Author results

1ZBF
  • Download 1zbf
  • View 1zbf
Molmil generated image of 1zbf
CRYSTAL STRUCTURE OF B. HALODURANS RNASE H CATALYTIC DOMAIN MUTANT D132N
Descriptor:ribonuclease H-related protein, SULFATE ION
Authors:Nowotny, M., Gaidamakov, S.A., Crouch, R.J., Yang, W.
Deposit date:2005-04-08
Release date:2005-07-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structures of RNase H Bound to an RNA/DNA Hybrid: Substrate Specificity and Metal-Dependent Catalysis.
Cell(Cambridge,Mass.), 121, 2005
1ZBI
  • Download 1zbi
  • View 1zbi
Molmil generated image of 1zbi
BACILLUS HALODURANS RNASE H CATALYTIC DOMAIN MUTANT D132N IN COMPLEX WITH 12-MER RNA/DNA HYBRID
Descriptor:5'-R(*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*C)-3', 5'-D(*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*C)-3', ribonuclease H-related protein, ...
Authors:Nowotny, M., Gaidamakov, S.A., Crouch, R.J., Yang, W.
Deposit date:2005-04-08
Release date:2005-07-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structures of RNase H Bound to an RNA/DNA Hybrid: Substrate Specificity and Metal-Dependent Catalysis.
Cell(Cambridge,Mass.), 121, 2005
1ZBL
  • Download 1zbl
  • View 1zbl
Molmil generated image of 1zbl
BACILLUS HALODURANS RNASE H CATALYTIC DOMAIN MUTANT D192N IN COMPLEX WITH 12-MER RNA/DNA HYBRID
Descriptor:5'-R(*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*C)-3', 5'-D(*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*C)-3', ribonuclease H-related protein, ...
Authors:Nowotny, M., Gaidamakov, S.A., Crouch, R.J., Yang, W.
Deposit date:2005-04-08
Release date:2005-07-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structures of RNase H Bound to an RNA/DNA Hybrid: Substrate Specificity and Metal-Dependent Catalysis.
Cell(Cambridge,Mass.), 121, 2005
2G8F
  • Download 2g8f
  • View 2g8f
Molmil generated image of 2g8f
B. HALODURANS RNASE H CATALYTIC DOMAIN E188A MUTANT IN COMPLEX WITH MG2+ AND RNA/DNA HYBRID (NON-P NICK AT THE ACTIVE SITE)
Descriptor:5'-R(*UP*CP*GP*AP*CP*A)-3', 5'-D(*AP*TP*GP*TP*CP*G)-3', Ribonuclease H, ...
Authors:Nowotny, M., Yang, W.
Deposit date:2006-03-02
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release.
Embo J., 25, 2006
2G8H
  • Download 2g8h
  • View 2g8h
Molmil generated image of 2g8h
B. HALODURANS RNASE H CATALYTIC DOMAIN D192N MUTANT IN COMPLEX WITH MG2+ AND RNA/DNA HYBRID (NON-P NICK AT THE ACTIVE SITE)
Descriptor:5'-R(*UP*CP*GP*AP*CP*A)-3', 5'-D(*AP*TP*GP*TP*CP*G)-3', Ribonuclease H, ...
Authors:Nowotny, M., Yang, W.
Deposit date:2006-03-02
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release.
Embo J., 25, 2006
2G8I
  • Download 2g8i
  • View 2g8i
Molmil generated image of 2g8i
B. HALODURANS RNASE H CATALYTIC DOMAIN D192N MUTANT IN COMPLEX WITH MN2+ AND RNA/DNA HYBRID (NON-P NICK AT THE ACTIVE SITE)
Descriptor:5'-R(*UP*CP*GP*AP*CP*A)-3', 5'-D(*AP*TP*GP*TP*CP*G)-3', Ribonuclease H, ...
Authors:Nowotny, M., Yang, W.
Deposit date:2006-03-02
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release.
Embo J., 25, 2006
2G8K
  • Download 2g8k
  • View 2g8k
Molmil generated image of 2g8k
B. HALODURANS RNASE H CATALYTIC DOMAIN D192N MUTANT IN COMPLEX WITH CA2+ AND RNA/DNA HYBRID (NON-P NICK AT THE ACTIVE SITE)
Descriptor:5'-R(*UP*CP*GP*AP*CP*A)-3', 5'-D(*AP*TP*GP*TP*CP*G)-3', Ribonuclease H, ...
Authors:Nowotny, M., Yang, W.
Deposit date:2006-03-02
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release.
Embo J., 25, 2006
2G8U
  • Download 2g8u
  • View 2g8u
Molmil generated image of 2g8u
B. HALODURANS RNASE H CATALYTIC DOMAIN D132N MUTANT IN COMPLEX WITH MG2+ AND RNA/DNA HYBRID (NON-P NICK AT THE ACTIVE SITE)
Descriptor:5'-R(*UP*CP*GP*AP*CP*A)-3', 5'-D(*AP*TP*GP*TP*CP*G)-3', Ribonuclease H, ...
Authors:Nowotny, M., Yang, W.
Deposit date:2006-03-03
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release.
Embo J., 25, 2006
2G8V
  • Download 2g8v
  • View 2g8v
Molmil generated image of 2g8v
B. HALODURANS RNASE H CATALYTIC DOMAIN E188A MUTANT IN COMPLEX WITH MG2+ AND RNA/DNA HYBRID (REACTION PRODUCT)
Descriptor:5'-R(P*UP*CP*GP*AP*CP*A)-3', 5'-D(*AP*TP*GP*TP*CP*G)-3', Ribonuclease H, ...
Authors:Nowotny, M., Yang, W.
Deposit date:2006-03-03
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release.
Embo J., 25, 2006
2G8W
  • Download 2g8w
  • View 2g8w
Molmil generated image of 2g8w
B. HALODURANS RNASE H CATALYTIC DOMAIN E188A MUTANT IN COMPLEX WITH CA2+ AND RNA/DNA HYBRID
Descriptor:5'-R(P*UP*CP*GP*AP*CP*A)-3', 5'-D(*AP*TP*GP*TP*CP*G)-3', Ribonuclease H, ...
Authors:Nowotny, M., Yang, W.
Deposit date:2006-03-03
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release.
Embo J., 25, 2006
2QK9
  • Download 2qk9
  • View 2qk9
Molmil generated image of 2qk9
HUMAN RNASE H CATALYTIC DOMAIN MUTANT D210N IN COMPLEX WITH 18-MER RNA/DNA HYBRID
Descriptor:5'-R(*AP*GP*UP*GP*CP*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*CP*C)-3', 5'-D(*GP*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*CP*GP*CP*AP*CP*T)-3', Ribonuclease H1, ...
Authors:Nowotny, M., Gaidamakov, S.A., Ghirlando, R., Cerritelli, S.M., Crouch, R.J., Yang, W.
Deposit date:2007-07-10
Release date:2007-11-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription
Mol.Cell, 28, 2007
2QKB
  • Download 2qkb
  • View 2qkb
Molmil generated image of 2qkb
HUMAN RNASE H CATALYTIC DOMAIN MUTANT D210N IN COMPLEX WITH 20-MER RNA/DNA HYBRID
Descriptor:5'-R(*GP*GP*AP*GP*UP*GP*CP*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*CP*C)-3'), 5'-D(*DGP*DGP*DAP*DAP*DTP*DCP*DAP*DGP*DGP*DTP*DGP*DTP*DCP*DGP*DCP*DAP*DCP*DTP*DCP*DT)-3', Ribonuclease H1, ...
Authors:Nowotny, M., Gaidamakov, S.A., Ghirlando, R., Cerritelli, S.M., Crouch, R.J., Yang, W.
Deposit date:2007-07-10
Release date:2007-11-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription
Mol.Cell, 28, 2007
2QKK
  • Download 2qkk
  • View 2qkk
Molmil generated image of 2qkk
HUMAN RNASE H CATALYTIC DOMAIN MUTANT D210N IN COMPLEX WITH 14-MER RNA/DNA HYBRID
Descriptor:5'-R(*CP*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*CP*C)-3', 5'-D(*GP*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*CP*G)-3', Ribonuclease H1, ...
Authors:Nowotny, M., Gaidamakov, S.A., Ghirlando, R., Cerritelli, S.M., Crouch, R.J., Yang, W.
Deposit date:2007-07-11
Release date:2007-11-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription
Mol.Cell, 28, 2007
3BSU
  • Download 3bsu
  • View 3bsu
Molmil generated image of 3bsu
HYBRID-BINDING DOMAIN OF HUMAN RNASE H1 IN COMPLEX WITH 12-MER RNA/DNA
Descriptor:RNA (5'-R(*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*C)-3'), DNA (5'-D(*DGP*DAP*DAP*DTP*DCP*DAP*DGP*DGP*(5IU)P*DGP*DTP*DC)-3'), Ribonuclease H1, ...
Authors:Nowotny, M., Cerritelli, S.M., Ghirlando, R., Gaidamakov, S.A., Crouch, R.J., Yang, W.
Deposit date:2007-12-26
Release date:2008-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Specific recognition of RNA/DNA hybrid and enhancement of human RNase H1 activity by HBD.
Embo J., 27, 2008
6F3H
  • Download 6f3h
  • View 6f3h
Molmil generated image of 6f3h
CRYSTAL STRUCTURE OF DSS1 EXORIBONUCLEASE ACTIVE SITE MUTANT D477N FROM CANDIDA GLABRATA
Descriptor:Exoribonuclease II, mitochondrial, RNA (5'-R(P*AP*GP*AP*UP*AP*C)-3'), ...
Authors:Razew, M., Nowak, E., Nowotny, M.
Deposit date:2017-11-28
Release date:2018-01-17
Method:X-RAY DIFFRACTION (2.703 Å)
Cite:Structural analysis of mtEXO mitochondrial RNA degradosome reveals tight coupling of nuclease and helicase components.
Nat Commun, 9, 2018
6F4A
  • Download 6f4a
  • View 6f4a
Molmil generated image of 6f4a
YEAST MITOCHONDRIAL RNA DEGRADOSOME COMPLEX MTEXO
Descriptor:Exoribonuclease II, mitochondrial, Suv3 helicase, ...
Authors:Razew, M., Nowak, E., Nowotny, M.
Deposit date:2017-11-29
Release date:2018-01-17
Method:X-RAY DIFFRACTION (3.55 Å)
Cite:Structural analysis of mtEXO mitochondrial RNA degradosome reveals tight coupling of nuclease and helicase components.
Nat Commun, 9, 2018
3PIH
  • Download 3pih
  • View 3pih
Molmil generated image of 3pih
T. MARITIMA UVRA IN COMPLEX WITH FLUORESCEIN-MODIFIED DNA
Descriptor:UvrABC system protein A, DNA (32-MER), PYROPHOSPHATE, ...
Authors:Jaciuk, M., Nowak, E., Nowotny, M.
Deposit date:2010-11-06
Release date:2011-01-19
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of UvrA nucleotide excision repair protein in complex with modified DNA.
Nat.Struct.Mol.Biol., 18, 2011
3PUF
  • Download 3puf
  • View 3puf
Molmil generated image of 3puf
CRYSTAL STRUCTURE OF HUMAN RNASE H2 COMPLEX
Descriptor:Ribonuclease H2 subunit A, Ribonuclease H2 subunit B, Ribonuclease H2 subunit C
Authors:Figiel, M., Chon, H., Cerritelli, S.M., Cybulska, M., Crouch, R.J., Nowotny, M.
Deposit date:2010-12-04
Release date:2010-12-22
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The structural and biochemical characterization of human RNase H2 complex reveals the molecular basis for substrate recognition and Aicardi-Goutieres syndrome defects.
J.Biol.Chem., 286, 2011
4HHT
  • Download 4hht
  • View 4hht
Molmil generated image of 4hht
T. MARITIMA RNASE H2 G21S IN COMPLEX WITH NUCLEIC ACID SUBSTRATE AND CALCIUM IONS
Descriptor:Ribonuclease HII, DNA (5'-D(*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*C)-3'), DNA/RNA (5'-D(*GP*AP*CP*AP*C)-R(P*C)-D(P*TP*GP*AP*TP*TP*C)-3'), ...
Authors:Rychlik, M.P., Nowotny, M.
Deposit date:2012-10-10
Release date:2013-02-06
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:RNase H2 roles in genome integrity revealed by unlinking its activities.
Nucleic Acids Res., 41, 2013
4N48
  • Download 4n48
  • View 4n48
Molmil generated image of 4n48
CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1 PROTEIN IN COMPLEX WITH CAPPED RNA FRAGMENT
Descriptor:Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1, capped RNA, S-ADENOSYLMETHIONINE, ...
Authors:Smietanski, M., Werener, M., Purta, E., Kaminska, K.H., Stepinski, J., Darzynkiewicz, E., Nowotny, M., Bujnicki, J.M.
Deposit date:2013-10-08
Release date:2014-01-22
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.704 Å)
Cite:Structural analysis of human 2'-O-ribose methyltransferases involved in mRNA cap structure formation.
Nat Commun, 5, 2014
4N49
  • Download 4n49
  • View 4n49
Molmil generated image of 4n49
CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1 PROTEIN IN COMPLEX WITH M7GPPPG AND SAM
Descriptor:Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1, S-ADENOSYLMETHIONINE, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Smietanski, M., Werener, M., Purta, E., Kaminska, K.H., Stepinski, J., Darzynkiewicz, E., Nowotny, M., Bujnicki, J.M.
Deposit date:2013-10-08
Release date:2014-01-22
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural analysis of human 2'-O-ribose methyltransferases involved in mRNA cap structure formation.
Nat Commun, 5, 2014
4N4A
  • Download 4n4a
  • View 4n4a
Molmil generated image of 4n4a
CYSTAL STRUCTURE OF CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1
Descriptor:Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Authors:Smietanski, M., Werener, M., Purta, E., Kaminska, K.H., Stepinski, J., Darzynkiewicz, E., Nowotny, M., Bujnicki, J.M.
Deposit date:2013-10-08
Release date:2014-01-22
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural analysis of human 2'-O-ribose methyltransferases involved in mRNA cap structure formation.
Nat Commun, 5, 2014
4PY5
  • Download 4py5
  • View 4py5
Molmil generated image of 4py5
THERMOVIBRIO AMMONIFICANS RNASE H3 IN COMPLEX WITH 19-MER RNA/DNA
Descriptor:Ribonuclease, 5'-R(*GP*AP*GP*UP*GP*CP*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*CP*C)-3', 5'-D(*GP*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*CP*GP*CP*AP*CP*TP*C)-3', ...
Authors:Figiel, M., Nowotny, M.
Deposit date:2014-03-26
Release date:2014-07-30
Last modified:2014-10-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of RNase H3-substrate complex reveals parallel evolution of RNA/DNA hybrid recognition.
Nucleic Acids Res., 42, 2014
4Q0R
  • Download 4q0r
  • View 4q0r
Molmil generated image of 4q0r
THE CATALYTIC CORE OF RAD2 (COMPLEX I)
Descriptor:DNA repair protein RAD2, DNA (5'-D(*CP*TP*GP*AP*GP*TP*CP*AP*GP*AP*GP*CP*AP*AP*A)-3')
Authors:Mietus, M., Nowak, E., Jaciuk, M., Kustosz, P., Nowotny, M.
Deposit date:2014-04-02
Release date:2014-08-27
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding.
Nucleic Acids Res., 42, 2014
4Q0W
  • Download 4q0w
  • View 4q0w
Molmil generated image of 4q0w
HE CATALYTIC CORE OF RAD2 IN COMPLEX WITH DNA SUBSTRATE (COMPLEX II)
Descriptor:DNA repair protein RAD2, DNA (5'-D(*TP*TP*TP*GP*AP*TP*CP*CP*GP*TP*CP*CP*AP*CP*CP*TP*TP*T)-3'), DNA (5'-D(*TP*TP*AP*GP*GP*TP*GP*GP*AP*CP*GP*GP*AP*TP*CP*AP*TP*T)-3'), ...
Authors:Mietus, M., Nowak, E., Jaciuk, M., Kustosz, P., Nowotny, M.
Deposit date:2014-04-02
Release date:2014-08-27
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding.
Nucleic Acids Res., 42, 2014
<123>