5AG6

CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A THIAZOLIDINONE LIGAND

Summary for 5AG6

• Entry DOI: 10.2210/pdb5ag6/pdb
• Related: 5AG4 5AG5 5AG7 5AGE
• Descriptor: GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, (2R)-2-(4-hydroxy-3-methoxyphenyl)-3-(pyridin-2-ylmethyl)-1,3-thiazolidin-4-one, TETRADECANOYL-COA, ... (4 entities in total)
• Functional Keywords: n-myristoyltransferase, nmt, acyltransferase, transferase, drug discovery
• Biological source: LEISHMANIA MAJOR
• Total number of polymer chains: 1
• Total formula weight: 51807.52

Authors

Robinson, D.A.,Spinks, D.,Smith, V.C.,Thompson, S.,Smith, A.,Torrie, L.S.,McElroy, S.P.,Brand, S.,Brenk, R.,Frearson, J.A.,Read, K.D.,Wyatt, P.G.,Gilbert, I.H. (deposition date: 2015-01-29, release date: 2015-10-07, Last modification date: 2024-01-10)

• Primary citation: Spinks, D.,Smith, V.,Thompson, S.,Robinson, D.A.,Luksch, T.,Smith, A.,Torrie, L.S.,Mcelroy, S.,Stojanovski, L.,Norval, S.,Collie, I.T.,Hallyburton, I.,Rao, B.,Brand, S.,Brenk, R.,Frearson, J.A.,Read, K.D.,Wyatt, P.G.,Gilbert, I.H.; Development of Small-Molecule Trypanosoma Brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode.; Chemmedchem, 10:1821-, 2015; PubMed: 26395087; DOI: 10.1002/CMDC.201500301

Experimental method

X-RAY DIFFRACTION (2 Å)