Structure of G9a SET-domain with Histone H3K9norLeucine mutant peptide and bound S-adenosylmethionine

Summary for 5JIY

Related5JIN 5JHN 5JJ0
DescriptorHistone-lysine N-methyltransferase EHMT2, Histone H3.1 mutant peptide with H3K9nor-leucine, ZINC ION, ... (5 entities in total)
Functional Keywordsset-domain, histone methyl transferase, histone peptide, transferase
Biological sourceHomo sapiens (Human)
Cellular locationNucleus  Q96KQ7
Total number of polymer chains4
Total molecular weight66886.45
Jayaram, H.,Bellon, S.F.,Poy, F. (deposition date: 2016-04-22, release date: 2016-09-14)
Primary citation
Jayaram, H.,Hoelper, D.,Jain, S.U.,Cantone, N.,Lundgren, S.M.,Poy, F.,Allis, C.D.,Cummings, R.,Bellon, S.,Lewis, P.W.
S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.
Proc.Natl.Acad.Sci.USA, 113:6182-6187, 2016
PubMed: 27185940 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1605523113
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.23810 1.0% 1.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-11-25