Author results

6NHX
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MYCOBACTERIAL DNA LIGASE D COMPLEXED WITH ATP AND MES
Descriptor:ATP-dependent DNA ligase, ADENOSINE-5'-TRIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Shuman, S., Unciuleac, M., Goldgur, Y.
Deposit date:2018-12-24
Release date:2019-02-13
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structures of ATP-bound DNA ligase D in a closed domain conformation reveal a network of amino acid and metal contacts to the ATP phosphates.
J. Biol. Chem., 2019
6NHZ
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MYCOBACTERIAL DNA LIGASE D COMPLEXED WITH ATP AND MG
Descriptor:ATP-dependent DNA ligase, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Shuman, S., Unciuleac, M., Goldgur, Y.
Deposit date:2018-12-24
Release date:2019-02-13
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of ATP-bound DNA ligase D in a closed domain conformation reveal a network of amino acid and metal contacts to the ATP phosphates.
J. Biol. Chem., 2019
6N0T
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TRNA LIGASE
Descriptor:tRNA ligase, SULFATE ION, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Banerjee, A., Goldgur, Y., Shuman, S.
Deposit date:2018-11-07
Release date:2019-01-09
Method:X-RAY DIFFRACTION (2.511 Å)
Cite:Structure and two-metal mechanism of fungal tRNA ligase.
Nucleic Acids Res., 2018
6N0V
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TRNA LIGASE
Descriptor:tRNA ligase, MANGANESE (II) ION
Authors:Banerjee, A., Goldgur, Y., Shuman, S.
Deposit date:2018-11-07
Release date:2019-01-09
Method:X-RAY DIFFRACTION (2.502 Å)
Cite:Structure and two-metal mechanism of fungal tRNA ligase.
Nucleic Acids Res., 2018
6E33
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CRYSTAL STRUCTURE OF PHO7-DNA COMPLEX
Descriptor:Uncharacterized transcriptional regulatory protein C27B12.11c, DNA (5'-D(*TP*CP*CP*TP*TP*CP*GP*GP*AP*CP*AP*TP*TP*CP*AP*AP*AP*TP*CP*A)-3'), DNA (5'-D(*GP*AP*TP*TP*TP*GP*AP*AP*TP*GP*TP*CP*CP*GP*AP*AP*GP*GP*AP*T)-3'), ...
Authors:Garg, A., Goldgur, Y., Shuman, S.
Deposit date:2018-07-13
Release date:2018-10-24
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (1.705 Å)
Cite:Distinctive structural basis for DNA recognition by the fission yeast Zn2Cys6 transcription factor Pho7 and its role in phosphate homeostasis.
Nucleic Acids Res., 46, 2018
6C33
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MYCOBACTERIUM SMEGMATIS DNA FLAP ENDONUCLEASE
Descriptor:5'-3' exonuclease, MANGANESE (II) ION
Authors:Shuman, S., Goldgur, Y., Carl, A., Uson, M.L.
Deposit date:2018-01-09
Release date:2018-03-28
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure and mutational analysis of Mycobacterium smegmatis FenA highlight active site amino acids and three metal ions essential for flap endonuclease and 5' exonuclease activities.
Nucleic Acids Res., 46, 2018
6C34
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MYCOBACTERIUM SMEGMATIS DNA FLAP ENDONUCLEASE MUTANT D125N
Descriptor:5'-3' exonuclease, MANGANESE (II) ION
Authors:Shuman, S., Goldgur, Y., Carl, A., Uson, M.L.
Deposit date:2018-01-09
Release date:2018-03-28
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure and mutational analysis of Mycobacterium smegmatis FenA highlight active site amino acids and three metal ions essential for flap endonuclease and 5' exonuclease activities.
Nucleic Acids Res., 46, 2018
6C35
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MYCOBACTERIUM SMEGMATIS FLAP ENDONUCLEASE MUTANT D148N
Descriptor:5'-3' exonuclease, MANGANESE (II) ION
Authors:Shuman, S., Goldgur, Y., Carl, A., Uson, M.L.
Deposit date:2018-01-09
Release date:2018-03-28
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.803 Å)
Cite:Crystal structure and mutational analysis of Mycobacterium smegmatis FenA highlight active site amino acids and three metal ions essential for flap endonuclease and 5' exonuclease activities.
Nucleic Acids Res., 46, 2018
6C36
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MYCOBACTERIUM SMEGMATIS FLAP ENDONUCLEASE MUTANT D208N
Descriptor:5'-3' exonuclease, MANGANESE (II) ION, PHOSPHATE ION
Authors:Shuman, S., Goldgur, Y., Carl, A., Uson, M.L.
Deposit date:2018-01-09
Release date:2018-03-28
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure and mutational analysis of Mycobacterium smegmatis FenA highlight active site amino acids and three metal ions essential for flap endonuclease and 5' exonuclease activities.
Nucleic Acids Res., 46, 2018
5U32
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CRYSTAL STRUCTURE OF FUNGAL RNA KINASE
Descriptor:tRNA ligase, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Shuman, S., Goldgur, Y., Remus, B.S.
Deposit date:2016-12-01
Release date:2017-11-15
Last modified:2017-12-27
Method:X-RAY DIFFRACTION (2.191 Å)
Cite:Structural basis for the GTP specificity of the RNA kinase domain of fungal tRNA ligase.
Nucleic Acids Res., 45, 2017
5TT5
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ESCHERICHIA COLI LIGA (K115M) IN COMPLEX WITH NAD+
Descriptor:DNA ligase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ZINC ION, ...
Authors:Goldgur, Y., Unciuleac, M.-C., Shuman, S.H.
Deposit date:2016-11-01
Release date:2017-03-08
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.552 Å)
Cite:Two-metal versus one-metal mechanisms of lysine adenylylation by ATP-dependent and NAD(+)-dependent polynucleotide ligases.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5TT6
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T4 RNA LIGASE 1 (K99M)
Descriptor:T4 RNA ligase 1, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:Goldgur, Y., Unciuleac, M.-C., Shuman, S.H.
Deposit date:2016-11-01
Release date:2017-03-08
Last modified:2017-03-22
Method:X-RAY DIFFRACTION (2.187 Å)
Cite:Two-metal versus one-metal mechanisms of lysine adenylylation by ATP-dependent and NAD(+)-dependent polynucleotide ligases.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5HFZ
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MMI1 YTH DOMAIN
Descriptor:YTH domain-containing protein mmi1
Authors:Chatterjee, D., Goldgur, Y., Shuman, S.
Deposit date:2016-01-07
Release date:2016-02-10
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Mmi1 YTH domain
To Be Published
5H8A
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MMI1 YTH DOMAIN
Descriptor:YTH domain-containing protein mmi1
Authors:Chatterjee, D., Goldgur, Y., Shuman, S.
Deposit date:2015-12-23
Release date:2016-01-13
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.751 Å)
Cite:Mmi1 YTH domain
To Be Published
5D8G
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A STRUCTURAL VIEW ON THE DISSOCIATION OF E. COLI TRYPTOPHANASE
Descriptor:Tryptophanase, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Almog, O.
Deposit date:2015-08-17
Release date:2015-12-09
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:A structural view of the dissociation of Escherichia coli tryptophanase.
Acta Crystallogr.,Sect.D, 71, 2015
5COT
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STRUCTURE AND MECHANISM OF A EUKARYAL NICK-SEALING RNA LIGASE
Descriptor:Naegleria gruberi RNA ligase, ADENOSINE MONOPHOSPHATE, UNKNOWN ATOM OR ION
Authors:Unciuleac, M.C., Goldgur, Y., Shuman, S.
Deposit date:2015-07-20
Release date:2015-10-28
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Structure and two-metal mechanism of a eukaryal nick-sealing RNA ligase.
Proc.Natl.Acad.Sci.USA, 112, 2015
5COU
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STRUCTURE AND MECHANISM OF A EUKARYAL NICK-SEALING RNA LIGASE K170M+ATP
Descriptor:Naegleria gruberi RNA ligase, ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION
Authors:Unciuleac, M.C., Goldgur, Y., Shuman, S.
Deposit date:2015-07-20
Release date:2015-10-28
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure and two-metal mechanism of a eukaryal nick-sealing RNA ligase.
Proc.Natl.Acad.Sci.USA, 112, 2015
5COV
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STRUCTURE AND MECHANISM OF A EUKARYAL NICK-SEALING RNA LIGASE K170M+MN
Descriptor:Naegleria gruberi RNA ligase, MANGANESE (II) ION
Authors:Unciuleac, M.C., Goldgur, Y., Shuman, S.
Deposit date:2015-07-20
Release date:2015-10-28
Last modified:2015-11-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and two-metal mechanism of a eukaryal nick-sealing RNA ligase.
Proc.Natl.Acad.Sci.USA, 112, 2015
5CMA
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ANTI-B7-H3 MONOCLONAL ANTIBODY CH8H9 FAB FRAGMENT
Descriptor:Antibody ch8H9 Fab light chain, Antibody ch8H9 Fab heavy chain
Authors:Ahmed, M., Goldgur, Y., Cheng, M., Cheung, N.K.
Deposit date:2015-07-16
Release date:2015-10-28
Last modified:2015-12-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Humanized Affinity-matured Monoclonal Antibody 8H9 Has Potent Antitumor Activity and Binds to FG Loop of Tumor Antigen B7-H3.
J.Biol.Chem., 290, 2015
4W4H
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ESCHERICHIA COLI TRYPTOPHANASE IN HOLO FORM
Descriptor:Tryptophanase
Authors:Goldgur, Y.
Deposit date:2014-08-14
Release date:2014-12-17
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Structures of Escherichia coli tryptophanase in holo and `semi-holo' forms.
Acta Crystallogr.,Sect.F, 71, 2015
4W1Y
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI TRYPTOPHANASE IN 'SEMI-HOLO' FORM
Descriptor:Tryptophanase, SULFATE ION
Authors:Goldgur, Y.
Deposit date:2014-08-13
Release date:2014-12-17
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structures of Escherichia coli tryptophanase in holo and `semi-holo' forms.
Acta Crystallogr.,Sect.F, 71, 2015
4P8S
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CRYSTAL STRUCTURE OF NOGO-RECEPTOR-2
Descriptor:Reticulon-4 receptor-like 2, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE
Authors:Semavina, M., Saha, N., Kolev, M.V., Giger, R.J., Himanen, J.P., Nikolov, D.B.
Deposit date:2014-04-01
Release date:2014-04-09
Last modified:2015-02-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the Nogo-receptor-2.
Protein Sci., 2011
4P91
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CRYSTAL STRUCTURE OF THE NOGO-RECEPTOR-2 (27-330)
Descriptor:Reticulon-4 receptor-like 2, N-ACETYL-D-GLUCOSAMINE
Authors:Semavina, M., Saha, N., Kolev, M., Goldgur, Y., Giger, R., Himanen, J., Nikolov, D.
Deposit date:2014-04-01
Release date:2014-04-30
Last modified:2015-02-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the Nogo-receptor-2.
Protein Sci., 20, 2011
4M4P
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CRYSTAL STRUCTURE OF EPHA4 ECTODOMAIN
Descriptor:Ephrin type-A receptor 4, N-ACETYL-D-GLUCOSAMINE
Authors:Xu, K., Tsvetkova-Robev, D., Xu, Y., Goldgur, Y., Chan, Y.-P., Himanen, J.P., Nikolov, D.B.
Deposit date:2013-08-07
Release date:2013-10-30
Method:X-RAY DIFFRACTION (2.081 Å)
Cite:Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5.
Proc.Natl.Acad.Sci.USA, 110, 2013
4M4R
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EPHA4 ECTODOMAIN COMPLEX WITH EPHRIN A5
Descriptor:Ephrin type-A receptor 4, Ephrin-A5, N-ACETYL-D-GLUCOSAMINE
Authors:Xu, K., Tsvetkova-Robev, D., Xu, Y., Goldgur, Y., Chan, Y.-P., Himanen, J.P., Nikolov, D.B.
Deposit date:2013-08-07
Release date:2013-10-30
Method:X-RAY DIFFRACTION (3.13 Å)
Cite:Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5.
Proc.Natl.Acad.Sci.USA, 110, 2013
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