3BSU

Hybrid-binding domain of human RNase H1 in complex with 12-mer RNA/DNA

Summary for 3BSU

• Entry DOI: 10.2210/pdb3bsu/pdb
• Descriptor: RNA (5'-R(*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*C)-3'), DNA (5'-D(*DGP*DAP*DAP*DTP*DCP*DAP*DGP*DGP*(5IU)P*DGP*DTP*DC)-3'), Ribonuclease H1, ... (5 entities in total)
• Functional Keywords: rnase h, rna/dna hybrid, dsrna, hydrolase-rna-dna complex, hydrolase/rna/dna
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm (Potential): O60930
• Total number of polymer chains: 10
• Total formula weight: 52404.26

Authors

Nowotny, M.,Cerritelli, S.M.,Ghirlando, R.,Gaidamakov, S.A.,Crouch, R.J.,Yang, W. (deposition date: 2007-12-26, release date: 2008-03-25, Last modification date: 2024-02-21)

• Primary citation: Nowotny, M.,Cerritelli, S.M.,Ghirlando, R.,Gaidamakov, S.A.,Crouch, R.J.,Yang, W.; Specific recognition of RNA/DNA hybrid and enhancement of human RNase H1 activity by HBD.; Embo J., 27:1172-1181, 2008; PubMed: 18337749; DOI: 10.1038/emboj.2008.44

Experimental method

X-RAY DIFFRACTION (2.1 Å)