Author results

6NZT
  • Download 6nzt
  • View 6nzt
Molmil generated image of 6nzt
CRYSTAL STRUCTURE OF HCV NS3/4A PROTEASE IN COMPLEX WITH VOXILAPREVIR
分子名称:HCV NS3/4A protease, Voxilaprevir, ZINC ION, ...
著者Appleby, T.C., Taylor, J.G.
登録日2019-02-14
公開日2019-07-10
最終更新日2019-08-21
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi®.
Bioorg.Med.Chem.Lett., 29, 2019
6NZV
  • Download 6nzv
  • View 6nzv
Molmil generated image of 6nzv
CRYSTAL STRUCTURE OF HCV NS3/4A PROTEASE IN COMPLEX WITH COMPOUND 12
分子名称:HCV NS3/4A protease, (1aR,5S,8S,9S,10R,22aR)-5-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-9-ethyl-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxamide, ZINC ION, ...
著者Appleby, T.C., Taylor, J.G.
登録日2019-02-14
公開日2019-07-10
最終更新日2019-08-21
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi®.
Bioorg.Med.Chem.Lett., 29, 2019
6INF
  • Download 6inf
  • View 6inf
Molmil generated image of 6inf
A GLYCOSYLTRANSFERASE COMPLEX WITH UDP
分子名称:UDP-glycosyltransferase 76G1, URIDINE-5'-DIPHOSPHATE
著者Zhu, X., Yang, T., Naismith, J.H.
登録日2018-10-25
公開日2019-07-31
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Hydrophobic recognition allows the glycosyltransferase UGT76G1 to catalyze its substrate in two orientations.
Nat Commun, 10, 2019
6ING
  • Download 6ing
  • View 6ing
Molmil generated image of 6ing
A COMPLEX STRUCTURE OF H25A MUTANT OF GLYCOSYLTRANSFERASE WITH UDP
分子名称:UDP-glycosyltransferase 76G1, URIDINE-5'-DIPHOSPHATE, GLYCEROL
著者Zhu, X., Naismith, J.H.
登録日2018-10-25
公開日2019-07-31
実験手法X-RAY DIFFRACTION (1.698 Å)
主引用文献Hydrophobic recognition allows the glycosyltransferase UGT76G1 to catalyze its substrate in two orientations.
Nat Commun, 10, 2019
6INI
  • Download 6ini
  • View 6ini
Molmil generated image of 6ini
A GLYCOSYLTRANSFERASE COMPLEX WITH UDP AND THE PRODUCT
分子名称:UDP-glycosyltransferase 76G1, URIDINE-5'-DIPHOSPHATE, GLYCEROL, ...
著者Zhu, X., Yang, T., Naismith, J.H.
登録日2018-10-25
公開日2019-07-31
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Hydrophobic recognition allows the glycosyltransferase UGT76G1 to catalyze its substrate in two orientations.
Nat Commun, 10, 2019
4EFO
  • Download 4efo
  • View 4efo
Molmil generated image of 4efo
CRYSTAL STRUCTURE OF THE UBIQUITIN-LIKE DOMAIN OF HUMAN TBK1
分子名称:Serine/threonine-protein kinase TBK1
著者Li, J., Li, J., Miyahira, A., Sun, J., Liu, Y., Cheng, G., Liang, H.
登録日2012-03-30
公開日2012-06-27
実験手法X-RAY DIFFRACTION (1.769 Å)
主引用文献Crystal structure of the ubiquitin-like domain of human TBK1.
Protein Cell, 3, 2012
4J0U
  • Download 4j0u
  • View 4j0u
Molmil generated image of 4j0u
CRYSTAL STRUCTURE OF IFIT5/ISG58
分子名称:Interferon-induced protein with tetratricopeptide repeats 5
著者Liu, Y., Liang, H., Feng, F., Yuan, L., Wang, Y.E., Crowley, C., Lv, Z., Li, J., Zeng, S., Cheng, G.
登録日2013-01-31
公開日2013-02-13
実験手法X-RAY DIFFRACTION (1.969 Å)
主引用文献Crystal Structure of IFIT5
To be Published
3ANM
  • Download 3anm
  • View 3anm
Molmil generated image of 3anm
CRYSTAL STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE (DXR) COMPLEXED WITH 5-PHENYLPYRIDIN-2-YLMETHYLPHOSPHONIC ACID
分子名称:1-deoxy-D-xylulose 5-phosphate reductoisomerase, [(5-phenylpyridin-2-yl)methyl]phosphonic acid, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Endo, K., Kato, M., Deng, L., Song, Y., Yajima, S.
登録日2010-09-03
公開日2011-02-23
最終更新日2011-10-19
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate Complexes
ACS Med Chem Lett, 2, 2011
3ANN
  • Download 3ann
  • View 3ann
Molmil generated image of 3ann
CRYSTAL STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE (DXR) COMPLEXED WITH QUINOLIN-2-YLMETHYLPHOSPHONIC ACID
分子名称:1-deoxy-D-xylulose 5-phosphate reductoisomerase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (quinolin-2-ylmethyl)phosphonic acid
著者Endo, K., Kato, M., Deng, L., Song, Y., Yajima, S.
登録日2010-09-03
公開日2011-02-23
最終更新日2011-10-19
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate Complexes
ACS Med Chem Lett, 2, 2011
4NOM
  • Download 4nom
  • View 4nom
Molmil generated image of 4nom
CRYSTAL STRUCTURE OF ASPARAGINYL ENDOPEPTIDASE (AEP)/LEGUMAIN ACTIVATED AT PH 4.5
分子名称:Legumain
著者Zhao, L., Hua, T., Ru, H., Ni, X., Shaw, N., Jiao, L., Ding, W., Qu, L., Ouyang, S., Liu, Z.J.
登録日2013-11-19
公開日2014-02-19
最終更新日2014-03-19
実験手法X-RAY DIFFRACTION (2.006 Å)
主引用文献Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage.
Cell Res., 24, 2014
3ANL
  • Download 3anl
  • View 3anl
Molmil generated image of 3anl
CRYSTAL STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE (DXR) COMPLEXED WITH PYRIDIN-2-YLMETHYLPHOSPHONIC ACID
分子名称:1-deoxy-D-xylulose 5-phosphate reductoisomerase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (pyridin-2-ylmethyl)phosphonic acid
著者Endo, K., Kato, M., Deng, L., Song, Y., Yajima, S.
登録日2010-09-03
公開日2011-02-23
最終更新日2011-10-19
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate Complexes
ACS Med Chem Lett, 2, 2011
6INH
  • Download 6inh
  • View 6inh
Molmil generated image of 6inh
A GLYCOSYLTRANSFERASE WITH UDP AND THE SUBSTRATE
分子名称:UDP-glycosyltransferase 76G1, URIDINE-5'-DIPHOSPHATE, 1-O-[(8alpha,9beta,10alpha,13alpha)-13-(beta-D-glucopyranosyloxy)-18-oxokaur-16-en-18-yl]-beta-D-glucopyranose, ...
著者Zhu, X.
登録日2018-10-25
公開日2019-07-31
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Hydrophobic recognition allows the glycosyltransferase UGT76G1 to catalyze its substrate in two orientations.
Nat Commun, 10, 2019
4EF4
  • Download 4ef4
  • View 4ef4
Molmil generated image of 4ef4
CRYSTAL STRUCTURE OF STING CTD COMPLEX WITH C-DI-GMP
分子名称:Transmembrane protein 173, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CALCIUM ION
著者Ouyang, S., Ru, H., Shaw, N., Jiang, Y., Niu, F., Zhu, Y., Qiu, W., Li, Y., Liu, Z.-J.
登録日2012-03-29
公開日2012-05-16
最終更新日2013-07-03
実験手法X-RAY DIFFRACTION (2.147 Å)
主引用文献Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding
Immunity, 36, 2012
4GHU
  • Download 4ghu
  • View 4ghu
Molmil generated image of 4ghu
CRYSTAL STRUCTURE OF TRAF3/CARDIF
分子名称:TNF receptor-associated factor 3, Mitochondrial antiviral-signaling protein
著者Zhang, P.
登録日2012-08-08
公開日2012-11-28
実験手法X-RAY DIFFRACTION (2.199 Å)
主引用文献Single Amino Acid Substitutions Confer the Antiviral Activity of the TRAF3 Adaptor Protein onto TRAF5
Sci.Signal., 5, 2012
4JBM
  • Download 4jbm
  • View 4jbm
Molmil generated image of 4jbm
STRUCTURE OF MURINE DNA BINDING PROTEIN BOUND WITH DS DNA
分子名称:Interferon-inducible protein AIM2, DNA (5'-D(*GP*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*C)-3')
著者Ru, H., Ni, X., Crowley, C., Zhao, L., Ding, W., Hung, L.-W., Shaw, N., Cheng, G., Liu, Z.-J.
登録日2013-02-19
公開日2013-06-26
実験手法X-RAY DIFFRACTION (2.218 Å)
主引用文献Structural basis for termination of AIM2-mediated signaling by p202
Cell Res., 23, 2013
5H1Y
  • Download 5h1y
  • View 5h1y
Molmil generated image of 5h1y
CRYSTAL STRUCTURE OF THE DDX41 DEAD DOMAIN IN COMPLEX WITH SO42- AND MG2+
分子名称:Probable ATP-dependent RNA helicase DDX41, SULFATE ION, MAGNESIUM ION
著者Jiang, Y., Ouyang, S., Liu, Z.J.
登録日2016-10-13
公開日2017-01-18
最終更新日2017-01-25
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Structural and functional analyses of human DDX41 DEAD domain
Protein Cell, 8, 2017
1JXH
  • Download 1jxh
  • View 1jxh
Molmil generated image of 1jxh
4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE KINASE FROM SALMONELLA TYPHIMURIUM
分子名称:PHOSPHOMETHYLPYRIMIDINE KINASE, SULFATE ION
著者Cheng, G., Bennett, E.M., Begley, T.P., Ealick, S.E.
登録日2001-09-07
公開日2002-02-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase from Salmonella typhimurium at 2.3 A resolution.
Structure, 10, 2002
4EF5
  • Download 4ef5
  • View 4ef5
Molmil generated image of 4ef5
CRYSTAL STRUCTURE OF STING CTD
分子名称:Transmembrane protein 173
著者Ouyang, S., Ru, H., Shaw, N., Jiang, Y., Niu, F., Zhu, Y., Qiu, W., Li, Y., Liu, Z.-J.
登録日2012-03-29
公開日2012-05-16
最終更新日2013-07-03
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding
Immunity, 36, 2012
3SR4
  • Download 3sr4
  • View 3sr4
Molmil generated image of 3sr4
CRYSTAL STRUCTURE OF HUMAN DOT1L IN COMPLEX WITH A SELECTIVE INHIBITOR
分子名称:Histone-lysine N-methyltransferase, H3 lysine-79 specific, (2S)-2-azanyl-4-[[(2S,3S,4R,5R)-5-[6-(methylamino)purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, ...
著者Diao, J., Chen, P., Yao, Y., Prasad, B.V.V., Song, Y.
登録日2011-07-06
公開日2011-10-05
最終更新日2011-11-16
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Selective Inhibitors of Histone Methyltransferase DOT1L: Design, Synthesis, and Crystallographic Studies.
J.Am.Chem.Soc., 133, 2011
4NOK
  • Download 4nok
  • View 4nok
Molmil generated image of 4nok
CRYSTAL STRUCTURE OF PROENZYME ASPARAGINYL ENDOPEPTIDASE (AEP)/LEGUMAIN AT PH 7.5
分子名称:Legumain
著者Zhao, L., Hua, T., Ru, H., Ni, X., Shaw, N., Jiao, L., Ding, W., Qu, L., Ouyang, S., Liu, Z.J.
登録日2013-11-19
公開日2014-02-19
最終更新日2014-03-19
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage.
Cell Res., 24, 2014
4QGU
  • Download 4qgu
  • View 4qgu
Molmil generated image of 4qgu
PROTEIN DOMAIN COMPLEX WITH SSDNA
分子名称:Gamma-interferon-inducible protein 16, DNA (5'-D(P*AP*GP*GP*CP*CP*GP*GP*CP*GP*TP*GP*A)-3')
著者Ni, X., Ru, H., Zhao, L., Shaw, N., Ding, W., Songying, O., Liu, Z.-J.
登録日2014-05-25
公開日2015-06-17
最終更新日2016-07-20
実験手法X-RAY DIFFRACTION (2.545 Å)
主引用文献New insights into the structural basis of DNA recognition by HINa and HINb domains of IFI16.
J Mol Cell Biol, 8, 2016
3RAS
  • Download 3ras
  • View 3ras
Molmil generated image of 3ras
CRYSTAL STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE (DXR) COMPLEXED WITH A LIPOPHILIC PHOSPHONATE INHIBITOR
分子名称:1-deoxy-D-xylulose 5-phosphate reductoisomerase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-(N-HYDROXYACETAMIDO)-1-(3,4-DICHLOROPHENYL)PROPYLPHOSPHONIC ACID, ...
著者Diao, J., Deng, L., Prasad, B.V.V., Song, Y.
登録日2011-03-28
公開日2011-05-25
最終更新日2012-07-25
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase by lipophilic phosphonates: SAR, QSAR, and crystallographic studies.
J.Med.Chem., 54, 2011
3M0A
  • Download 3m0a
  • View 3m0a
Molmil generated image of 3m0a
CRYSTAL STRUCTURE OF TRAF2:CIAP2 COMPLEX
分子名称:TNF receptor-associated factor 2, Baculoviral IAP repeat-containing protein 3, ZINC ION
著者Kabaleeswaran, V., Wu, H.
登録日2010-03-02
公開日2010-04-28
最終更新日2015-07-29
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation.
Mol.Cell, 38, 2010
1JXI
  • Download 1jxi
  • View 1jxi
Molmil generated image of 1jxi
4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE KINASE FROM SALMONELLA TYPHIMURIUM COMPLEXED WITH 4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE
分子名称:PHOSPHOMETHYLPYRIMIDINE KINASE, SULFATE ION, 4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE
著者Cheng, G., Bennett, E.M., Begley, T.P., Ealick, S.E.
登録日2001-09-07
公開日2002-02-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.64 Å)
主引用文献Crystal structure of 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase from Salmonella typhimurium at 2.3 A resolution.
Structure, 10, 2002
4J1J
  • Download 4j1j
  • View 4j1j
Molmil generated image of 4j1j
LEANYER ORTHOBUNYAVIRUS NUCLEOPROTEIN-SSDNA COMPLEX
分子名称:Nucleocapsid, DNA (5'-D(P*AP*CP*CP*AP*AP*AP*CP*AP*AP*CP*CP*CP*AP*CP*CP*CP*A)-3')
著者Niu, F., Shaw, N., Wang, Y., Jiao, L., Ding, W., Li, X., Zhu, P., Upur, H., Ouyang, S., Cheng, G., Liu, Z.J.
登録日2013-02-01
公開日2013-04-10
最終更新日2014-11-05
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structure of the Leanyer orthobunyavirus nucleoprotein-RNA complex reveals unique architecture for RNA encapsidation.
Proc.Natl.Acad.Sci.USA, 110, 2013
<12>