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1S5H
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BU of 1s5h by Molmil
Potassium Channel Kcsa-Fab Complex T75C mutant in K+
Descriptor: ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, DIACYL GLYCEROL, ...
Authors:Mackinnon, R, Zhou, M.
Deposit date:2004-01-20
Release date:2004-05-18
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A mutant KcsA K(+) channel with altered conduction properties and selectivity filter ion distribution.
J.Mol.Biol., 338, 2004
4JTA
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BU of 4jta by Molmil
Crystal structure of Kv1.2-2.1 paddle chimera channel in complex with Charybdotoxin
Descriptor: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION, ...
Authors:MacKinnon, R, Banerjee, A, Lee, A, Campbell, E.
Deposit date:2013-03-23
Release date:2013-06-12
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel.
Elife, 2, 2013
5VMS
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BU of 5vms by Molmil
CryoEM structure of Xenopus KCNQ1 channel
Descriptor: CALCIUM ION, Calmodulin, Potassium voltage-gated channel subfamily KQT member 1
Authors:Mackinnon, R, Sun, J.
Deposit date:2017-04-28
Release date:2017-06-07
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-EM Structure of a KCNQ1/CaM Complex Reveals Insights into Congenital Long QT Syndrome.
Cell, 169, 2017
6V00
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BU of 6v00 by Molmil
structure of human KCNQ1-KCNE3-CaM complex
Descriptor: CALCIUM ION, Calmodulin-1, MCherry fluorescent protein,Potassium voltage-gated channel subfamily E member 3, ...
Authors:Mackinnon, R, Sun, J.
Deposit date:2019-11-16
Release date:2019-12-04
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural Basis of Human KCNQ1 Modulation and Gating.
Cell, 180, 2020
6UZZ
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BU of 6uzz by Molmil
structure of human KCNQ1-CaM complex
Descriptor: CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 1
Authors:Mackinnon, R, Sun, J.
Deposit date:2019-11-16
Release date:2019-12-04
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural Basis of Human KCNQ1 Modulation and Gating.
Cell, 180, 2020
6V01
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BU of 6v01 by Molmil
structure of human KCNQ1-KCNE3-CaM complex with PIP2
Descriptor: CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily E member 3, ...
Authors:Mackinnon, R, Sun, J.
Deposit date:2019-11-18
Release date:2019-12-04
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural Basis of Human KCNQ1 Modulation and Gating.
Cell, 180, 2020
5TJ6
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BU of 5tj6 by Molmil
Ca2+ bound aplysia Slo1
Descriptor: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CALCIUM ION, High conductance calcium-activated potassium channel, ...
Authors:MacKinnon, R, Tao, X, Hite, R.K.
Deposit date:2016-10-03
Release date:2016-12-14
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM structure of the open high-conductance Ca(2+)-activated K(+) channel.
Nature, 541, 2017
5TJI
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BU of 5tji by Molmil
Ca2+ bound aplysia Slo1
Descriptor: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, High conductance calcium-activated potassium channel
Authors:MacKinnon, R, Tao, X, Hite, R.K.
Deposit date:2016-10-04
Release date:2016-12-28
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural basis for gating the high-conductance Ca(2+)-activated K(+) channel.
Nature, 541, 2017
1QRQ
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BU of 1qrq by Molmil
STRUCTURE OF A VOLTAGE-DEPENDENT K+ CHANNEL BETA SUBUNIT
Descriptor: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROTEIN (KV BETA2 PROTEIN)
Authors:Gulbis, J.M, Mann, S, MacKinnon, R.
Deposit date:1999-06-15
Release date:1999-10-27
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of a voltage-dependent K+ channel beta subunit.
Cell(Cambridge,Mass.), 97, 1999
9BQ2
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BU of 9bq2 by Molmil
Structure of the flotillin complex in a native membrane environment
Descriptor: Flotillin-1, Flotillin-2
Authors:Fu, Z, MacKinnon, R.
Deposit date:2024-05-08
Release date:2024-07-24
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of the flotillin complex in a native membrane environment.
Proc.Natl.Acad.Sci.USA, 121, 2024
2A79
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BU of 2a79 by Molmil
Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
Descriptor: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION, Potassium voltage-gated channel subfamily A member 2, ...
Authors:Long, S.B, Campbell, E.B, MacKinnon, R.
Deposit date:2005-07-05
Release date:2005-07-12
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of a mammalian voltage-dependent Shaker family K+ channel.
Science, 309, 2005
2KYH
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BU of 2kyh by Molmil
Solution structure of the voltage-sensing domain of KvAP
Descriptor: Voltage-gated potassium channel
Authors:Butterwick, J.A, MacKinnon, R.
Deposit date:2010-05-26
Release date:2010-09-29
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Solution Structure and Phospholipid Interactions of the Isolated Voltage-Sensor Domain from KvAP.
J.Mol.Biol., 403, 2010
6PBY
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BU of 6pby by Molmil
Single particle cryo-EM structure of the voltage-gated K+ channel Eag1 3-13 deletion mutant bound to calmodulin (conformation 1)
Descriptor: Calmodulin-1, Potassium voltage-gated channel subfamily H member 1
Authors:Whicher, J.R, MacKinnon, R.
Deposit date:2019-06-14
Release date:2019-09-18
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.67 Å)
Cite:Regulation of Eag1 gating by its intracellular domains.
Elife, 8, 2019
2A0L
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BU of 2a0l by Molmil
Crystal structure of KvAP-33H1 Fv complex
Descriptor: 33H1 Fv fragment, POTASSIUM ION, Voltage-gated potassium channel
Authors:Lee, S.Y, Lee, A, Chen, J, Mackinnon, R.
Deposit date:2005-06-16
Release date:2005-11-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Structure of the KvAP voltage-dependent K+ channel and its dependence on the lipid membrane.
Proc.Natl.Acad.Sci.Usa, 102, 2005
2R9R
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BU of 2r9r by Molmil
Shaker family voltage dependent potassium channel (kv1.2-kv2.1 paddle chimera channel) in association with beta subunit
Descriptor: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION, ...
Authors:Long, S.B, Tao, X, Campbell, E.B, Mackinnon, R.
Deposit date:2007-09-13
Release date:2007-11-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment.
Nature, 450, 2007
5K7L
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BU of 5k7l by Molmil
Single particle cryo-EM structure of the voltage-gated K+ channel Eag1 bound to the channel inhibitor calmodulin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Calmodulin, ...
Authors:Whicher, J.R, MacKinnon, R.
Deposit date:2016-05-26
Release date:2016-08-17
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.78 Å)
Cite:Structure of the voltage-gated K+ channel Eag1 reveals an alternative voltage sensing mechanism.
Science, 353, 2016
6B3R
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BU of 6b3r by Molmil
Structure of the mechanosensitive channel Piezo1
Descriptor: Piezo-type mechanosensitive ion channel component 1, unknown fragment
Authors:Guo, Y.R, MacKinnon, R.
Deposit date:2017-09-22
Release date:2017-12-20
Last modified:2018-05-16
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure-based membrane dome mechanism for Piezo mechanosensitivity.
Elife, 6, 2017
4FG6
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BU of 4fg6 by Molmil
Structure of EcCLC E148A mutant in Glutamate
Descriptor: Fab fragment (Heavy chain), Fab fragment (Light chain), H(+)/Cl(-) exchange transporter ClcA
Authors:Feng, L, MacKinnon, R.
Deposit date:2012-06-04
Release date:2012-07-04
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.019 Å)
Cite:Molecular mechanism of proton transport in CLC Cl-/H+ exchange transporters.
Proc.Natl.Acad.Sci.USA, 109, 2012
6XIS
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BU of 6xis by Molmil
Cryo-EM structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in apo form
Descriptor: G protein-activated inward rectifier potassium channel 2
Authors:Niu, Y, Tao, X, MacKinnon, R.
Deposit date:2020-06-21
Release date:2020-10-07
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM analysis of PIP 2 regulation in mammalian GIRK channels.
Elife, 9, 2020
6XIT
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BU of 6xit by Molmil
Cryo-EM structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in complex with PIP2
Descriptor: G protein-activated inward rectifier potassium channel 2, POTASSIUM ION, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
Authors:Niu, Y, Tao, X, MacKinnon, R.
Deposit date:2020-06-21
Release date:2020-10-07
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM analysis of PIP 2 regulation in mammalian GIRK channels.
Elife, 9, 2020
3ORG
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BU of 3org by Molmil
Crystal Structure of a eukaryotic CLC transporter
Descriptor: CHLORIDE ION, CmCLC
Authors:Feng, L, MacKinnon, R.
Deposit date:2010-09-07
Release date:2010-10-06
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure of a eukaryotic CLC transporter defines an intermediate state in the transport cycle.
Science, 330, 2010
7S5Y
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BU of 7s5y by Molmil
Human KATP channel in open conformation, focused on Kir and one SUR, position 2
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ...
Authors:Zhao, C, MacKinnon, R.
Deposit date:2021-09-12
Release date:2021-12-01
Last modified:2021-12-08
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Molecular structure of an open human K ATP channel.
Proc.Natl.Acad.Sci.USA, 118, 2021
7S5Z
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BU of 7s5z by Molmil
Human KATP channel in open conformation, focused on Kir and one SUR, position 3
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ...
Authors:Zhao, C, MacKinnon, R.
Deposit date:2021-09-12
Release date:2021-12-01
Last modified:2021-12-08
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Molecular structure of an open human K ATP channel.
Proc.Natl.Acad.Sci.USA, 118, 2021
4WFH
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BU of 4wfh by Molmil
Human TRAAK K+ channel in a Tl+ bound nonconductive conformation
Descriptor: ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
Authors:Brohawn, S.G, MacKinnon, R.
Deposit date:2014-09-15
Release date:2014-12-03
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
Nature, 516, 2014
4WFG
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BU of 4wfg by Molmil
Human TRAAK K+ channel in a Tl+ bound conductive conformation
Descriptor: ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
Authors:Brohawn, S.G, MacKinnon, R.
Deposit date:2014-09-15
Release date:2014-12-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
Nature, 516, 2014

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