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1VYQ
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NOVEL INHIBITORS OF PLASMODIUM FALCIPARUM DUTPASE PROVIDE A PLATFORM FOR ANTI-MALARIAL DRUG DESIGN
Descriptor:DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE, 2,3-DEOXY-3-FLUORO-5-O-TRITYLURIDINE
Authors:Whittingham, J.L., Leal, I., Kasinathan, G., Nguyen, C., Bell, E., Jones, A.F., Berry, C., Benito, A., Turkenburg, J.P., Dodson, E.J., Ruiz Perez, L.M., Wilkinson, A.J., Johansson, N.G., Brun, R., Gilbert, I.H., Gonzalez Pacanowska, D., Wilson, K.S.
Deposit date:2004-05-05
Release date:2005-05-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Dutpase as a Platform for Antimalarial Drug Design: Structural Basis for the Selectivity of a Class of Nucleoside Inhibitors.
Structure, 13, 2005
2WWF
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PLASMODIUM FALCIPARUM THYMIDYLATE KINASE IN COMPLEX WITH TMP AND ADP
Descriptor:THYMIDILATE KINASE, PUTATIVE, THYMIDINE-5'-PHOSPHATE, ...
Authors:Whittingham, J.L., Carrero-Lerida, J., Brannigan, J.A., Ruiz-Perez, L.M., Silva, A.P.G., Fogg, M.J., Wilkinson, A.J., Gilbert, I.H., Wilson, K.S., Gonzalez-Pacanowska, D.
Deposit date:2009-10-23
Release date:2010-04-21
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structural Basis for the Efficient Phosphorylation of Aztmp and Dgmp by Plasmodium Falciparum Type I Thymidylate Kinase.
Biochem.J., 428, 2010
2WWG
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PLASMODIUM FALCIPARUM THYMIDYLATE KINASE IN COMPLEX WITH DGMP AND ADP
Descriptor:THYMIDILATE KINASE, PUTATIVE, 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, ...
Authors:Whittingham, J.L., Carrero-Lerida, J., Brannigan, J.A., Ruiz-Perez, L.M., Silva, A.P., Fogg, M.J., Wilkinson, A.J., Gilbert, I.H., Wilson, K.S., Gonzalez-Pacanowska, D.
Deposit date:2009-10-23
Release date:2010-04-21
Last modified:2013-03-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis for the Efficient Phosphorylation of Aztmp and Dgmp by Plasmodium Falciparum Type I Thymidylate Kinase.
Biochem.J., 428, 2010
2WWH
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PLASMODIUM FALCIPARUM THYMIDYLATE KINASE IN COMPLEX WITH AP5DT
Descriptor:THYMIDILATE KINASE, PUTATIVE, P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE, ...
Authors:Whittingham, J.L., Carrero-Lerida, J., Brannigan, J.A., Ruiz-Perez, L.M., Silva, A.P.G., Fogg, M.J., Wilkinson, A.J., Gilbert, I.H., Wilson, K.S., Gonzalez-Pacanowska, D.
Deposit date:2009-10-23
Release date:2010-04-21
Last modified:2016-12-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Basis for the Efficient Phosphorylation of Aztmp and Dgmp by Plasmodium Falciparum Type I Thymidylate Kinase.
Biochem.J., 428, 2010
2WWI
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PLASMODIUM FALCIPARUM THYMIDYLATE KINASE IN COMPLEX WITH AZTMP AND ADP
Descriptor:THYMIDILATE KINASE, PUTATIVE, 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ...
Authors:Whittingham, J.L., Carrero-Lerida, J., Brannigan, J.A., Ruiz-Perez, L.M., Silva, A.P.G., Fogg, M.J., Wilkinson, A.J., Gilbert, I.H., Wilson, K.S., Gonzalez-Pacanowska, D.
Deposit date:2009-10-23
Release date:2010-04-21
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Structural Basis for the Efficient Phosphorylation of Aztmp and Dgmp by Plasmodium Falciparum Type I Thymidylate Kinase.
Biochem.J., 428, 2010
2Y8C
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PLASMODIUM FALCIPARUM DUTPASE IN COMPLEX WITH A TRITYL LIGAND
Descriptor:DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE, (2S)-2-[(2,4-dioxopyrimidin-1-yl)methyl]-N-(2-hydroxyethyl)-4-trityloxy-butanamide, SULFATE ION
Authors:Baragana, B., McCarthy, O., Sanchez, P., Bosch, C., Kaiser, M., Brun, R., Whittingham, J.L., Roberts, S., Zhou, X.-X., Wilson, K.S., Johansson, N.G., Gonzalez-Pacanowska, D., Gilbert, I.H.
Deposit date:2011-02-04
Release date:2012-03-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Beta-Branched Acyclic Nucleoside Analogues as Inhibitors of Plasmodium Falciparum Dutpase
Bioorg.Med.Chem., 19, 2011
2YOF
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PLASMODIUM FALCIPARUM THYMIDYLATE KINASE IN COMPLEX WITH A (THIO)UREA- BETA-DEOXYTHYMIDINE INHIBITOR
Descriptor:THYMIDYLATE KINASE, 1-[4-chloranyl-3-(trifluoromethyl)phenyl]-3-[[(2R,3S)-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-oxidanyl-oxolan-2-yl]methyl]thiourea, ACETATE ION, ...
Authors:Huaqing, C., Carrero-Lerida, J., Silva, A.P.G., Whittingham, J.L., Brannigan, J.A., Ruiz-Perez, L.M., Read, K.D., Wilson, K.S., Gonzalez-Pacanowska, D., Gilbert, I.H.
Deposit date:2012-10-24
Release date:2013-07-24
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Synthesis and Evaluation of Alpha-Thymidine Analogues as Novel Antimalarials.
J.Med.Chem., 55, 2012
2YOG
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PLASMODIUM FALCIPARUM THYMIDYLATE KINASE IN COMPLEX WITH A (THIO)UREA- ALPHA-DEOXYTHYMIDINE INHIBITOR
Descriptor:THYMIDYLATE KINASE, 1-[4-chloranyl-3-(trifluoromethyl)phenyl]-3-[[(2R,3S)-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-oxidanyl-oxolan-2-yl]methyl]thiourea
Authors:Huaqing, C., Carrero-Lerida, J., Silva, A.P.G., Whittingham, J.L., Brannigan, J.A., Ruiz-Perez, L.M., Read, K.D., Wilson, K.S., Gonzalez-Pacanowska, D., Gilbert, I.H.
Deposit date:2012-10-24
Release date:2013-07-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Synthesis and Evaluation of Alpha-Thymidine Analogues as Novel Antimalarials.
J.Med.Chem., 55, 2012
2YOH
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PLASMODIUM FALCIPARUM THYMIDYLATE KINASE IN COMPLEX WITH A UREA-ALPHA- DEOXYTHYMIDINE INHIBITOR
Descriptor:THYMIDYLATE KINASE, 1-[[(2R,3S,5S)-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-oxidanyl-oxolan-2-yl]methyl]-3-(4-nitrophenyl)urea
Authors:Huaqing, C., Carrero-Lerida, J., Silva, A.P.G., Whittingham, J.L., Brannigan, J.A., Ruiz-Perez, L.M., Read, K.D., Wilson, K.S., Gonzalez-Pacanowska, D., Gilbert, I.H.
Deposit date:2012-10-24
Release date:2013-07-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Synthesis and Evaluation of Alpha-Thymidine Analogues as Novel Antimalarials.
J.Med.Chem., 55, 2012
3T60
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5'-DIPHENYL NUCLEOSIDE INHIBITORS OF PLASMODIUM FALCIPARUM DUTPASE
Descriptor:Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative, 2',5'-dideoxy-5'-(tritylamino)uridine, ...
Authors:Hampton, S.E., Baragana, B., Schipani, A., Bosch-Navarrete, C., Musso-Buendia, A., Recio, E., Kaiser, M., Whittingham, J.L., Roberts, S.M., Shevtsov, M., Brannigan, J.A., Kahnberg, P., Brun, R., Wilson, K.S., Gonzalez-Pacanowska, D., Johansson, N.G., Gilbert, I.H.
Deposit date:2011-07-28
Release date:2012-08-29
Method:X-RAY DIFFRACTION (2.396 Å)
Cite:Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase.
Chemmedchem, 6, 2011
3T64
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5'-DIPHENYL NUCLEOSIDE INHIBITORS OF PLASMODIUM FALCIPARUM DUTPASE
Descriptor:Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative, 5'-(BENZHYDRYLAMINO)-2',5'-DIDEOXYURIDINE, ...
Authors:Hampton, S.E., Baragana, B., Schipani, A., Bosch-Navarrete, C., Musso-Buendia, A., Recio, E., Kaiser, M., Whittingham, J.L., Roberts, S.M., Shevtsov, M., Brannigan, J.A., Kahnberg, P., Brun, R., Wilson, K.S., Gonzalez-Pacanowska, D., Johansson, N.G., Gilbert, I.H.
Deposit date:2011-07-28
Release date:2012-08-29
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase.
Chemmedchem, 6, 2011
3T6Y
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5'-DIPHENYL NUCLEOSIDE INHIBITORS OF PLASMODIUM FALCIPARUM DUTPASE
Descriptor:Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative, peptide ALA-HIS-ALA, ...
Authors:Hampton, S.E., Baragana, B., Schipani, A., Bosch-Navarrete, C., Musso-Buendia, A., Recio, E., Kaiser, M., Whittingham, J.L., Roberts, S.M., Shevtsov, M., Brannigan, J.A., Kahnberg, P., Brun, R., Wilson, K.S., Gonzalez-Pacanowska, D., Johansson, N.G., Gilbert, I.H.
Deposit date:2011-07-29
Release date:2012-08-29
Last modified:2019-10-09
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase.
Chemmedchem, 6, 2011
3T70
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5'-DIPHENYL NUCLEOSIDE INHIBITORS OF PLASMODIUM FALCIPARUM DUTPASE
Descriptor:Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative, PEPTIDE GLY-HIS-GLY, ...
Authors:Hampton, S.E., Baragana, B., Schipani, A., Bosch-Navarrete, C., Musso-Buendia, A., Recio, E., Kaiser, M., Whittingham, J.L., Roberts, S.M., Shevtsov, M., Brannigan, J.A., Kahnberg, P., Brun, R., Wilson, K.S., Gonzalez-Pacanowska, D., Johansson, N.G., Gilbert, I.H.
Deposit date:2011-07-29
Release date:2012-08-29
Last modified:2019-10-09
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase.
Chemmedchem, 6, 2011
4A31
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CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND
Descriptor:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, GLYCEROL, 6-{[2-(4-METHYLPIPERAZIN-1-YL)ETHYL]AMINO}-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)PYRIDINE-3-SULFONAMIDE, ...
Authors:Robinson, D.A., Brand, S., Cleghorn, L.A.T., McElroy, S.P., Smith, V.C., Hallyburton, I., Harrison, J.R., Norcross, N.R., Norval, S., Spinks, D., Stojanovski, L., Torrie, L.S., Frearson, J.A., Brenk, R., Fairlamb, A.H., Ferguson, M.A.J., Read, K.D., Wyatt, P.G., Gilbert, I.H.
Deposit date:2011-09-29
Release date:2011-12-21
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.
J. Med. Chem., 55, 2012
4A32
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CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND
Descriptor:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, GLYCEROL, 3,5-DICHLORO-3'-[(DIETHYLAMINO)METHYL]-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BIPHENYL-4-SULFONAMIDE, ...
Authors:Robinson, D.A., Brand, S., Cleghorn, L.A.T., McElroy, S.P., Smith, V.C., Hallyburton, I., Harrison, J.R., Norcross, N.R., Norval, S., Spinks, D., Stojanovski, L., Torrie, L.S., Frearson, J.A., Brenk, R., Fairlamb, A.H., Ferguson, M.A.J., Read, K.D., Wyatt, P.G., Gilbert, I.H.
Deposit date:2011-09-29
Release date:2011-12-21
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.
J. Med. Chem., 55, 2012
4A33
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CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND
Descriptor:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, 2,6-DICHLORO-4-(6-PIPERAZIN-1-YLPYRIDIN-3-YL)-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE, TETRADECANOYL-COA
Authors:Robinson, D.A., Brand, S., Cleghorn, L.A.T., McElroy, S.P., Smith, V.C., Hallyburton, I., Harrison, J.R., Norcross, N.R., Norval, S., Spinks, D., Stojanovski, L., Torrie, L.S., Frearson, J.A., Brenk, R., Fairlamb, A.H., Ferguson, M.A.J., Read, K.D., Wyatt, P.G., Gilbert, I.H.
Deposit date:2011-09-29
Release date:2011-12-21
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.
J. Med. Chem., 55, 2012
4CAV
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CRYSTAL STRUCTURE OF ASPERGILLUS FUMIGATUS N-MYRISTOYL TRANSFERASE IN COMPLEX WITH MYRISTOYL COA AND A BENZOFURAN LIGAND R0-09-4879
Descriptor:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, CHLORIDE ION, 3-[[3-methyl-2-[[2,3,4-tris(fluoranyl)phenoxy]methyl]-1-benzofuran-4-yl]oxy]-N-(pyridin-3-ylmethyl)propan-1-amine, ...
Authors:Robinson, D.A., Fang, W., Raimi, O.G., Blair, D.E., Harrison, J., Ruda, G.F., Lockhart, D.E.A., Torrie, L.S., Wyatt, P.G., Gilbert, I.H., Van Aalten, D.M.F.
Deposit date:2013-10-09
Release date:2014-09-17
Last modified:2016-03-23
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:N-Myristoyltransferase is a Cell Wall Target in Aspergillus Fumigatus.
Acs Chem.Biol., 10, 2015
4CAW
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CRYSTAL STRUCTURE OF ASPERGILLUS FUMIGATUS N-MYRISTOYL TRANSFERASE IN COMPLEX WITH MYRISTOYL COA AND A PYRAZOLE SULPHONAMIDE LIGAND
Descriptor:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, 2,6-DICHLORO-4-(2-PIPERAZIN-1-YLPYRIDIN-4-YL)-N-(1,5-DIMETHYL,3-ISOBUTYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE, TETRADECANOYL-COA
Authors:Robinson, D.A., Fang, W., Raimi, O.G., Blair, D.E., Harrison, J., Ruda, G.F., Lockhart, D.E.A., Torrie, L.S., Wyatt, P.G., Gilbert, I.H., Van Aalten, D.M.F.
Deposit date:2013-10-09
Release date:2014-09-17
Last modified:2016-03-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:N-Myristoyltransferase is a Cell Wall Target in Aspergillus Fumigatus.
Acs Chem.Biol., 10, 2015
4CAX
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CRYSTAL STRUCTURE OF ASPERGILLUS FUMIGATUS N-MYRISTOYL TRANSFERASE IN COMPLEX WITH MYRISTOYL COA AND A PYRAZOLE SULPHONAMIDE LIGAND (DDD85646)
Descriptor:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, TETRADECANOYL-COA, 2,6-dichloro-4-(2-piperazin-1-ylpyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
Authors:Raimi, O.G., Robinson, D.A., Fang, W., Blair, D.E., Harrison, J., Ruda, G.F., Lockhart, D.E.A., Torrie, L.S., Wyatt, P.G., Gilbert, I.H., Van Aalten, D.M.F.
Deposit date:2013-10-09
Release date:2014-09-17
Last modified:2016-03-23
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:N-Myristoyltransferase is a Cell Wall Target in Aspergillus Fumigatus.
Acs Chem.Biol., 10, 2015
4EFC
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CRYSTAL STRUCTURE OF ADENYLOSUCCINATE LYASE FROM TRYPANOSOMA BRUCEI, TB427TMP.160.5560
Descriptor:Adenylosuccinate lyase, ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, ...
Authors:Wernimont, A.K., Loppnau, P., Osman, K.T., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Robinson, D.A., Wyatt, P.G., Gilbert, I.H., Fairlamb, A.H., Hui, R., Lin, Y.H., Structural Genomics Consortium (SGC)
Deposit date:2012-03-29
Release date:2013-02-13
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Adenylosuccinate Lyase from Trypanosoma Brucei, Tb427tmp.160.5560
To be Published
4UWI
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CRYSTAL STRUCTURE OF ASPERGILLUS FUMIGATUS N-MYRISTOYL TRANSFERASE IN COMPLEX WITH MYRISTOYL COA AND A PYRAZOLE SULPHONAMIDE LIGAND
Descriptor:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, 2,6-dichloro-4-[3-(4-methylpiperazin-1-yl)propyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide, TETRADECANOYL-COA
Authors:Robinson, D.A., Brand, S., Norcross, N.R., Thompson, S., Harrison, J.R., Smith, V.C., Torrie, L.S., McElroy, S.P., Hallyburton, I., Norval, S., Stojanovski, L., Simeons, F.R.C., Frearson, J.A., Brenk, R., Fairlamb, A.H., Ferguson, M.A.J., Wyatt, P.G., Gilbert, I.H., Read, K.D.
Deposit date:2014-08-12
Release date:2014-12-03
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Lead optimization of a pyrazole sulfonamide series of Trypanosoma brucei N-myristoyltransferase inhibitors: identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human African trypanosomiasis.
J. Med. Chem., 57, 2014
4UWJ
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CRYSTAL STRUCTURE OF ASPERGILLUS FUMIGATUS N-MYRISTOYL TRANSFERASE IN COMPLEX WITH MYRISTOYL COA AND A CAPPED PYRAZOLE SULPHONAMIDE LIGAND
Descriptor:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, 2,6-dichloro-N-(difluoromethyl)-4-[3-(piperidin-4-yl)propyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide, TETRADECANOYL-COA
Authors:Robinson, D.A., Brand, S., Norcross, N.R., Thompson, S., Harrison, J.R., Smith, V.C., Torrie, L.S., McElroy, S.P., Hallyburton, I., Norval, S., Stojanovski, L., Simeons, F.R.C., Frearson, J.A., Brenk, R., Fairlamb, A.H., Ferguson, M.A.J., Wyatt, P.G., Gilbert, I.H., Read, K.D.
Deposit date:2014-08-12
Release date:2014-12-03
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Lead optimization of a pyrazole sulfonamide series of Trypanosoma brucei N-myristoyltransferase inhibitors: identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human African trypanosomiasis.
J. Med. Chem., 57, 2014
5AG4
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CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A THIAZOLIDINONE LIGAND
Descriptor:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, TETRADECANOYL-COA, (2S)-3-(3-chlorophenyl)-2-(pyridin-2-yl)-1,3-thiazolidin-4-one
Authors:Robinson, D.A., Spinks, D., Smith, V.C., Thompson, S., Smith, A., Torrie, L.S., McElroy, S.P., Brand, S., Brenk, R., Frearson, J.A., Read, K.D., Wyatt, P.G., Gilbert, I.H.
Deposit date:2015-01-29
Release date:2015-10-07
Last modified:2015-11-11
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Development of Small-Molecule Trypanosoma Brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode.
Chemmedchem, 10, 2015
5AG5
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CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A THIAZOLIDINONE LIGAND
Descriptor:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, (2R)-3-benzyl-2-(1H-indazol-5-yl)-1,3-thiazolidin-4-one, TETRADECANOYL-COA
Authors:Robinson, D.A., Spinks, D., Smith, V.C., Thompson, S., Smith, A., Torrie, L.S., McElroy, S.P., Brand, S., Brenk, R., Frearson, J.A., Read, K.D., Wyatt, P.G., Gilbert, I.H.
Deposit date:2015-01-29
Release date:2015-10-07
Last modified:2015-11-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Development of Small-Molecule Trypanosoma Brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode.
Chemmedchem, 10, 2015
5AG6
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CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A THIAZOLIDINONE LIGAND
Descriptor:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, (2R)-2-(4-hydroxy-3-methoxyphenyl)-3-(pyridin-2-ylmethyl)-1,3-thiazolidin-4-one, TETRADECANOYL-COA
Authors:Robinson, D.A., Spinks, D., Smith, V.C., Thompson, S., Smith, A., Torrie, L.S., McElroy, S.P., Brand, S., Brenk, R., Frearson, J.A., Read, K.D., Wyatt, P.G., Gilbert, I.H.
Deposit date:2015-01-29
Release date:2015-10-07
Last modified:2015-11-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Development of Small-Molecule Trypanosoma Brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode.
Chemmedchem, 10, 2015
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