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3C0T
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STRUCTURE OF THE SCHIZOSACCHAROMYCES POMBE MEDIATOR SUBCOMPLEX MED8C/18
Descriptor:Mediator of RNA polymerase II transcription subunit 18, Mediator of RNA polymerase II transcription subunit 8
Authors:Lariviere, L., Seizl, M., van Wageningen, S., Roether, S., van de Pasch, L., Feldmann, H., Straesser, K., Hahn, S., Holstege, C.P., Cramer, P.
Deposit date:2008-01-21
Release date:2008-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure-system correlation identifies a gene regulatory Mediator submodule
Genes Dev., 22, 2008
6MZC
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HUMAN TFIID BC CORE
Descriptor:Transcription initiation factor TFIID subunit 2, Transcription initiation factor TFIID subunit 4, Transcription initiation factor TFIID subunit 5, ...
Authors:Patel, A.B., Louder, R.K., Greber, B.J., Grunberg, S., Luo, J., Fang, J., Liu, Y., Ranish, J., Hahn, S., Nogales, E.
Deposit date:2018-11-05
Release date:2018-11-28
Last modified:2019-01-02
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structure of human TFIID and mechanism of TBP loading onto promoter DNA.
Science, 362, 2018
6MZD
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HUMAN TFIID LOBE A CANONICAL
Descriptor:Transcription initiation factor TFIID subunit 1, Transcription initiation factor TFIID subunit 3, Transcription initiation factor TFIID subunit 4, ...
Authors:Patel, A.B., Louder, R.K., Greber, B.J., Grunberg, S., Luo, J., Fang, J., Liu, Y., Ranish, J., Hahn, S., Nogales, E.
Deposit date:2018-11-05
Release date:2018-11-28
Last modified:2019-01-02
Method:ELECTRON MICROSCOPY (9.8 Å)
Cite:Structure of human TFIID and mechanism of TBP loading onto promoter DNA.
Science, 362, 2018
6MZL
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HUMAN TFIID CANONICAL STATE
Descriptor:Transcription initiation factor TFIID subunit 1, Transcription initiation factor TFIID subunit 2, Transcription initiation factor TFIID subunit 3, ...
Authors:Patel, A.B., Louder, R.K., Greber, B.J., Grunberg, S., Luo, J., Fang, J., Liu, Y., Ranish, J., Hahn, S., Nogales, E.
Deposit date:2018-11-05
Release date:2018-11-28
Last modified:2019-01-02
Method:ELECTRON MICROSCOPY (23 Å)
Cite:Structure of human TFIID and mechanism of TBP loading onto promoter DNA.
Science, 362, 2018
6MZM
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HUMAN TFIID BOUND TO PROMOTER DNA AND TFIIA
Descriptor:Transcription initiation factor TFIID subunit 1, TAF1, Transcription initiation factor TFIID subunit 2, ...
Authors:Patel, A.B., Louder, R.K., Greber, B.J., Grunberg, S., Luo, J., Fang, J., Liu, Y., Ranish, J., Hahn, S., Nogales, E.
Deposit date:2018-11-05
Release date:2018-11-28
Last modified:2019-01-02
Method:ELECTRON MICROSCOPY (7.5 Å)
Cite:Structure of human TFIID and mechanism of TBP loading onto promoter DNA.
Science, 362, 2018
1YTB
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CRYSTAL STRUCTURE OF A YEAST TBP/TATA-BOX COMPLEX
Descriptor:DNA (29MER), PROTEIN (TATA BINDING PROTEIN (TBP))
Authors:Kim, Y., Geiger, J.H., Hahn, S., Sigler, P.B.
Deposit date:1994-09-28
Release date:1995-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of a yeast TBP/TATA-box complex.
Nature, 365, 1993
2LPB
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STRUCTURE OF THE COMPLEX OF THE CENTRAL ACTIVATION DOMAIN OF GCN4 BOUND TO THE MEDIATOR CO-ACTIVATOR DOMAIN 1 OF GAL11/MED15
Descriptor:Mediator of RNA polymerase II transcription subunit 15, General control protein GCN4
Authors:Brzovic, P.S., Heikaus, C.C., Kisselev, L., Vernon, R., Herbig, E., Pacheco, D., Warfield, L., Littlefield, P., Baker, D., Klevit, R.E., Hahn, S.
Deposit date:2012-02-07
Release date:2012-02-22
Method:SOLUTION NMR
Cite:The acidic transcription activator Gcn4 binds the mediator subunit Gal11/Med15 using a simple protein interface forming a fuzzy complex.
Mol.Cell, 44, 2011
6ALY
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SOLUTION STRUCTURE OF YEAST MED15 ABD2 RESIDUES 277-368
Descriptor:Mediator of RNA polymerase II transcription subunit 15
Authors:Tuttle, L.M., Pacheco, D., Warfield, L., Hahn, S., Klevit, R.E.
Deposit date:2017-08-08
Release date:2018-03-21
Last modified:2019-02-20
Method:SOLUTION NMR
Cite:Gcn4-Mediator Specificity Is Mediated by a Large and Dynamic Fuzzy Protein-Protein Complex.
Cell Rep, 22, 2018
4JV6
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THE CRYSTAL STRUCTURE OF PDE6D IN COMPLEX TO INHIBITOR-1
Descriptor:Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, 1-benzyl-2-phenyl-1H-benzimidazole
Authors:Gunther, Z., Papke, B., Ismail, S., Vartak, N., Chandra, A., Hoffmann, M., Hahn, S., Triola, G., Wittinghofer, A., Bastiaens, P., Waldmann, H.
Deposit date:2013-03-25
Release date:2013-05-22
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Small molecule inhibition of the KRAS PDEd interaction impairs oncogenic KRAS signalling
Nature, 497, 2013
4JV8
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THE CRYSTAL STRUCTURE OF PDE6D IN COMPLEX WITH RAC-S1
Descriptor:Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, (6R)-6-(pyridin-2-yl)-5,6-dihydrobenzimidazo[1,2-c]quinazoline
Authors:Gunther, Z., Papke, B., Ismail, S., Vartak, N., Chandra, A., Hoffmann, M., Hahn, S., Triola, G., Wittinghofer, A., Bastiaens, P., Waldmann, H.
Deposit date:2013-03-25
Release date:2013-05-22
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Small molecule inhibition of the KRAS PDEd interaction impairs oncogenic KRAS signalling
Nature, 497, 2013
4JVB
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CRYSTAL STRUCTURE OF PDE6D IN COMPLEX WITH THE INHIBITOR RAC-2
Descriptor:Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, 1-benzyl-2-(4-{[(2R)-2-(2-phenyl-1H-benzimidazol-1-yl)pent-4-en-1-yl]oxy}phenyl)-1H-benzimidazole
Authors:Gunther, Z., Papke, B., Ismail, S., Vartak, N., Chandra, A., Hoffmann, M., Hahn, S., Triola, G., Wittinghofer, A., Bastiaens, P., Waldmann, H.
Deposit date:2013-03-25
Release date:2013-05-22
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Small molecule inhibition of the KRAS PDEd interaction impairs oncogenic KRAS signalling
Nature, 497, 2013
4JVF
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THE CRYSTAL STRUCTURE OF PDE6D IN COMPLEX WITH THE INHIBITOR (S)-5
Descriptor:Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, (2S)-2-(2-phenyl-1H-benzimidazol-1-yl)-2-(piperidin-4-yl)ethyl 1-(1-benzyl-1H-benzimidazol-2-yl)piperidine-4-carboxylate
Authors:Gunther, Z., Papke, B., Ismail, S., Vartak, N., Chandra, A., Hoffmann, M., Hahn, S., Triola, G., Wittinghofer, A., Bastiaens, P., Waldmann, H.
Deposit date:2013-03-25
Release date:2013-05-22
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Small molecule inhibition of the KRAS PDEd interaction impairs oncogenic KRAS signalling
Nature, 497, 2013
3WQQ
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CRYSTAL STRUCTURE OF PFDXR COMPLEXED WITH INHIBITOR-3
Descriptor:1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Tanaka, N., Umeda, T.
Deposit date:2014-01-31
Release date:2014-11-26
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Binding Modes of Reverse Fosmidomycin Analogs toward the Antimalarial Target IspC.
J.Med.Chem., 57, 2014
3WQR
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CRYSTAL STRUCTURE OF PFDXR COMPLEXED WITH INHIBITOR-12
Descriptor:1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Tanaka, N., Umeda, T.
Deposit date:2014-01-31
Release date:2014-11-26
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Binding Modes of Reverse Fosmidomycin Analogs toward the Antimalarial Target IspC.
J.Med.Chem., 57, 2014
3WQS
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CRYSTAL STRUCTURE OF PFDXR COMPLEXED WITH INHIBITOR-126
Descriptor:1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Tanaka, N., Umeda, T.
Deposit date:2014-01-31
Release date:2014-11-26
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Binding Modes of Reverse Fosmidomycin Analogs toward the Antimalarial Target IspC.
J.Med.Chem., 57, 2014
1TFR
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RNASE H FROM BACTERIOPHAGE T4
Descriptor:T4 RNASE H, MAGNESIUM ION
Authors:Mueser, T.C., Nossal, N.G., Hyde, C.C.
Deposit date:1996-04-27
Release date:1996-11-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structure of bacteriophage T4 RNase H, a 5' to 3' RNA-DNA and DNA-DNA exonuclease with sequence similarity to the RAD2 family of eukaryotic proteins.
Cell(Cambridge,Mass.), 85, 1996
4KP7
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STRUCTURE OF PLASMODIUM ISPC IN COMPLEX WITH A BETA-THIA-ISOSTERE DERIVATIVE OF FOSMIDOMYCIN
Descriptor:1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast, MANGANESE (III) ION, ...
Authors:Kunfermann, A., Bacher, A., Groll, M.
Deposit date:2013-05-13
Release date:2013-10-02
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:IspC as Target for Antiinfective Drug Discovery: Synthesis, Enantiomeric Separation, and Structural Biology of Fosmidomycin Thia Isosters.
J.Med.Chem., 56, 2013