8F8W

Crystal structure of Nb.X0 bound to the afucosylated human IgG1 fragment crystal form I

Summary for 8F8W

Entry DOI	10.2210/pdb8f8w/pdb
Descriptor	afucosylated IgG1 fragment, Nb.X0, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	nanobody, glycobiology, immunoglobulin, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	8
Total formula weight	159122.01
Authors	Goldgur, Y.,Ravetch, J.,Gupta, A.,Kao, K.,Oren, D. (deposition date: 2022-11-22, release date: 2023-03-29, Last modification date: 2023-10-11)
Primary citation	Gupta, A.,Kao, K.S.,Yamin, R.,Oren, D.A.,Goldgur, Y.,Du, J.,Lollar, P.,Sundberg, E.J.,Ravetch, J.V. Mechanism of glycoform specificity and in vivo protection by an anti-afucosylated IgG nanobody. Nat Commun, 14:2853-2853, 2023 Cited by PubMed: 37202422 DOI: 10.1038/s41467-023-38453-1 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.71 Å)

Structure validation