3B26

Hsp90 alpha N-terminal domain in complex with an inhibitor Ro1127850

Summary for 3B26

Entry DOI	10.2210/pdb3b26/pdb
Related	3B24 3B25 3B27 3B28
Descriptor	Heat shock protein HSP 90-alpha, 4-(1H,3H-benzo[de]isochromen-6-yl)-6-methylpyrimidin-2-amine (3 entities in total)
Functional Keywords	chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P07900
Total number of polymer chains	2
Total formula weight	51853.25
Authors	Fukami, T.A.,Ono, N. (deposition date: 2011-07-21, release date: 2011-09-14, Last modification date: 2024-03-13)
Primary citation	Miura, T.,Fukami, T.A.,Hasegawa, K.,Ono, N.,Suda, A.,Shindo, H.,Yoon, D.O.,Kim, S.J.,Na, Y.J.,Aoki, Y.,Shimma, N.,Tsukuda, T.,Shiratori, Y. Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design Bioorg.Med.Chem.Lett., 21:5778-5783, 2011 Cited by PubMed: 21875802 DOI: 10.1016/j.bmcl.2011.08.001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation