Author results

2DCT
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CRYSTAL STRUCTURE OF THE TT1209 FROM THERMUS THERMOPHILUS HB8
Descriptor:hypothetical protein TTHA0104, SODIUM ION, CHLORIDE ION
Authors:Asada, Y., Sugahara, M., Shimizu, K., Yamamoto, H., Shimada, H., Nakamoto, T., Ono, N., Kunishima, N., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-01-12
Release date:2006-01-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal structure of the TT1209 from Thermus thermophilus HB8
To be Published
2EJZ
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STRUCTURAL STUDY OF PROJECT ID PH0725 FROM PYROCOCCUS HORIKOSHII OT3 (Y11M)
Descriptor:diphthine synthase, SODIUM ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Asada, Y., Taketa, M., Ono, N., Matsuura, Y., Kunishima, N., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-03-22
Release date:2007-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural study of Project ID PH0725 from Pyrococcus horikoshii OT3 (Y11M)
To be Published
2EKZ
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STRUCTURAL STUDY OF PROJECT ID TTHB049 FROM THERMUS THERMOPHILUS HB8 (L52M)
Descriptor:Alpha-ribazole-5'-phosphate phosphatase
Authors:Asada, Y., Matsuura, Y., Ono, N., Nakamoto, T., Kunishima, N., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-03-26
Release date:2007-10-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural study of Project ID TTHB049 from Thermus thermophilus HB8 (L52M)
To be Published
2EL0
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STRUCTURAL STUDY OF PROJECT ID PH0725 FROM PYROCOCCUS HORIKOSHII OT3 (L21M)
Descriptor:diphthine synthase, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Asada, Y., Matsuura, Y., Ono, N., Shimada, H., Kunishima, N., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-03-26
Release date:2007-10-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural study of Project ID PH0725 from Pyrococcus horikoshii OT3 (L21M)
To be Published
2EL1
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STRUCTURAL STUDY OF PROJECT ID PH0725 FROM PYROCOCCUS HORIKOSHII OT3 (L44M)
Descriptor:diphthine synthase, SODIUM ION, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Asada, Y., Taketa, M., Ono, N., Matsuura, Y., Kunishima, N., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-03-26
Release date:2007-10-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural study of Project ID PH0725 from Pyrococcus horikoshii OT3 (L44M)
To be Published
2EL3
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STRUCTURAL STUDY OF PROJECT ID PH0725 FROM PYROCOCCUS HORIKOSHII OT3 (L242M)
Descriptor:diphthine synthase, SODIUM ION, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Asada, Y., Matsuura, Y., Ono, N., Shimada, H., Kunishima, N., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-03-26
Release date:2007-10-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural study of Project ID PH0725 from Pyrococcus horikoshii OT3 (L242M)
To be Published
2EOA
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STRUCTURAL STUDY OF PROJECT ID TTHB049 FROM THERMUS THERMOPHILUS HB8 (W85H)
Descriptor:Alpha-ribazole-5'-phosphate phosphatase
Authors:Asada, Y., Taketa, M., Ono, N., Matsuura, Y., Kunishima, N., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-03-29
Release date:2007-10-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural study of Project ID TTHB049 from Thermus thermophilus HB8 (W85H)
To be Published
2OWD
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CRYSTAL STRUCTURE OF TTHB049 FROM THERMUS THERMOPHILUS HB8
Descriptor:Alpha-ribazole-5'-phosphate phosphatase, GLYCEROL, SODIUM ION
Authors:Sugahara, M., Taketa, M., Ono, N., Matsuura, Y., Kunishima, N., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-02-16
Release date:2007-08-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of TTHB049 from Thermus thermophilus HB8
To be Published
2OWK
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CRYSTAL STRUCTURE OF PH0725 FROM PYROCOCCUS HORIKOSHII OT3
Descriptor:diphthine synthase, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION
Authors:Sugahara, M., Matsuura, Y., Ono, N., Nakamoto, T., Kunishima, N., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-02-16
Release date:2007-08-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of PH0725 from Pyrococcus horikoshii OT3
To be Published
2P2X
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CRYSTAL STRUCTURE OF PH0725 FROM PYROCOCCUS HORIKOSHII OT3
Descriptor:Probable diphthine synthase, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Sugahara, M., Ono, N., Taketa, M., Matsuura, Y., Kunishima, N., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-03-08
Release date:2007-09-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of PH0725 from Pyrococcus horikoshii OT3
To be Published
2P5C
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CRYSTAL STRUCTURE OF PH0725 FROM PYROCOCCUS HORIKOSHII OT3
Descriptor:diphthine synthase, S-ADENOSYL-L-HOMOCYSTEINE, GLYCEROL
Authors:Yamamoto, H., Taketa, M., Ono, N., Matsuura, Y., Kunishima, N., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-03-15
Release date:2007-09-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of PH0725 from Pyrococcus horikoshii OT3
To be Published
2PCH
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CRYSTAL STRUCTURE OF PH0725 FROM PYROCOCCUS HORIKOSHII OT3
Descriptor:Probable diphthine synthase, SODIUM ION, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Sugahara, M., Taketa, M., Ono, N., Matsuura, Y., Kunishima, N., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-03-29
Release date:2007-10-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of PH0725 from Pyrococcus horikoshii OT3
To be Published
3B24
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HSP90 ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH AN AMINOTRIAZINE FRAGMENT MOLECULE
Descriptor:Heat shock protein HSP 90-alpha, MAGNESIUM ION, 4-(ethylsulfanyl)-6-methyl-1,3,5-triazin-2-amine
Authors:Fukami, T.A., Ono, N.
Deposit date:2011-07-21
Release date:2011-09-14
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design
Bioorg.Med.Chem.Lett., 21, 2011
3B25
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HSP90 ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH AN INHIBITOR CH4675194
Descriptor:Heat shock protein HSP 90-alpha, 4-Methyl-6-(toluene-4-sulfonyl)-pyrimidin-2-ylamine
Authors:Fukami, T.A., Ono, N.
Deposit date:2011-07-21
Release date:2011-09-14
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design
Bioorg.Med.Chem.Lett., 21, 2011
3B26
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HSP90 ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH AN INHIBITOR RO1127850
Descriptor:Heat shock protein HSP 90-alpha, 4-(1H,3H-benzo[de]isochromen-6-yl)-6-methylpyrimidin-2-amine
Authors:Fukami, T.A., Ono, N.
Deposit date:2011-07-21
Release date:2011-09-14
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design
Bioorg.Med.Chem.Lett., 21, 2011
3B27
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HSP90 ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH AN INHIBITOR RO4919127
Descriptor:Heat shock protein HSP 90-alpha, 4-(2-chlorophenyl)-6-(methylsulfanyl)-1,3,5-triazin-2-amine
Authors:Fukami, T.A., Ono, N.
Deposit date:2011-07-21
Release date:2011-09-14
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design
Bioorg.Med.Chem.Lett., 21, 2011
3B28
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HSP90 ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH AN INHIBITOR CH5015765
Descriptor:Heat shock protein HSP 90-alpha, GLYCEROL, 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(methylsulfanyl)-1,3,5-triazin-2-amine, ...
Authors:Fukami, T.A., Ono, N.
Deposit date:2011-07-21
Release date:2011-09-14
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design
Bioorg.Med.Chem.Lett., 21, 2011
3VHA
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HSP90 ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH A MACROCYCLIC INHIBITOR
Descriptor:Heat shock protein HSP 90-alpha, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 22-methyl-13,18-dioxa-7-thia-3,5-diazatetracyclo[17.3.1.1~2,6~.1~8,12~]pentacosa-1(23),2(25),3,5,8(24),9,11,19,21-nonaen-4-amine
Authors:Fukami, T.A., Ono, N.
Deposit date:2011-08-24
Release date:2012-07-18
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors
Bioorg.Med.Chem.Lett., 22, 2012
3VHC
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HSP90 ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH A MACROCYCLIC INHIBITOR
Descriptor:Heat shock protein HSP 90-alpha, 4-amino-20,22-dimethyl-13-oxa-7-thia-3,5,17-triazatetracyclo[17.3.1.1~2,6~.1~8,12~]pentacosa-1(23),2(25),3,5,8(24),9,11,19,21-nonaen-18-one, MAGNESIUM ION
Authors:Fukami, T.A., Ono, N.
Deposit date:2011-08-24
Release date:2012-07-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors
Bioorg.Med.Chem.Lett., 22, 2012
3VHD
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HSP90 ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH A MACROCYCLIC INHIBITOR, CH5164840
Descriptor:Heat shock protein HSP 90-alpha, 4-amino-18,20-dimethyl-7-thia-3,5,11,15-tetraazatricyclo[15.3.1.1(2,6)]docosa-1(20),2,4,6(22),17(21),18-hexaene-10,16-dione
Authors:Fukami, T.A., Ono, N.
Deposit date:2011-08-24
Release date:2012-07-18
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors
Bioorg.Med.Chem.Lett., 22, 2012
3WHA
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HSP90 ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH A TRICYCLIC INHIBITOR
Descriptor:Heat shock protein HSP 90-alpha, GLYCEROL, 4-{[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazin-2-yl]sulfanyl}butanamide, ...
Authors:Fukami, T.A., Ono, N.
Deposit date:2013-08-23
Release date:2014-01-29
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Design and synthesis of 2-amino-6-(1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazines as novel Hsp90 inhibitors
Bioorg.Med.Chem., 22, 2014
2P6K
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CRYSTAL STRUCTURE OF PH0725 FROM PYROCOCCUS HORIKOSHII OT3
Descriptor:diphthine synthase, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION
Authors:Yamamoto, H., Matsuura, Y., Ono, N., Nakamoto, T., Kunishima, N., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-03-18
Release date:2007-09-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of PH0725 from Pyrococcus horikoshii OT3
To be Published
2P6L
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CRYSTAL STRUCTURE OF PH0725 FROM PYROCOCCUS HORIKOSHII OT3
Descriptor:diphthine synthase, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Yamamoto, H., Matsuura, Y., Ono, N., Shimada, H., Kunishima, N., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-03-19
Release date:2007-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of PH0725 from Pyrococcus horikoshii OT3
To be Published
2PB5
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CRYSTAL STRUCTURE OF PH0725 FROM PYROCOCCUS HORIKOSHII OT3
Descriptor:diphthine synthase, S-ADENOSYL-L-HOMOCYSTEINE, FORMIC ACID, ...
Authors:Yamamoto, H., Taketa, M., Ono, N., Matsuura, Y., Kunishima, N., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-03-28
Release date:2007-10-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of PH0725 from Pyrococcus horikoshii OT3
To be Published
2PB6
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CRYSTAL STRUCTURE OF PH0725 FROM PYROCOCCUS HORIKOSHII OT3
Descriptor:Probable diphthine synthase, S-ADENOSYL-L-HOMOCYSTEINE, GLYCEROL, ...
Authors:Yamamoto, H., Taketa, M., Ono, N., Matsuura, Y., Kunishima, N., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-03-28
Release date:2007-10-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of PH0725 from Pyrococcus horikoshii OT3
To be Published
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