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5JJ0

Structure of G9a SET-domain with Histone H3K9M peptide and excess SAH

Summary for 5JJ0
Entry DOI10.2210/pdb5jj0/pdb
Related5JHN 5JIN 5JIY
DescriptorHistone-lysine N-methyltransferase EHMT2, Histone H3K9M mutant peptide, ZINC ION, ... (5 entities in total)
Functional Keywordsset-domain, histone methyl transferase, histone peptide, transferase
Biological sourceHomo sapiens (Human)
More
Cellular locationNucleus : Q96KQ7
Total number of polymer chains4
Total formula weight66922.52
Authors
Jayaram, H.,Bellon, S.F.,Poy, F. (deposition date: 2016-04-22, release date: 2016-07-06, Last modification date: 2023-09-27)
Primary citationJayaram, H.,Hoelper, D.,Jain, S.U.,Cantone, N.,Lundgren, S.M.,Poy, F.,Allis, C.D.,Cummings, R.,Bellon, S.,Lewis, P.W.
S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.
Proc.Natl.Acad.Sci.USA, 113:6182-6187, 2016
Cited by
PubMed: 27185940
DOI: 10.1073/pnas.1605523113
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.72 Å)
Structure validation

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