6PIS
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4I9W
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3UM7
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3EWE
| Crystal Structure of the Nup85/Seh1 Complex | Descriptor: | Nucleoporin NUP85, Nucleoporin SEH1 | Authors: | Brohawn, S.G, Leksa, N.C, Rajashankar, K.R, Schwartz, T.U. | Deposit date: | 2008-10-14 | Release date: | 2008-11-11 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structural evidence for common ancestry of the nuclear pore complex and vesicle coats. Science, 322, 2008
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4WFH
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4WFG
| Human TRAAK K+ channel in a Tl+ bound conductive conformation | Descriptor: | ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ... | Authors: | Brohawn, S.G, MacKinnon, R. | Deposit date: | 2014-09-15 | Release date: | 2014-12-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel. Nature, 516, 2014
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4WFE
| Human TRAAK K+ channel in a K+ bound conductive conformation | Descriptor: | ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ... | Authors: | Brohawn, S.G, MacKinnon, R. | Deposit date: | 2014-09-15 | Release date: | 2014-12-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel. Nature, 516, 2014
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4WFF
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3JRP
| SEC13 with NUP145C (AA109-179) insertion blade | Descriptor: | FUSION PROTEIN OF PROTEIN TRANSPORT PROTEIN SEC13 AND NUCLEOPORIN NUP145 | Authors: | Brohawn, S.G, Gogola, M, Schwartz, T.U. | Deposit date: | 2009-09-08 | Release date: | 2009-10-27 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Molecular architecture of the Nup84-Nup145C-Sec13 edge element in the nuclear pore complex lattice. Nat.Struct.Mol.Biol., 16, 2009
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3JRO
| NUP84-NUP145C-SEC13 edge element of the NPC lattice | Descriptor: | Fusion Protein of Protein Transport Protein SEC13 and Nucleoporin NUP145, Nucleoporin NUP84 | Authors: | Brohawn, S.G, Schwartz, T.U. | Deposit date: | 2009-09-08 | Release date: | 2009-10-27 | Last modified: | 2017-08-02 | Method: | X-RAY DIFFRACTION (4.004 Å) | Cite: | Molecular architecture of the Nup84-Nup145C-Sec13 edge element in the nuclear pore complex lattice. Nat.Struct.Mol.Biol., 16, 2009
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7KJR
| Cryo-EM structure of SARS-CoV-2 ORF3a | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Apolipoprotein A-I, ORF3a protein | Authors: | Kern, D.M, Hoel, C.M, Kotecha, A, Brohawn, S.G. | Deposit date: | 2020-10-26 | Release date: | 2020-11-18 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.08 Å) | Cite: | Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs. Nat.Struct.Mol.Biol., 28, 2021
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9C49
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7SK0
| TWIK1 in MSP1D1 lipid nanodisc at pH 7.4 | Descriptor: | N-OCTANE, POTASSIUM ION, Potassium channel subfamily K member 1 | Authors: | Turney, T.S, Brohawn, S.G. | Deposit date: | 2021-10-19 | Release date: | 2021-11-24 | Last modified: | 2022-06-22 | Method: | ELECTRON MICROSCOPY (3.33 Å) | Cite: | Structural Basis for pH-gating of the K + channel TWIK1 at the selectivity filter. Nat Commun, 13, 2022
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7SK1
| TWIK1 in MSP1E3D1 Lipid Nanodisc at pH 5.5 | Descriptor: | N-OCTANE, POTASSIUM ION, Potassium channel subfamily K member 1, ... | Authors: | Turney, T.S, Brohawn, S.G. | Deposit date: | 2021-10-19 | Release date: | 2021-11-24 | Last modified: | 2022-06-22 | Method: | ELECTRON MICROSCOPY (3.43 Å) | Cite: | Structural Basis for pH-gating of the K + channel TWIK1 at the selectivity filter. Nat Commun, 13, 2022
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6XDC
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6UKN
| Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs | Descriptor: | CHLORIDE ION, POTASSIUM ION, Solute carrier family 12 member 7, ... | Authors: | Reid, M.S, Kern, D.M, Brohawn, S.G. | Deposit date: | 2019-10-05 | Release date: | 2020-06-10 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.65 Å) | Cite: | Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs. Elife, 9, 2020
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6WLV
| TASK2 in MSP1D1 lipid nanodisc at pH 6.5 | Descriptor: | POTASSIUM ION, Potassium channel TASK2 | Authors: | Li, B, Brohawn, S.G. | Deposit date: | 2020-04-20 | Release date: | 2020-07-15 | Last modified: | 2020-10-28 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Structural basis for pH gating of the two-pore domain K + channel TASK2. Nature, 586, 2020
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6WM0
| TASK2 in MSP1D1 lipid nanodisc at pH 8.5 | Descriptor: | POTASSIUM ION, Potassium channel TASK2 | Authors: | Li, B, Brohawn, S.G. | Deposit date: | 2020-04-20 | Release date: | 2020-07-15 | Last modified: | 2020-10-28 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | Structural basis for pH gating of the two-pore domain K + channel TASK2. Nature, 586, 2020
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3HXR
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7RTT
| Cryo-EM structure of a TTYH2 cis-dimer | Descriptor: | CALCIUM ION, Protein tweety homolog 2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Li, B, Brohawn, S.G, Hoel, C.M. | Deposit date: | 2021-08-15 | Release date: | 2021-08-25 | Last modified: | 2022-03-09 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca 2+ -dependent switch from intra- to intermembrane dimerization. Nat Commun, 12, 2021
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7RTU
| Cryo-EM structure of a TTYH2 trans-dimer | Descriptor: | Protein tweety homolog 2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Li, B, Brohawn, S.G, Hoel, C.M. | Deposit date: | 2021-08-15 | Release date: | 2021-08-25 | Last modified: | 2022-03-09 | Method: | ELECTRON MICROSCOPY (3.89 Å) | Cite: | Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca 2+ -dependent switch from intra- to intermembrane dimerization. Nat Commun, 12, 2021
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7RTW
| Cryo-EM structure of a TTYH3 cis-dimer | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Li, B, Brohawn, S.G, Hoel, C.M. | Deposit date: | 2021-08-15 | Release date: | 2021-08-25 | Last modified: | 2022-03-09 | Method: | ELECTRON MICROSCOPY (3.23 Å) | Cite: | Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca 2+ -dependent switch from intra- to intermembrane dimerization. Nat Commun, 12, 2021
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7RTV
| Cryo-EM structure of monomeric TTYH2 | Descriptor: | Protein tweety homolog 2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Li, B, Brohawn, S.G, Hoel, C.M. | Deposit date: | 2021-08-15 | Release date: | 2021-09-22 | Last modified: | 2022-04-06 | Method: | ELECTRON MICROSCOPY (3.96 Å) | Cite: | Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca 2+ -dependent switch from intra- to intermembrane dimerization. Nat Commun, 12, 2021
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8F7D
| LRRC8A(T48D):C conformation 2 top focus | Descriptor: | Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | Authors: | Kern, D.M, Brohawn, S.G. | Deposit date: | 2022-11-18 | Release date: | 2023-03-08 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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8F74
| LRRC8A(T48D):C conformation 2 top focus | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | Authors: | Kern, D.M, Brohawn, S.G. | Deposit date: | 2022-11-18 | Release date: | 2023-03-08 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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