6HL1
Crystal Structure of Farnesoid X receptor (FXR) with bound NCoA-2 peptide and CDCA
Replaces: 4QE6Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Bile acid receptor | polymer | 232 | 27159.2 | 1 | UniProt (Q96RI1) Pfam (PF00104) | Homo sapiens (Human) | Farnesoid X-activated receptor,Farnesol receptor HRR-1,Nuclear receptor subfamily 1 group H member 4,Retinoid X receptor-interacting protein 14,RXR-interacting protein 14 |
| 2 | B (B) | NCoA-2 peptide (Nuclear receptor coactivator 2), LYS-GLU-ASN-ALA-LEU-LEU-ARG-TYR-LEU-LEU-ASP-LYS-ASP | polymer | 13 | 1593.8 | 1 | UniProt (by SIFTS) (Q15596) | Homo sapiens | |
| 3 | C (A) | CHENODEOXYCHOLIC ACID | non-polymer | 392.6 | 1 | Chemie (JN3) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 182 | Chemie (HOH) |
Sequence modifications
A: 244 - 472 (UniProt: Q96RI1)
| PDB | External Database | Details |
|---|---|---|
| Ser 241 | - | expression tag |
| His 242 | - | expression tag |
| Met 243 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28753.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 392.6 | |
| All* | Total formula weight | 29145.6 |
