3VHA

Hsp90 alpha N-terminal domain in complex with a macrocyclic inhibitor

Summary for 3VHA

Entry DOI	10.2210/pdb3vha/pdb
Related	3B24 3B25 3B26 3B27 3B28 3VHC 3VHD
Descriptor	Heat shock protein HSP 90-alpha, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 22-methyl-13,18-dioxa-7-thia-3,5-diazatetracyclo[17.3.1.1~2,6~.1~8,12~]pentacosa-1(23),2(25),3,5,8(24),9,11,19,21-nonaen-4-amine, ... (4 entities in total)
Functional Keywords	chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P07900
Total number of polymer chains	1
Total formula weight	26362.68
Authors	Fukami, T.A.,Ono, N. (deposition date: 2011-08-24, release date: 2012-07-18, Last modification date: 2024-03-20)
Primary citation	Suda, A.,Koyano, H.,Hayase, T.,Hada, K.,Kawasaki, K.,Komiyama, S.,Hasegawa, K.,Fukami, T.A.,Sato, S.,Miura, T.,Ono, N.,Yamazaki, T.,Saitoh, R.,Shimma, N.,Shiratori, Y.,Tsukuda, T. Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors Bioorg.Med.Chem.Lett., 22:1136-1141, 2012 Cited by PubMed: 22192591 DOI: 10.1016/j.bmcl.2011.11.100 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.39 Å)

Structure validation