5JIY
Structure of G9a SET-domain with Histone H3K9norLeucine mutant peptide and bound S-adenosylmethionine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002039 | molecular_function | p53 binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016279 | molecular_function | protein-lysine N-methyltransferase activity |
| A | 0042054 | molecular_function | histone methyltransferase activity |
| B | 0002039 | molecular_function | p53 binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016279 | molecular_function | protein-lysine N-methyltransferase activity |
| B | 0042054 | molecular_function | histone methyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1201 |
| Chain | Residue |
| A | CYS974 |
| A | CYS987 |
| A | CYS1017 |
| A | CYS1021 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1202 |
| Chain | Residue |
| A | CYS974 |
| A | CYS976 |
| A | CYS980 |
| A | CYS985 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1203 |
| Chain | Residue |
| A | CYS1017 |
| A | CYS1023 |
| A | CYS1027 |
| A | CYS980 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1204 |
| Chain | Residue |
| A | CYS1115 |
| A | CYS1168 |
| A | CYS1170 |
| A | CYS1175 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | binding site for residue SAM A 1205 |
| Chain | Residue |
| A | MET1048 |
| A | TRP1050 |
| A | SER1084 |
| A | TYR1085 |
| A | ARG1109 |
| A | PHE1110 |
| A | ILE1111 |
| A | ASN1112 |
| A | HIS1113 |
| A | TYR1154 |
| A | PHE1158 |
| A | PHE1166 |
| A | THR1167 |
| A | CYS1168 |
| A | GLN1169 |
| F | NLE9 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1201 |
| Chain | Residue |
| B | CYS974 |
| B | CYS987 |
| B | CYS1017 |
| B | CYS1021 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1202 |
| Chain | Residue |
| B | CYS980 |
| B | CYS1017 |
| B | CYS1023 |
| B | CYS1027 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1203 |
| Chain | Residue |
| B | CYS974 |
| B | CYS976 |
| B | CYS980 |
| B | CYS985 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1204 |
| Chain | Residue |
| B | CYS1115 |
| B | CYS1168 |
| B | CYS1170 |
| B | CYS1175 |
| site_id | AD1 |
| Number of Residues | 13 |
| Details | binding site for residue SAM B 1205 |
| Chain | Residue |
| B | MET1048 |
| B | TRP1050 |
| B | SER1084 |
| B | TYR1085 |
| B | ARG1109 |
| B | PHE1110 |
| B | ASN1112 |
| B | HIS1113 |
| B | TYR1154 |
| B | PHE1166 |
| B | THR1167 |
| B | CYS1168 |
| B | GLN1169 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 126 |
| Details | Domain: {"description":"Pre-SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00157","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 117 |
| Details | Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | Domain: {"description":"Post-SET"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 25 |
| Details | Region: {"description":"Interaction with histone H3","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 36 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Site: {"description":"Histone H3K9me binding","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16267050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16457588","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"5-glutamyl serotonin; alternate","evidences":[{"source":"PubMed","id":"30867594","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by PKC","evidences":[{"source":"PubMed","id":"20228790","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Symmetric dimethylarginine; by PRMT5; alternate","evidences":[{"source":"UniProtKB","id":"P68433","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"11242053","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16185088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16267050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16457588","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by HASPIN and VRK1","evidences":[{"source":"PubMed","id":"15681610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16185088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31527692","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
