Author results

1DGQ
  • Download 1dgq
  • View 1dgq
Molmil generated image of 1dgq
NMR SOLUTION STRUCTURE OF THE INSERTED DOMAIN OF HUMAN LEUKOCYTE FUNCTION ASSOCIATED ANTIGEN-1
Descriptor:LEUKOCYTE FUNCTION ASSOCIATED ANTIGEN-1
Authors:Legge, G.B., Kriwacki, R.W., Chung, J., Hommel, U., Ramage, P., Case, D.A., Dyson, H.J., Wright, P.E.
Deposit date:1999-11-24
Release date:2000-02-03
Last modified:2014-11-12
Method:SOLUTION NMR
Cite:NMR solution structure of the inserted domain of human leukocyte function associated antigen-1.
J.Mol.Biol., 295, 2000
1HN3
  • Download 1hn3
  • View 1hn3
Molmil generated image of 1hn3
SOLUTION STRUCTURE OF THE N-TERMINAL 37 AMINO ACIDS OF THE MOUSE ARF TUMOR SUPPRESSOR PROTEIN
Descriptor:P19 ARF PROTEIN
Authors:DiGiammarino, E.L., Filippov, I., Weber, J.D., Bothner, B., Kriwacki, R.W.
Deposit date:2000-12-05
Release date:2001-12-05
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the p53 regulatory domain of the p19Arf tumor suppressor protein.
Biochemistry, 40, 2001
1I1S
  • Download 1i1s
  • View 1i1s
Molmil generated image of 1i1s
SOLUTION STRUCTURE OF THE TRANSCRIPTIONAL ACTIVATION DOMAIN OF THE BACTERIOPHAGE T4 PROTEIN MOTA
Descriptor:MOTA
Authors:Li, N., Zhang, W., White, S.W., Kriwacki, R.W.
Deposit date:2001-02-02
Release date:2001-02-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the transcriptional activation domain of the bacteriophage T4 protein, MotA.
Biochemistry, 40, 2001
1N14
  • Download 1n14
  • View 1n14
Molmil generated image of 1n14
STRUCTURE AND DYNAMICS OF THIOGUANINE-MODIFIED DUPLEX DNA IN COMPARISON WITH UNMODIFIED DNA; STRUCTURE OF UNMODIFIED DUPLEX DNA
Descriptor:5'-D(*GP*CP*TP*AP*AP*GP*GP*AP*AP*AP*GP*CP*C)-3', 5'-D(*GP*GP*CP*TP*TP*TP*CP*CP*TP*TP*AP*GP*C)-3'
Authors:Somerville, L., Krynetski, E.Y., Krynetskaia, N.F., Beger, R.D., Zhang, W., Marhefka, C.A., Evans, W.E., Kriwacki, R.W.
Deposit date:2002-10-16
Release date:2002-10-23
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and dynamics of thioguanine-modified duplex DNA
J.Biol.Chem., 278, 2003
1N17
  • Download 1n17
  • View 1n17
Molmil generated image of 1n17
STRUCTURE AND DYNAMICS OF THIOGUANINE-MODIFIED DUPLEX DNA
Descriptor:5'-D(*GP*CP*TP*AP*AP*GP*(S6G)P*AP*AP*AP*GP*CP*C)-3', 5'-D(*GP*GP*CP*TP*TP*TP*CP*CP*TP*TP*AP*GP*C)-3'
Authors:Somerville, L., Krynetski, E.Y., Krynetskaia, N.F., Beger, R.D., Zhang, W., Marhefka, C.A., Evans, W.E., Kriwacki, R.W.
Deposit date:2002-10-16
Release date:2002-10-23
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and dynamics of thioguanine-modified duplex DNA
J.Biol.Chem., 278, 2003
1SP1
  • Download 1sp1
  • View 1sp1
Molmil generated image of 1sp1
NMR STRUCTURE OF A ZINC FINGER DOMAIN FROM TRANSCRIPTION FACTOR SP1F3, MINIMIZED AVERAGE STRUCTURE
Descriptor:SP1F3, ZINC ION
Authors:Narayan, V.A., Kriwacki, R.W., Caradonna, J.P.
Deposit date:1996-11-21
Release date:1997-04-21
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structures of zinc finger domains from transcription factor Sp1. Insights into sequence-specific protein-DNA recognition.
J.Biol.Chem., 272, 1997
1SP2
  • Download 1sp2
  • View 1sp2
Molmil generated image of 1sp2
NMR STRUCTURE OF A ZINC FINGER DOMAIN FROM TRANSCRIPTION FACTOR SP1F2, MINIMIZED AVERAGE STRUCTURE
Descriptor:SP1F2, ZINC ION
Authors:Narayan, V.A., Kriwacki, R.W., Caradonna, J.P.
Deposit date:1996-11-21
Release date:1997-04-21
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structures of zinc finger domains from transcription factor Sp1. Insights into sequence-specific protein-DNA recognition.
J.Biol.Chem., 272, 1997
1W9R
  • Download 1w9r
  • View 1w9r
Molmil generated image of 1w9r
SOLUTION STRUCTURE OF CHOLINE BINDING PROTEIN A, DOMAIN R2, THE MAJOR ADHESIN OF STREPTOCOCCUS PNEUMONIAE
Descriptor:CHOLINE BINDING PROTEIN A
Authors:Luo, R., Mann, B., Lewis, W.S., Rowe, A., Heath, R., Stewart, M.L., Hamburger, A.E., Bjorkman, P.J., Sivakolundu, S., Lacy, E.R., Tuomanen, E., Kriwacki, R.W.
Deposit date:2004-10-15
Release date:2005-02-22
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of Choline Binding Protein A, the Major Adhesin of Streptococcus Pneumoniae
Embo J., 24, 2005
2DCO
  • Download 2dco
  • View 2dco
Molmil generated image of 2dco
S1P4 FIRST EXTRACELLULAR LOOP PEPTIDOMIMETIC
Descriptor:S1P4 First Extracellular Loop Peptidomimetic
Authors:Pham, T.C.T., Kriwacki, R.W., Parrill, A.L.
Deposit date:2006-01-11
Release date:2007-01-23
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Peptide design and structural characterization of a GPCR loop mimetic
Biopolymers, 86, 2007
2M03
  • Download 2m03
  • View 2m03
Molmil generated image of 2m03
SOLUTION STRUCTURE OF BCL-XL DETERMINED WITH SELECTIVE ISOTOPE LABELLING OF I,L,V SIDECHAINS
Descriptor:Bcl-2-like protein 1
Authors:Viacava Follis, A., Royappa, G., Kriwacki, R.W.
Deposit date:2012-10-19
Release date:2013-01-30
Last modified:2013-03-06
Method:SOLUTION NMR
Cite:PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis.
Nat.Chem.Biol., 9, 2013
2M04
  • Download 2m04
  • View 2m04
Molmil generated image of 2m04
SOLUTION STRUCTURE OF BCL-XL IN COMPLEX WITH PUMA BH3 PEPTIDE
Descriptor:Bcl-2-like protein 1, Bcl-2-binding component 3
Authors:Viacava Follis, A., Royappa, G., Kriwacki, R.W.
Deposit date:2012-10-19
Release date:2013-01-30
Last modified:2013-03-06
Method:SOLUTION NMR
Cite:PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis.
Nat.Chem.Biol., 9, 2013
2M5B
  • Download 2m5b
  • View 2m5b
Molmil generated image of 2m5b
THE NMR STRUCTURE OF THE BID-BAK COMPLEX
Descriptor:Bcl-2 homologous antagonist/killer, human_BID_BH3_SAHB
Authors:Moldoveanu, T., Grace, C.R., Kriwacki, R.W., Green, D.R.
Deposit date:2013-02-19
Release date:2013-04-17
Last modified:2013-05-22
Method:SOLUTION NMR
Cite:BID-induced structural changes in BAK promote apoptosis.
Nat.Struct.Mol.Biol., 20, 2013
2M6N
  • Download 2m6n
  • View 2m6n
Molmil generated image of 2m6n
3D SOLUTION STRUCTURE OF EMI1 (EARLY MITOTIC INHIBITOR 1)
Descriptor:F-box only protein 5, ZINC ION
Authors:Frye, J.J., Brown, N.G., Petzold, G., Watson, E.R., Royappa, G.R., Nourse, A., Jarvis, M., Kriwacki, R.W., Peters, J., Stark, H., Schulman, B.A.
Deposit date:2013-04-06
Release date:2013-05-29
Last modified:2013-07-17
Method:SOLUTION NMR
Cite:Electron microscopy structure of human APC/C(CDH1)-EMI1 reveals multimodal mechanism of E3 ligase shutdown.
Nat.Struct.Mol.Biol., 20, 2013
2ME8
  • Download 2me8
  • View 2me8
Molmil generated image of 2me8
SOLUTION STRUCTURE OF BCL-XL IN ITS P53-BOUND CONFORMATION DETERMINED WITH SELECTIVE ISOTOPE LABELLING OF I,L,V SIDECHAINS
Descriptor:Bcl-2-like protein 1
Authors:Viacava Follis, A., Grace, C.R., Kriwacki, R.W.
Deposit date:2013-09-25
Release date:2014-04-30
Last modified:2014-07-09
Method:SOLUTION NMR
Cite:The DNA-binding domain mediates both nuclear and cytosolic functions of p53.
Nat.Struct.Mol.Biol., 21, 2014
2ME9
  • Download 2me9
  • View 2me9
Molmil generated image of 2me9
SOLUTION STRUCTURE OF BCL-XL CONTAINING THE ALPHA1-ALPHA2 DISORDERED LOOP DETERMINED WITH SELECTIVE ISOTOPE LABELLING OF I,L,V SIDECHAINS
Descriptor:Bcl-2-like protein 1
Authors:Viacava Follis, A., Grace, C.R., Kriwacki, R.W.
Deposit date:2013-09-25
Release date:2014-04-30
Last modified:2014-07-09
Method:SOLUTION NMR
Cite:The DNA-binding domain mediates both nuclear and cytosolic functions of p53.
Nat.Struct.Mol.Biol., 21, 2014
2MEJ
  • Download 2mej
  • View 2mej
Molmil generated image of 2mej
SOLUTION STRUCTURE OF THE COMPLEX BETWEEN BCL-XL AND THE P53 CORE DOMAIN DETERMINED WITH PRE RESTRAINTS
Descriptor:Bcl-2-like protein 1, Cellular tumor antigen p53, ZINC ION
Authors:Viacava Follis, A., Grace, C.R., Kriwacki, R.W.
Deposit date:2013-09-25
Release date:2014-04-30
Last modified:2016-04-27
Method:SOLUTION NMR
Cite:The DNA-binding domain mediates both nuclear and cytosolic functions of p53.
Nat.Struct.Mol.Biol., 21, 2014
2N06
  • Download 2n06
  • View 2n06
Molmil generated image of 2n06
MDMX-298
Descriptor:Protein Mdm4, 4-[[(4S,5R)-5-(4-chlorophenyl)-4-(3-methoxyphenyl)-2-(4-methoxy-2-propan-2-yloxy-phenyl)-4,5-dihydroimidazol-1-yl]carbonyl]piperazin-2-one
Authors:Grace, C.R., Kriwacki, R.W.
Deposit date:2015-03-04
Release date:2016-01-27
Last modified:2016-05-04
Method:SOLUTION NMR
Cite:Monitoring Ligand-Induced Protein Ordering in Drug Discovery.
J.Mol.Biol., 428, 2016
2N0U
  • Download 2n0u
  • View 2n0u
Molmil generated image of 2n0u
MDMX-057
Descriptor:Protein Mdm4, 4-[(4S,5R)-4-(3-chlorophenyl)-5-(4-chlorophenyl)-1-(3-oxidanylidenepiperazin-1-yl)carbonyl-4,5-dihydroimidazol-2-yl]-3-propan-2-yloxy-benzenecarbonitrile
Authors:Grace, C.R., Kriwacki, R.W.
Deposit date:2015-03-17
Release date:2016-01-27
Last modified:2016-05-04
Method:SOLUTION NMR
Cite:Monitoring Ligand-Induced Protein Ordering in Drug Discovery.
J.Mol.Biol., 428, 2016
2N0W
  • Download 2n0w
  • View 2n0w
Molmil generated image of 2n0w
MDMX-SJ212
Descriptor:Protein Mdm4, 4-({(4S,5R)-4-(5-bromo-2-fluorophenyl)-5-(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one
Authors:Grace, C.R., Kriwacki, R.W.
Deposit date:2015-03-17
Release date:2016-01-27
Last modified:2016-05-04
Method:SOLUTION NMR
Cite:Monitoring Ligand-Induced Protein Ordering in Drug Discovery.
J.Mol.Biol., 428, 2016
2N14
  • Download 2n14
  • View 2n14
Molmil generated image of 2n14
MDMX-295
Descriptor:Protein Mdm4, 4-({(4S,5R)-4-(3-chlorophenyl)-5-(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one
Authors:Grace, C.R., Kriwacki, R.W.
Deposit date:2015-03-20
Release date:2016-01-27
Last modified:2016-05-04
Method:SOLUTION NMR
Cite:Monitoring Ligand-Induced Protein Ordering in Drug Discovery.
J.Mol.Biol., 428, 2016
3O2P
  • Download 3o2p
  • View 3o2p
Molmil generated image of 3o2p
A DUAL E3 MECHANISM FOR RUB1 LIGATION TO CDC53: DCN1(P)-CDC53(WHB)
Descriptor:Defective in cullin neddylation protein 1, Cell division control protein 53, GLYCEROL
Authors:Scott, D.C., Monda, J.K., Grace, C.R.R., Duda, D.M., Kriwacki, R.W., Kurz, T., Schulman, B.A.
Deposit date:2010-07-22
Release date:2010-09-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.233 Å)
Cite:A dual E3 mechanism for Rub1 ligation to Cdc53.
Mol.Cell, 39, 2010
3O2U
  • Download 3o2u
  • View 3o2u
Molmil generated image of 3o2u
S. CEREVISIAE UBC12
Descriptor:NEDD8-conjugating enzyme UBC12, GLYCEROL
Authors:Scott, D.C., Monda, J.K., Grace, C.R.R., Duda, D.M., Kriwacki, R.W., Kurz, T., Schulman, B.A.
Deposit date:2010-07-22
Release date:2010-09-15
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.003 Å)
Cite:A dual E3 mechanism for Rub1 ligation to Cdc53.
Mol.Cell, 39, 2010
3O6B
  • Download 3o6b
  • View 3o6b
Molmil generated image of 3o6b
A DUAL E3 MECHANISM FOR RUB1 LIGATION TO CDC53: DCN1(P)-CDC53(WHB) LOW RESOLUTION
Descriptor:Defective in cullin neddylation protein 1, Cell division control protein 53
Authors:Scott, D.C., Monda, J.K., Grace, C.R.R., Duda, D.M., Kriwacki, R.W., Kurz, T., Schulman, B.A.
Deposit date:2010-07-28
Release date:2010-09-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A dual E3 mechanism for Rub1 ligation to Cdc53.
Mol.Cell, 39, 2010
3RTR
  • Download 3rtr
  • View 3rtr
Molmil generated image of 3rtr
A RING E3-SUBSTRATE COMPLEX POISED FOR UBIQUITIN-LIKE PROTEIN TRANSFER: STRUCTURAL INSIGHTS INTO CULLIN-RING LIGASES
Descriptor:Cullin-1, E3 ubiquitin-protein ligase RBX1, ZINC ION
Authors:Calabrese, M.F., Scott, D.C., Duda, D.M., Grace, C.R., Kurinov, I., Kriwacki, R.W., Schulman, B.A.
Deposit date:2011-05-03
Release date:2011-07-20
Last modified:2011-08-24
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases.
Nat.Struct.Mol.Biol., 18, 2011
4N8M
  • Download 4n8m
  • View 4n8m
Molmil generated image of 4n8m
STRUCTURAL POLYMORPHISM IN THE N-TERMINAL OLIGOMERIZATION DOMAIN OF NPM1
Descriptor:Nucleophosmin, COBALT (II) ION
Authors:Mitrea, D., Royappa, G., Buljan, M., Yun, M., Pytel, N., Satumba, J., Nourse, A., Park, C., Babu, M.M., White, S.W., Kriwacki, R.W.
Deposit date:2013-10-17
Release date:2014-03-12
Last modified:2014-04-23
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Structural polymorphism in the N-terminal oligomerization domain of NPM1.
Proc.Natl.Acad.Sci.USA, 111, 2014
<12>