Author results

2C86
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X-RAY STRUCTURE OF THE N AND C-TERMINAL DOMAIN OF CORONAVIRUS NUCLEOCAPSID PROTEIN.
Descriptor:NUCLEOCAPSID PROTEIN
Authors:Jayaram, H., Fan, H., Bowman, B.R., Ooi, A., Jayaram, J., Collinson, E.W., Lescar, J., Prasad, B.V.V.
Deposit date:2005-12-02
Release date:2006-06-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:X-Ray Structures of the N- and C-Terminal Domains of a Coronavirus Nucleocapsid Protein: Implications for Nucleocapsid Formation.
J.Virol., 80, 2006
2CA1
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CRYSTAL STRUCTURE OF THE IBV CORONAVIRUS NUCLEOCAPSID
Descriptor:NUCLEOCAPSID PROTEIN
Authors:Jayaram, H., Fan, H., Bowman, B.R., Ooi, A., Jayaram, J., Collison, E.W., Lescar, J., Prasad, B.V.V.
Deposit date:2005-12-16
Release date:2006-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:X-Ray Structures of the N- and C-Terminal Domains of a Coronavirus Nucleocapsid Protein: Implications for Nucleocapsid Formation.
J.Virol., 80, 2006
2GE7
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STRUCTURE OF THE C-TERMINAL DIMERIZATION DOMAIN OF INFECTIOUS BRONCHITIS VIRUS NUCLEOCAPSID PROTEIN
Descriptor:Nucleocapsid protein
Authors:Jayaram, H., Fan, H., Bowman, B.R., Ooi, A., Jayaram, J., Collisson, E.W., Lescar, J., Prasad, B.V.
Deposit date:2006-03-18
Release date:2006-06-27
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray structures of the N- and C-terminal domains of a coronavirus nucleocapsid protein: implications for nucleocapsid formation.
J.Virol., 80, 2006
2GE8
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STRUCTURE OF THE C-TERMINAL DIMERIZATION DOMAIN OF INFECTIOUS BRONCHITIS VIRUS NUCLEOCAPSID PROTEIN
Descriptor:Nucleocapsid protein
Authors:Jayaram, H., Fan, H., Bowman, B.R., Ooi, A., Jayaram, J., Collisson, E.W., Lescar, J., Prasad, B.V.
Deposit date:2006-03-18
Release date:2006-06-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:X-ray structures of the N- and C-terminal domains of a coronavirus nucleocapsid protein: implications for nucleocapsid formation.
J.Virol., 80, 2006
2GEC
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STRUCTURE OF THE N-TERMINAL DOMAIN OF AVIAN INFECTIOUS BRONCHITIS VIRUS NUCLEOCAPSID PROTEIN (STRAIN GRAY) IN A NOVEL DIMERIC ARRANGEMENT
Descriptor:Nucleocapsid protein
Authors:Jayaram, H., Fan, H., Bowman, B.R., Ooi, A., Jayaram, J., Collisson, E.W., Lescar, J., Prasad, B.V.
Deposit date:2006-03-19
Release date:2006-06-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:X-ray structures of the N- and C-terminal domains of a coronavirus nucleocapsid protein: implications for nucleocapsid formation.
J.Virol., 80, 2006
1L9V
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NON STRUCTURAL PROTEIN ENCODED BY GENE SEGMENT 8 OF ROTAVIRUS (NSP2), AN NTPASE, SSRNA BINDING AND NUCLEIC ACID HELIX-DESTABILIZING PROTEIN
Descriptor:Rotavirus-NSP2
Authors:Jayaram, H., Taraporewala, Z., Patton, J.T., Prasad, B.V.
Deposit date:2002-03-26
Release date:2002-06-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Rotavirus protein involved in genome replication and packaging exhibits a HIT-like fold.
Nature, 417, 2002
3DET
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STRUCTURE OF THE E148A, Y445A DOUBLY UNGATED MUTANT OF E.COLI CLC_EC1, CL-/H+ ANTIPORTER
Descriptor:H(+)/Cl(-) exchange transporter clcA, Fab fragment, Heavy chain, ...
Authors:Jayaram, H., Accardi, A., Wu, F., Williams, C., Miller, C.
Deposit date:2008-06-10
Release date:2008-06-17
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Ion permeation through a Cl--selective channel designed from a CLC Cl-/H+ exchanger
Proc.Natl.Acad.Sci.USA, 105, 2008
3ND0
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X-RAY CRYSTAL STRUCTURE OF A SLOW CYANOBACTERIAL CL-/H+ ANTIPORTER
Descriptor:Sll0855 protein, CHLORIDE ION
Authors:Jayaram, H., Robertson, J., Wu, F., Williams, C., Miller, C.
Deposit date:2010-06-06
Release date:2011-01-19
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of a Slow CLC Cl(-)/H(+) Antiporter from a Cyanobacterium.
Biochemistry, 50, 2011
3Q17
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STRUCTURE OF A SLOW CLC CL-/H+ ANTIPORTER FROM A CYANOBACTERIUM IN BROMIDE
Descriptor:Sll0855 protein, BROMIDE ION
Authors:Jayaram, H., Robertson, J.L., Fang, W., Williams, C., Miller, C.
Deposit date:2010-12-16
Release date:2011-01-19
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structure of a Slow CLC Cl(-)/H(+) Antiporter from a Cyanobacterium.
Biochemistry, 50, 2011
5JHN
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STRUCTURE OF G9A SET-DOMAIN WITH HISTONE H3K9ALA MUTANT PEPTIDE AND BOUND S-ADENOSYLMETHIONINE
Descriptor:Histone-lysine N-methyltransferase EHMT2, Histone H3.1 peptide with K9A mutation, ZINC ION, ...
Authors:Jayaram, H., Bellon, S.F., Poy, F.
Deposit date:2016-04-21
Release date:2016-07-06
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.
Proc.Natl.Acad.Sci.USA, 113, 2016
5JIN
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STRUCTURE OF G9A SET-DOMAIN WITH HISTONE H3K9M MUTANT PEPTIDE AND BOUND S-ADENOSYLMETHIONINE
Descriptor:Histone-lysine N-methyltransferase EHMT2, Histone H3.1 peptide with K9M mutation, ZINC ION, ...
Authors:Jayaram, H., Bellon, S.F., Poy, F.
Deposit date:2016-04-22
Release date:2016-07-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.
Proc.Natl.Acad.Sci.USA, 113, 2016
5JIY
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STRUCTURE OF G9A SET-DOMAIN WITH HISTONE H3K9NORLEUCINE MUTANT PEPTIDE AND BOUND S-ADENOSYLMETHIONINE
Descriptor:Histone-lysine N-methyltransferase EHMT2, Histone H3.1 mutant peptide with H3K9nor-leucine, ZINC ION, ...
Authors:Jayaram, H., Bellon, S.F., Poy, F.
Deposit date:2016-04-22
Release date:2016-09-14
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.
Proc.Natl.Acad.Sci.USA, 113, 2016
5JJ0
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STRUCTURE OF G9A SET-DOMAIN WITH HISTONE H3K9M PEPTIDE AND EXCESS SAH
Descriptor:Histone-lysine N-methyltransferase EHMT2, Histone H3K9M mutant peptide, ZINC ION, ...
Authors:Jayaram, H., Bellon, S.F., Poy, F.
Deposit date:2016-04-22
Release date:2016-07-06
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.
Proc.Natl.Acad.Sci.USA, 113, 2016
5I83
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN CREBBP BOUND TO THE BENZODIAZEPINONE G02773986
Descriptor:CREB-binding protein, THIOCYANATE ION, (4R)-4-methyl-7-[(1R)-1-phenylethoxy]-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one
Authors:Jayaram, H., Poy, F., Setser, J.W., Bellon, S.F.
Deposit date:2016-02-18
Release date:2016-04-20
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637).
Acs Med.Chem.Lett., 7, 2016
5I86
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN CREBBP BOUND TO THE BENZODIAZEPINONE G02778174
Descriptor:CREB-binding protein, 1,2-ETHANEDIOL, THIOCYANATE ION, ...
Authors:Jayaram, H., Poy, F., Setser, J.W., Bellon, S.F.
Deposit date:2016-02-18
Release date:2016-04-20
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637).
Acs Med.Chem.Lett., 7, 2016
4LR6
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STRUCTURE OF BRD4 BROMODOMAIN 1 WITH A 3-METHYL-4-PHENYLISOXAZOL-5-AMINE FRAGMENT
Descriptor:Bromodomain-containing protein 4, FORMIC ACID, 3-methyl-4-phenyl-1,2-oxazol-5-amine
Authors:Jayaram, H., Poy, F., Gehling, V., Hewitt, M., Vaswani, R., Leblanc, Y., Cote, A., Nasveschuk, C., Taylor, A., Harmange, J.-C., Audia, J., Pardo, E., Joshi, S., Sandy, P., Mertz, J., Sims, R., Bergeron, L., Bryant, B., Ravichandran, S., Yellapuntala, S., Nandana, B.S., Birudukota, S., Albrecht, B., Bellon, S.
Deposit date:2013-07-19
Release date:2013-08-07
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Discovery, Design, and Optimization of Isoxazole Azepine BET Inhibitors.
ACS Med Chem Lett, 4, 2013
5HLS
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 BOUND TO CPI-0610
Descriptor:Bromodomain-containing protein 4, CPI-0610
Authors:Jayaram, H., Poy, F., Setser, J.W., Bellon, S.F.
Deposit date:2016-01-15
Release date:2016-02-10
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (2.182 Å)
Cite:Identification of a Benzoisoxazoloazepine Inhibitor (CPI-0610) of the Bromodomain and Extra-Terminal (BET) Family as a Candidate for Human Clinical Trials.
J.Med.Chem., 59, 2016
5HM0
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 BOUND TO BENZOISOXAZOLOAZEPINE 3
Descriptor:Bromodomain-containing protein 4, 6-(4-chlorophenyl)-1-methyl-4H-[1,2]oxazolo[5,4-d][2]benzazepine
Authors:Jayaram, H., Poy, F., Setser, J.W., Bellon, S.F.
Deposit date:2016-01-15
Release date:2016-02-10
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (1.395 Å)
Cite:Identification of a Benzoisoxazoloazepine Inhibitor (CPI-0610) of the Bromodomain and Extra-Terminal (BET) Family as a Candidate for Human Clinical Trials.
J.Med.Chem., 59, 2016
5KTU
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN CREBBP BOUND TO PYRAZOLOPIPERIDINE SCAFFOLD
Descriptor:CREB-binding protein, 1-(3-phenylazanyl-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)ethanone, DIMETHYL SULFOXIDE
Authors:Jayaram, H., Poy, F., Setser, J.W., Bellon, S.F.
Deposit date:2016-07-12
Release date:2016-11-02
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.
J. Med. Chem., 59, 2016
2R7J
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CRYSTAL STRUCTURE OF ROTAVIRUS NON STRUCTURAL PROTEIN NSP2 WITH H225A MUTATION
Descriptor:Non-structural RNA-binding protein 35
Authors:Kumar, M., Jayaram, H., Prasad, B.V.V.
Deposit date:2007-09-09
Release date:2007-10-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystallographic and Biochemical Analysis of Rotavirus NSP2 with Nucleotides Reveals a Nucleoside Diphosphate Kinase-Like Activity
J.Virol., 81, 2007
2FEC
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STRUCTURE OF THE E203Q MUTANT OF THE CL-/H+ EXCHANGER CLC-EC1 FROM E.COLI
Descriptor:H(+)/Cl(-) exchange transporter clcA, Fab fragment, heavy chain, ...
Authors:Accardi, A., Walden, M.P., Nguitragool, W., Jayaram, H., Williams, C., Miller, C.
Deposit date:2005-12-15
Release date:2006-01-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.967 Å)
Cite:Separate ion pathways in a Cl-/H+ exchanger
J.Gen.Physiol., 126, 2005
2FED
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STRUCTURE OF THE E203Q MUTANT OF THE CL-/H+ EXCHANGER CLC-EC1 FROM E.COLI
Descriptor:H(+)/Cl(-) exchange transporter clcA, Fab fragment, heavy chain, ...
Authors:Accardi, A., Walden, M.P., Nguitragool, W., Jayaram, H., Williams, C., Miller, C.
Deposit date:2005-12-15
Release date:2006-01-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.317 Å)
Cite:Separate ion pathways in a Cl-/H+ exchanger
J.Gen.Physiol., 126, 2005
2FEE
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STRUCTURE OF THE CL-/H+ EXCHANGER CLC-EC1 FROM E.COLI IN NABR
Descriptor:H(+)/Cl(-) exchange transporter clcA, Fab fragment, heavy chain, ...
Authors:Accardi, A., Walden, M.P., Nguitragool, W., Jayaram, H., Williams, C., Miller, C.
Deposit date:2005-12-15
Release date:2006-01-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Separate ion pathways in a Cl-/H+ exchanger
J.Gen.Physiol., 126, 2005
3NCY
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X-RAY CRYSTAL STRUCTURE OF AN ARGININE AGMATINE ANTIPORTER (ADIC) IN COMPLEX WITH A FAB FRAGMENT
Descriptor:AdiC, Fab Heavy chain, Fab Light chain
Authors:Fang, Y., Jayaram, H., Shane, T., Komalkova-Partensky, L., Wu, F., Williams, C., Xiong, Y., Miller, C.
Deposit date:2010-06-06
Release date:2010-08-18
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of a prokaryotic virtual proton pump at 3.2 A resolution.
Nature, 460, 2009
4LRG
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STRUCTURE OF BRD4 BROMODOMAIN 1 WITH A DIMETHYL THIOPHENE ISOXAZOLE AZEPINE CARBOXAMIDE
Descriptor:Bromodomain-containing protein 4, 2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-[1,2]oxazolo[5,4-c]thieno[2,3-e]azepin-6-yl]acetamide
Authors:Ravichandran, S., Jayaram, H., Poy, F., Gehling, V., Hewitt, M., Vaswani, R., Leblanc, Y., Cote, A., Nasveschuk, C., Taylor, A., Harmange, J.-C., Audia, J., Pardo, E., Joshi, S., Sandy, P., Mertz, J., Sims, R., Bergeron, L., Bryant, B., Yellapuntala, S., Nandana, B.S., Birudukota, S., Albrecht, B., Bellon, S.
Deposit date:2013-07-19
Release date:2013-08-07
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Discovery, Design, and Optimization of Isoxazole Azepine BET Inhibitors.
ACS Med Chem Lett, 4, 2013
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