Author results

1FW2
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OUTER MEMBRANE PHOSPHOLIPASE A FROM ESCHERICHIA COLI
Descriptor:OUTER MEMBRANE PHOSPHOLIPASE A, CALCIUM ION
Authors:Snijder, H.J., Kingma, R.L., Kalk, K.H., Dekker, N., Egmond, M.R., Dijkstra, B.W.
Deposit date:2000-09-21
Release date:2001-06-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural investigations of calcium binding and its role in activity and activation of outer membrane phospholipase A from Escherichia coli.
J.Mol.Biol., 309, 2001
1FW3
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OUTER MEMBRANE PHOSPHOLIPASE A FROM ESCHERICHIA COLI
Descriptor:OUTER MEMBRANE PHOSPHOLIPASE A
Authors:Snijder, H.J., Kingma, R.L., Kalk, K.H., Dekker, N., Egmond, M.R., Dijkstra, B.W.
Deposit date:2000-09-21
Release date:2001-06-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural investigations of calcium binding and its role in activity and activation of outer membrane phospholipase A from Escherichia coli.
J.Mol.Biol., 309, 2001
1ILD
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OUTER MEMBRANE PHOSPHOLIPASE A FROM ESCHERICHIA COLI N156A ACTIVE SITE MUTANT PH 4.6
Descriptor:OUTER MEMBRANE PHOSPHOLIPASE A, B-OCTYLGLUCOSIDE, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Snijder, H.J., Van Eerde, J.H., Kingma, R.L., Kalk, K.H., Dekker, N., Egmond, M.R., Dijkstra, B.W.
Deposit date:2001-05-08
Release date:2001-10-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural investigations of the active-site mutant Asn156Ala of outer membrane phospholipase A: function of the Asn-His interaction in the catalytic triad.
Protein Sci., 10, 2001
1ILZ
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OUTER MEMBRANE PHOSPHOLIPASE A FROM ESCHERICHIA COLI N156A ACTIVE SITE MUTANT PH 6.1
Descriptor:OUTER MEMBRANE PHOSPHOLIPASE A, B-OCTYLGLUCOSIDE, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Snijder, H.J., Van Eerde, J.H., Kingma, R.L., Kalk, K.H., Dekker, N., Egmond, M.R., Dijkstra, B.W.
Deposit date:2001-05-09
Release date:2001-10-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural investigations of the active-site mutant Asn156Ala of outer membrane phospholipase A: function of the Asn-His interaction in the catalytic triad.
Protein Sci., 10, 2001
1IM0
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OUTER MEMBRANE PHOSPHOLIPASE A FROM ESCHERICHIA COLI N156A ACTIVE SITE MUTANT PH 8.3
Descriptor:OUTER MEMBRANE PHSOPHOLIPASE A, B-OCTYLGLUCOSIDE, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Snijder, H.J., Van Eerde, J.H., Kingma, R.L., Kalk, K.H., Dekker, N., Egmond, M.R., Dijkstra, B.W.
Deposit date:2001-05-09
Release date:2001-10-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Structural investigations of the active-site mutant Asn156Ala of outer membrane phospholipase A: function of the Asn-His interaction in the catalytic triad.
Protein Sci., 10, 2001
1QD5
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OUTER MEMBRANE PHOSPHOLIPASE A FROM ESCHERICHIA COLI
Descriptor:OUTER MEMBRANE PHOSPHOLIPASE A, B-OCTYLGLUCOSIDE
Authors:Snijder, H.J., Ubarretxena-Belandia, I., Blaauw, M., Kalk, K.H., Verheij, H.M., Egmond, M.R., Dekker, N., Dijkstra, B.W.
Deposit date:1999-07-09
Release date:1999-10-25
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Structural evidence for dimerization-regulated activation of an integral membrane phospholipase.
Nature, 401, 1999
1QD6
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OUTER MEMBRANE PHOSPHOLIPASE A FROM ESCHERICHIA COLI
Descriptor:OUTER MEMBRANE PHOSPHOLIPASE (OMPLA), PROTEIN (OUTER MEMBRANE PHOSPHOLIPASE (OMPLA)), CALCIUM ION, ...
Authors:Snijder, H.J., Ubarretxena-Belandia, I., Blaauw, M., Kalk, K.H., Verheij, H.M., Egmond, M.R., Dekker, N., Dijkstra, B.W.
Deposit date:1999-07-09
Release date:1999-10-25
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural evidence for dimerization-regulated activation of an integral membrane phospholipase.
Nature, 401, 1999
1I78
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CRYSTAL STRUCTURE OF OUTER MEMBRANE PROTEASE OMPT FROM ESCHERICHIA COLI
Descriptor:PROTEASE VII, B-OCTYLGLUCOSIDE, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Vandeputte-Rutten, L., Kramer, R.A., Kroon, J., Dekker, N., Egmond, M.R., Gros, P.
Deposit date:2001-03-08
Release date:2001-10-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of the outer membrane protease OmpT from Escherichia coli suggests a novel catalytic site.
EMBO J., 20, 2001
4BTJ
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TTBK1 IN COMPLEX WITH ATP
Descriptor:TAU-TUBULIN KINASE 1, ADENOSINE-5'-DIPHOSPHATE, PHOSPHATE ION, ...
Authors:Xue, Y., Wan, P., Hillertz, P., Schweikart, F., Zhao, Y., Wissler, L., Dekker, N.
Deposit date:2013-06-18
Release date:2013-09-25
Last modified:2017-03-29
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:X-Ray Structural Analysis of Tau-Tubulin Kinase 1 and its Interactions with Small Molecular Inhibitors.
Chemmedchem, 8, 2013
4BTK
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TTBK1 IN COMPLEX WITH INHIBITOR
Descriptor:TAU-TUBULIN KINASE 1, DIMETHYL SULFOXIDE, 4-[3-HYDROXYANILINO]-6,7-DIMETHOXYQUINAZOLINE
Authors:Xue, Y., Wan, P., Hillertz, P., Schweikart, F., Zhao, Y., Wissler, L., Dekker, N.
Deposit date:2013-06-18
Release date:2013-09-25
Last modified:2017-03-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-Ray Structural Analysis of Tau-Tubulin Kinase 1 and its Interactions with Small Molecular Inhibitors.
Chemmedchem, 8, 2013
4BTM
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TTBK1 IN COMPLEX WITH INHIBITOR
Descriptor:TAU-TUBULIN KINASE 1, SULFATE ION, methyl 2-bromo-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzoate, ...
Authors:Xue, Y., Wan, P., Hillertz, P., Schweikart, F., Zhao, Y., Wissler, L., Dekker, N.
Deposit date:2013-06-18
Release date:2013-09-25
Last modified:2017-03-29
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:X-Ray Structural Analysis of Tau-Tubulin Kinase 1 and its Interactions with Small Molecular Inhibitors.
Chemmedchem, 8, 2013
4QE6
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FXR WITH CDCA AND NCOA-2 PEPTIDE
Descriptor:Bile acid receptor, Nuclear receptor coactivator 2, CHENODEOXYCHOLIC ACID, ...
Authors:Kudlinzki, D., Merk, D., Linhard, V.L., Saxena, K., Sreeramulu, S., Nilsson, E., Dekker, N., Wissler, L., Bamberg, K., Schubert-Zsilavecz, M., Schwalbe, H.
Deposit date:2014-05-15
Release date:2015-08-12
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.648 Å)
Cite:FXR with CDCA and NCoA-2 peptide
To be Published
4QE8
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FXR WITH DM175 AND NCOA-2 PEPTIDE
Descriptor:Bile acid receptor, Nuclear receptor coactivator 2, 4-({2-[(4-tert-butylbenzoyl)amino]benzoyl}amino)benzoic acid, ...
Authors:Kudlinzki, D., Merk, D., Linhard, V.L., Saxena, K., Sreeramulu, S., Nilsson, E., Dekker, N., Wissler, L., Bamberg, K., Schubert-Zsilavecz, M., Schwalbe, H.
Deposit date:2014-05-15
Release date:2015-08-12
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:FXR with DM175 and NCoA-2 peptide
To be Published
5NDD
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CRYSTAL STRUCTURE OF A THERMOSTABILISED HUMAN PROTEASE-ACTIVATED RECEPTOR-2 (PAR2) IN COMPLEX WITH AZ8838 AT 2.8 ANGSTROM RESOLUTION
Descriptor:Lysozyme,Proteinase-activated receptor 2,Soluble cytochrome b562,Proteinase-activated receptor 2, (~{S})-(4-fluoranyl-2-propyl-phenyl)-(1~{H}-imidazol-2-yl)methanol, SODIUM ION, ...
Authors:Cheng, R.K.Y., Fiez-Vandal, C., Schlenker, O., Edman, K., Aggeler, B., Brown, D.G., Brown, G., Cooke, R.M., Dumelin, C.E., Dore, A.S., Geschwindner, S., Grebner, C., Hermansson, N.-O., Jazayeri, A., Johansson, P., Leong, L., Prihandoko, R., Rappas, M., Soutter, H., Snijder, A., Sundstrom, L., Tehan, B., Thornton, P., Troast, D., Wiggin, G., Zhukov, A., Marshall, F.H., Dekker, N.
Deposit date:2017-03-08
Release date:2017-05-03
Last modified:2017-05-17
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Structural insight into allosteric modulation of protease-activated receptor 2.
Nature, 545, 2017
5NDZ
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CRYSTAL STRUCTURE OF A THERMOSTABILISED HUMAN PROTEASE-ACTIVATED RECEPTOR-2 (PAR2) IN COMPLEX WITH AZ3451 AT 3.6 ANGSTROM RESOLUTION
Descriptor:Lysozyme,Proteinase-activated receptor 2,Soluble cytochrome b562,Proteinase-activated receptor 2, 2-(6-bromanyl-1,3-benzodioxol-5-yl)-~{N}-(4-cyanophenyl)-1-[(1~{S})-1-cyclohexylethyl]benzimidazole-5-carboxamide, SODIUM ION
Authors:Cheng, R.K.Y., Fiez-Vandal, C., Schlenker, O., Edman, K., Aggeler, B., Brown, D.G., Brown, G., Cooke, R.M., Dumelin, C.E., Dore, A.S., Geschwindner, S., Grebner, C., Hermansson, N.-O., Jazayeri, A., Johansson, P., Leong, L., Prihandoko, R., Rappas, M., Soutter, H., Snijder, A., Sundstrom, L., Tehan, B., Thornton, P., Troast, D., Wiggin, G., Zhukov, A., Marshall, F.H., Dekker, N.
Deposit date:2017-03-09
Release date:2017-05-03
Last modified:2017-05-17
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural insight into allosteric modulation of protease-activated receptor 2.
Nature, 545, 2017
5NJ6
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CRYSTAL STRUCTURE OF A THERMOSTABILISED HUMAN PROTEASE-ACTIVATED RECEPTOR-2 (PAR2) IN TERNARY COMPLEX WITH FAB3949 AND AZ7188 AT 4.0 ANGSTROM RESOLUTION
Descriptor:Proteinase-activated receptor 2,Soluble cytochrome b562,Proteinase-activated receptor 2, Fab3949 H, Fab3949 L
Authors:Cheng, R.K.Y., Fiez-Vandal, C., Schlenker, O., Edman, K., Aggeler, B., Brown, D.G., Brown, G., Cooke, R.M., Dumelin, C.E., Dore, A.S., Geschwindner, S., Grebner, C., Hermansson, N.-O., Jazayeri, A., Johansson, P., Leong, L., Prihandoko, R., Rappas, M., Soutter, H., Snijder, A., Sundstrom, L., Tehan, B., Thornton, P., Troast, D., Wiggin, G., Zhukov, A., Marshall, F.H., Dekker, N.
Deposit date:2017-03-28
Release date:2017-05-03
Last modified:2017-05-17
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structural insight into allosteric modulation of protease-activated receptor 2.
Nature, 545, 2017
5G3M
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DISCOVERY OF A NOVEL SECRETED PHOSPHOLIPASE A2 (SPLA2) INHIBITOR.
Descriptor:GROUP 10 SECRETORY PHOSPHOLIPASE A2, CALCIUM ION, DIMETHYL SULFOXIDE, ...
Authors:Sandmark, J., Bodin, C., Hallberg, K.
Deposit date:2016-04-29
Release date:2016-09-14
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Discovery of Azd2716: A Novel Secreted Phospholipase A2 (Spla2) Inhibitor for the Treatment of Coronary Artery Disease
Acs Med.Chem.Lett., 7, 2016
5G3N
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DISCOVERY OF A NOVEL SECRETED PHOSPHOLIPASE A2 (SPLA2) INHIBITOR.
Descriptor:PHOSPHOLIPASE A2, MEMBRANE ASSOCIATED, CALCIUM ION, ...
Authors:Sandmark, J., Bodin, C., Hallberg, K.
Deposit date:2016-04-29
Release date:2016-09-14
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of Azd2716: A Novel Secreted Phospholipase A2 (Spla2) Inhibitor for the Treatment of Coronary Artery Disease
Acs Med.Chem.Lett., 7, 2016