6HL1

Crystal Structure of Farnesoid X receptor (FXR) with bound NCoA-2 peptide and CDCA

Replaces:  4QE6

Summary for 6HL1

• Entry DOI: 10.2210/pdb6hl1/pdb
• Descriptor: Bile acid receptor, NCoA-2 peptide (Nuclear receptor coactivator 2), LYS-GLU-ASN-ALA-LEU-LEU-ARG-TYR-LEU-LEU-ASP-LYS-ASP, CHENODEOXYCHOLIC ACID, ... (4 entities in total)
• Functional Keywords: activator, dna-binding, receptor, repressor, complex, nuclear protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 29145.63

Authors

Kudlinzki, D.,Merk, D.,Linhard, V.L.,Saxena, K.,Schubert-Zsilavecz, M.,Schwalbe, H. (deposition date: 2018-09-10, release date: 2019-05-29, Last modification date: 2024-01-24)

• Primary citation: Merk, D.,Sreeramulu, S.,Kudlinzki, D.,Saxena, K.,Linhard, V.,Gande, S.L.,Hiller, F.,Lamers, C.,Nilsson, E.,Aagaard, A.,Wissler, L.,Dekker, N.,Bamberg, K.,Schubert-Zsilavecz, M.,Schwalbe, H.; Molecular tuning of farnesoid X receptor partial agonism.; Nat Commun, 10:2915-2915, 2019; PubMed: 31266946; DOI: 10.1038/s41467-019-10853-2

Experimental method

X-RAY DIFFRACTION (1.599 Å)