE
Descriptor:Biotin ligase
Authors:Pendini, N.R., Yap, M.Y.
Deposit date:2011-12-23
Release date:2012-12-26
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Selective inhibition of biotin protein ligase from Staphylococcus aureus.
J.Biol.Chem., 287, 2012
3V8K
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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS BIOTIN PROTEIN LIGASE IN COMPLEX WITH BIOTIN
Descriptor:Biotin ligase, BIOTIN
Authors:Yap, M.Y., Pendini, N.R.
Deposit date:2011-12-23
Release date:2012-12-26
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (3.23 Å)
Cite:Selective inhibition of biotin protein ligase from Staphylococcus aureus.
J.Biol.Chem., 287, 2012
3V8L
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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS BIOTIN PROTEIN LIGASE IN COMPLEX WITH BIOTINYL-5'-AMP
Descriptor:Biotin ligase, BIOTINYL-5-AMP
Authors:Yap, M.Y.
Deposit date:2011-12-23
Release date:2012-12-26
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Selective inhibition of biotin protein ligase from Staphylococcus aureus.
J.Biol.Chem., 287, 2012
3V7R
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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS BIOTIN PROTEIN LIGASE IN COMPLEX WITH INHIBITOR
Descriptor:Biotin ligase, (3aS,4S,6aR)-4-(5-{1-[4-(6-amino-9H-purin-9-yl)butyl]-1H-1,2,3-triazol-4-yl}pentyl)tetrahydro-1H-thieno[3,4-d]imidazol-2(3H)-one
Authors:Yap, M.Y., Pendini, N.R.
Deposit date:2011-12-21
Release date:2012-12-26
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Selective inhibition of biotin protein ligase from Staphylococcus aureus.
J.Biol.Chem., 287, 2012
3V7S
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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS BIOTIN PROTEIN LIGASE IN COMPLEX WITH INHIBITOR 0364
Descriptor:Biotin ligase, 5-methyl-3-[4-(4-{5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentyl}-1H-1,2,3-triazol-1-yl)butyl]-1,3-benzoxazol-2(3H)-one
Authors:Yap, M.Y., Pendini, N.R.
Deposit date:2011-12-21
Release date:2012-04-25
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Selective inhibition of biotin protein ligase from Staphylococcus aureus.
J.Biol.Chem., 287, 2012
3V7C
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CYSTAL STRUCTURE OF SABPL IN COMPLEX WITH INHIBITOR
Descriptor:Biotin ligase, 5'-deoxy-2',3'-O-(1-methylethylidene)-5'-(4-{5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentyl}-1H-1,2,3-triazol-1-yl)adenosine
Authors:Yap, M.Y., Pendini, N.R.
Deposit date:2011-12-20
Release date:2012-04-18
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Selective inhibition of biotin protein ligase from Staphylococcus aureus.
J.Biol.Chem., 287, 2012
3RKW
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STRUCTURAL CHARACTERISATION OF STAPHYLOCOCCUS AUREUS BIOTIN PROTEIN LIGASE
Descriptor:Biotin-[acetyl-CoA-carboxylase] ligase, BIOTINYL-5-AMP
Authors:Wilce, M.C.J., Pendini, N.R., Yap, M.Y.
Deposit date:2011-04-18
Release date:2012-04-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural characterisation of staphylococcus aureus biotin protein ligase
To be published
3RKX
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STRUCTURAL CHARACTERISATION OF STAPHYLOCOCCUS AUREUS BIOTIN PROTEIN LIGASE
Descriptor:Biotin-[acetyl-CoA-carboxylase] ligase
Authors:Wilce, M.C.J.
Deposit date:2011-04-18
Release date:2012-04-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural characterisation of staphylococcus aureus biotin protein ligase
TO BE PUBLISHED
3RKY
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STRUCTURAL CHARACTERISATION OF STAPHYLOCOCCUS AUREUS BIOTIN PROTEIN LIGASE
Descriptor:Biotin-[acetyl-CoA-carboxylase] ligase, BIOTIN
Authors:Wilce, M.C.J.
Deposit date:2011-04-18
Release date:2012-04-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.232 Å)
Cite:Structural characterisation of staphylococcus aureus biotin protein ligase
To be Published