6HL0
Crystal Structure of Farnesoid X receptor (FXR) with bound NCoA-2 peptide
Summary for 6HL0
Entry DOI | 10.2210/pdb6hl0/pdb |
Descriptor | Bile acid receptor, NCoA-2 peptide (Nuclear receptor coactivator 2), LYS-GLU-ASN-ALA-LEU-LEU-ARG-TYR-LEU-LEU-ASP-LYS-ASP (3 entities in total) |
Functional Keywords | activator, dna-binding, receptor, repressor, complex, nuclear protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 28753.05 |
Authors | Kudlinzki, D.,Merk, D.,Linhard, V.L.,Saxena, K.,Schubert-Zsilavecz, M.,Schwalbe, H. (deposition date: 2018-09-10, release date: 2019-05-29, Last modification date: 2024-01-24) |
Primary citation | Merk, D.,Sreeramulu, S.,Kudlinzki, D.,Saxena, K.,Linhard, V.,Gande, S.L.,Hiller, F.,Lamers, C.,Nilsson, E.,Aagaard, A.,Wissler, L.,Dekker, N.,Bamberg, K.,Schubert-Zsilavecz, M.,Schwalbe, H. Molecular tuning of farnesoid X receptor partial agonism. Nat Commun, 10:2915-2915, 2019 Cited by PubMed: 31266946DOI: 10.1038/s41467-019-10853-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.66 Å) |
Structure validation
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