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4HAT
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CRYSTAL STRUCTURE OF CRM1 INHIBITOR LEPTOMYCIN B IN COMPLEX WITH CRM1-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Sun, Q., Chook, Y.M.
Deposit date:2012-09-27
Release date:2013-01-09
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HB2
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CRYSTAL STRUCTURE OF CRM1-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Sun, Q., Chook, Y.M.
Deposit date:2012-09-27
Release date:2013-01-09
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4WVF
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CRYSTAL STRUCTURE OF KPT276 IN COMPLEX WITH CRM1-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Crm1p, ...
Authors:Sun, Q., Chook, Y.
Deposit date:2014-11-05
Release date:2015-07-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination.
Nat.Neurosci., 18, 2015
2CHS
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CRYSTAL STRUCTURES OF THE MONOFUNCTIONAL CHORISMATE MUTASE FROM BACILLUS SUBTILIS AND ITS COMPLEX WITH A TRANSITION STATE ANALOG
Descriptor:CHORISMATE MUTASE
Authors:Chook, Y.M., Ke, H., Lipscomb, W.N.
Deposit date:1994-04-08
Release date:1994-07-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of the monofunctional chorismate mutase from Bacillus subtilis and its complex with a transition state analog.
Proc.Natl.Acad.Sci.USA, 90, 1993
4HAW
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CRYSTAL STRUCTURE OF CRM1 INHIBITOR LEPTOMYCIN B IN COMPLEX WITH CRM1(K548A)-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Sun, Q., Chook, Y.M.
Deposit date:2012-09-27
Release date:2013-01-09
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HAZ
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CRYSTAL STRUCTURE OF CRM1 INHIBITOR LEPTOMYCIN B IN COMPLEX WITH CRM1(R543S,K548E,K579Q)-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Sun, Q., Chook, Y.M.
Deposit date:2012-09-27
Release date:2013-01-09
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HAU
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CRYSTAL STRUCTURE OF CRM1 INHIBITOR RATJADONE A IN COMPLEX WITH CRM1-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Sun, Q., Chook, Y.M.
Deposit date:2012-09-27
Release date:2013-01-09
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HAV
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CRYSTAL STRUCTURE OF CRM1 INHIBITOR ANGUINOMYCIN A IN COMPLEX WITH CRM1-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Sun, Q., Chook, Y.M.
Deposit date:2012-09-27
Release date:2013-01-09
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
6CIT
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CRYSTAL STRUCTURE OF MVM NS2 NES PEPTIDE IN COMPLEX WITH CRM1-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Fung, H.Y.J., Chook, Y.M.
Deposit date:2018-02-25
Release date:2018-06-27
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.027 Å)
Cite:Correlation of CRM1-NES affinity with nuclear export activity.
Mol. Biol. Cell, 29, 2018
4HB4
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CRYSTAL STRUCTURE OF CRM1 INHIBITOR LEPTOMYCIN B IN COMPLEX WITH CRM1(537DLTVK541/GLCEQ)-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Sun, Q., Chook, Y.M.
Deposit date:2012-09-27
Release date:2013-01-09
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
5UWP
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CRYSTAL STRUCTURE OF MDIA2 NES PEPTIDE IN COMPLEX WITH CRM1-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Fung, H.Y.J., Chook, Y.M.
Deposit date:2017-02-21
Release date:2017-03-22
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.054 Å)
Cite:Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.
Elife, 6, 2017
5DIF
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CRYSTAL STRUCTURE OF CPEB4 NES PEPTIDE IN COMPLEX WITH CRM1-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Fung, H.Y., Chook, Y.M.
Deposit date:2015-08-31
Release date:2015-09-16
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.092 Å)
Cite:Structural determinants of nuclear export signal orientation in binding to exportin CRM1.
Elife, 4, 2015
4GMX
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CRYSTAL STRUCTURE OF KPT185 IN COMPLEX WITH CRM1-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Sun, Q., Chook, Y.M.
Deposit date:2012-08-16
Release date:2012-10-17
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia.
Blood, 120, 2012
5UWI
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CRYSTAL STRUCTURE OF HDAC5 NES PEPTIDE IN COMPLEX WITH CRM1-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Fung, H.Y.J., Chook, Y.M.
Deposit date:2017-02-21
Release date:2017-03-22
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.143 Å)
Cite:Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.
Elife, 6, 2017
5UWW
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CRYSTAL STRUCTURE OF DEAF1 PEPTIDE IN COMPLEX WITH CRM1 K579A MUTANT-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Fung, H.Y.J., Chook, Y.M.
Deposit date:2017-02-21
Release date:2017-03-22
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.152 Å)
Cite:Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.
Elife, 6, 2017
1COM
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THE MONOFUNCTIONAL CHORISMATE MUTASE FROM BACILLUS SUBTILIS: STRUCTURE DETERMINATION OF CHORISMATE MUTASE AND ITS COMPLEXES WITH A TRANSITION STATE ANALOG AND PREPHENATE, AND IMPLICATIONS ON THE MECHANISM OF ENZYMATIC REACTION
Descriptor:CHORISMATE MUTASE, PREPHENIC ACID
Authors:Chook, Y.M., Ke, H., Lipscomb, W.N.
Deposit date:1994-04-08
Release date:1994-06-22
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The monofunctional chorismate mutase from Bacillus subtilis. Structure determination of chorismate mutase and its complexes with a transition state analog and prephenate, and implications for the mechanism of the enzymatic reaction.
J.Mol.Biol., 240, 1994
2CHT
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CRYSTAL STRUCTURES OF THE MONOFUNCTIONAL CHORISMATE MUTASE FROM BACILLUS SUBTILIS AND ITS COMPLEX WITH A TRANSITION STATE ANALOG
Descriptor:CHORISMATE MUTASE, 8-HYDROXY-2-OXA-BICYCLO[3.3.1]NON-6-ENE-3,5-DICARBOXYLIC ACID
Authors:Chook, Y.M., Ke, H., Lipscomb, W.N.
Deposit date:1994-04-08
Release date:1994-07-31
Last modified:2020-01-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of the monofunctional chorismate mutase from Bacillus subtilis and its complex with a transition state analog.
Proc.Natl.Acad.Sci.USA, 90, 1993
4HB0
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CRYSTAL STRUCTURE OF CRM1 INHIBITOR LEPTOMYCIN B IN COMPLEX WITH CRM1(K541Q,K542Q,R543S,K545Q,K548Q,K579Q)-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Sun, Q., Chook, Y.M.
Deposit date:2012-09-27
Release date:2013-01-09
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
6X2U
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CRYSTAL STRUCTURE OF PKINES PEPTIDE BOUND TO CRM1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Baumhardt, J.M.
Deposit date:2020-05-21
Release date:2020-07-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation.
Mol.Biol.Cell, 2020
4GPT
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CRYSTAL STRUCTURE OF KPT251 IN COMPLEX WITH CRM1-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Sun, Q., Chook, Y.M.
Deposit date:2012-08-21
Release date:2012-09-05
Last modified:2013-01-23
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells.
Leukemia, 27, 2013
5UWJ
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CRYSTAL STRUCTURE OF FMRP NES PEPTIDE IN COMPLEX WITH CRM1-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Fung, H.Y.J., Chook, Y.M.
Deposit date:2017-02-21
Release date:2017-03-22
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.221 Å)
Cite:Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.
Elife, 6, 2017
5UWR
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CRYSTAL STRUCTURE OF CDC7 NES PEPTIDE (EXTENDED) IN COMPLEX WITH CRM1-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Fung, H.Y.J., Chook, Y.M.
Deposit date:2017-02-21
Release date:2017-03-22
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.
Elife, 6, 2017
5UWU
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CRYSTAL STRUCTURE OF SMAD4 NES PEPTIDE IN COMPLEX WITH CRM1-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Fung, H.Y.J., Chook, Y.M.
Deposit date:2017-02-21
Release date:2017-03-22
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.
Elife, 6, 2017
5UWH
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CRYSTAL STRUCTURE OF PAXILLIN NES PEPTIDE IN COMPLEX WITH CRM1-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Fung, H.Y.J., Chook, Y.M.
Deposit date:2017-02-21
Release date:2017-03-22
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.
Elife, 6, 2017
5UWQ
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CRYSTAL STRUCTURE OF CDC7 NES PEPTIDE IN COMPLEX WITH CRM1-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Fung, H.Y.J., Chook, Y.M.
Deposit date:2017-02-21
Release date:2017-03-22
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.278 Å)
Cite:Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.
Elife, 6, 2017
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