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3EWE
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CRYSTAL STRUCTURE OF THE NUP85/SEH1 COMPLEX
Descriptor:Nucleoporin SEH1, Nucleoporin NUP85
Authors:Brohawn, S.G., Leksa, N.C., Rajashankar, K.R., Schwartz, T.U.
Deposit date:2008-10-14
Release date:2008-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structural evidence for common ancestry of the nuclear pore complex and vesicle coats.
Science, 322, 2008
3JRO
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NUP84-NUP145C-SEC13 EDGE ELEMENT OF THE NPC LATTICE
Descriptor:Fusion Protein of Protein Transport Protein SEC13 and Nucleoporin NUP145, Nucleoporin NUP84
Authors:Brohawn, S.G., Schwartz, T.U.
Deposit date:2009-09-08
Release date:2009-10-27
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (4.004 Å)
Cite:Molecular architecture of the Nup84-Nup145C-Sec13 edge element in the nuclear pore complex lattice.
Nat.Struct.Mol.Biol., 16, 2009
3JRP
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SEC13 WITH NUP145C (AA109-179) INSERTION BLADE
Descriptor:FUSION PROTEIN OF PROTEIN TRANSPORT PROTEIN SEC13 AND NUCLEOPORIN NUP145
Authors:Brohawn, S.G., Gogola, M., Schwartz, T.U.
Deposit date:2009-09-08
Release date:2009-10-27
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular architecture of the Nup84-Nup145C-Sec13 edge element in the nuclear pore complex lattice.
Nat.Struct.Mol.Biol., 16, 2009
3UM7
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CRYSTAL STRUCTURE OF THE HUMAN TWO PORE DOMAIN K+ ION CHANNEL TRAAK (K2P4.1)
Descriptor:Potassium channel subfamily K member 4, POTASSIUM ION
Authors:Brohawn, S.G., MacKinnon, R.
Deposit date:2011-11-12
Release date:2012-02-08
Method:X-RAY DIFFRACTION (3.31 Å)
Cite:Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel.
Science, 335, 2012
4I9W
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HUMAN TWO PORE DOMAIN K+ CHANNEL TRAAK (K2P4.1) - FAB COMPLEX STRUCTURE
Descriptor:Potassium channel subfamily K member 4, ANTIBODY FAB FRAGMENT LIGHT CHAIN, ANTIBODY FAB FRAGMENT HEAVY CHAIN, ...
Authors:Brohawn, S.G., Mackinnon, R.
Deposit date:2012-12-05
Release date:2013-01-23
Last modified:2013-02-20
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel.
Proc.Natl.Acad.Sci.USA, 110, 2013
4WFE
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HUMAN TRAAK K+ CHANNEL IN A K+ BOUND CONDUCTIVE CONFORMATION
Descriptor:Potassium channel subfamily K member 4, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ...
Authors:Brohawn, S.G., MacKinnon, R.
Deposit date:2014-09-15
Release date:2014-12-03
Last modified:2014-12-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
Nature, 516, 2014
4WFF
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HUMAN TRAAK K+ CHANNEL IN A K+ BOUND NONCONDUCTIVE CONFORMATION
Descriptor:Potassium channel subfamily K member 4, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ...
Authors:Brohawn, S.G., MacKinnon, R.
Deposit date:2014-09-15
Release date:2014-12-03
Last modified:2014-12-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
Nature, 516, 2014
4WFG
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HUMAN TRAAK K+ CHANNEL IN A TL+ BOUND CONDUCTIVE CONFORMATION
Descriptor:Potassium channel subfamily K member 4, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ...
Authors:Brohawn, S.G., MacKinnon, R.
Deposit date:2014-09-15
Release date:2014-12-03
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (3 Å)
Cite:Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
Nature, 516, 2014
4WFH
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HUMAN TRAAK K+ CHANNEL IN A TL+ BOUND NONCONDUCTIVE CONFORMATION
Descriptor:Potassium channel subfamily K member 4, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ...
Authors:Brohawn, S.G., MacKinnon, R.
Deposit date:2014-09-15
Release date:2014-12-03
Last modified:2015-02-04
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
Nature, 516, 2014
6PIS
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MOUSE TWO PORE DOMAIN K+ CHANNEL TRAAK (K2P4.1) - FAB COMPLEX STRUCTURE
Descriptor:Potassium channel subfamily K member 4, ANTIBODY FAB FRAGMENT LIGHT CHAIN, ANTIBODY FAB FRAGMENT HEAVY CHAIN, ...
Authors:Brohawn, S.G.
Deposit date:2019-06-27
Release date:2019-12-25
Last modified:2020-10-21
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier.
Elife, 8, 2019
3HXR
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NUCLEOPORIN NUP120 FROM S.CEREVISIAE (AA 1-757)
Descriptor:Nucleoporin NUP120
Authors:Leksa, N.C., Brohawn, S.G., Schwartz, T.U.
Deposit date:2009-06-21
Release date:2009-07-28
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structure of the scaffold nucleoporin Nup120 reveals a new and unexpected domain architecture.
Structure, 17, 2009
6NZW
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LRRC8A-DCPIB IN MSP1E3D1 NANODISC CONSTRICTED STATE
Descriptor:Volume-regulated anion channel subunit LRRC8A, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}butanoic acid
Authors:Kern, D.M., Hite, R.K., Brohawn, S.G.
Deposit date:2019-02-14
Release date:2019-02-27
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs.
Elife, 8, 2019
6NZZ
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LRRC8A-DCPIB IN MSP1E3D1 NANODISC EXPANDED STATE
Descriptor:Volume-regulated anion channel subunit LRRC8A, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}butanoic acid
Authors:Kern, D.M., Hite, R.K., Brohawn, S.G.
Deposit date:2019-02-14
Release date:2019-02-27
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs.
Elife, 8, 2019
6O00
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APO-LRRC8A IN MSP2N2 NANODISC CONSTRICTED STATE
Descriptor:Volume-regulated anion channel subunit LRRC8A
Authors:Kern, D.M., Hite, R.K., Brohawn, S.G.
Deposit date:2019-02-14
Release date:2019-02-27
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.18 Å)
Cite:Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs.
Elife, 8, 2019
6UKN
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CRYO-EM STRUCTURE OF THE POTASSIUM-CHLORIDE COTRANSPORTER KCC4 IN LIPID NANODISCS
Descriptor:Solute carrier family 12 member 7, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, POTASSIUM ION, ...
Authors:Reid, M.S., Kern, D.M., Brohawn, S.G.
Deposit date:2019-10-05
Release date:2020-06-10
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.65 Å)
Cite:Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs.
Elife, 9, 2020
6WLV
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TASK2 IN MSP1D1 LIPID NANODISC AT PH 6.5
Descriptor:Potassium channel TASK2, POTASSIUM ION
Authors:Li, B., Brohawn, S.G.
Deposit date:2020-04-20
Release date:2020-07-15
Last modified:2020-10-28
Method:ELECTRON MICROSCOPY (3.45 Å)
Cite:Structural basis for pH gating of the two-pore domain K + channel TASK2.
Nature, 586, 2020
6WM0
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TASK2 IN MSP1D1 LIPID NANODISC AT PH 8.5
Descriptor:Potassium channel TASK2, POTASSIUM ION
Authors:Li, B., Brohawn, S.G.
Deposit date:2020-04-20
Release date:2020-07-15
Last modified:2020-10-28
Method:ELECTRON MICROSCOPY (3.52 Å)
Cite:Structural basis for pH gating of the two-pore domain K + channel TASK2.
Nature, 586, 2020
6XDC
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CRYO-EM STRUCTURE OF SARS-COV-2 ORF3A
Descriptor:Protein 3a
Authors:Kern, D.M., Hoel, C.M., Brohawn, S.G.
Deposit date:2020-06-10
Release date:2020-06-17
Last modified:2020-07-08
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Cryo-EM structure of the SARS-CoV-2 3a ion channel in lipid nanodiscs.
Biorxiv, 2020
7KJR
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CRYO-EM STRUCTURE OF SARS-COV-2 ORF3A
Descriptor:Protein 3a, Apolipoprotein A-I, 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
Authors:Kern, D.M., Hoel, C.M., Kotecha, A., Brohawn, S.G.
Deposit date:2020-10-26
Release date:2020-11-18
Method:ELECTRON MICROSCOPY (2.08 Å)
Cite:Cryo-EM structure of the SARS-CoV-2 3a ion channel in lipid nanodiscs.
Biorxiv, 2020
2GED
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SIGNAL RECOGNITION PARTICLE RECEPTOR BETA-SUBUNIT IN NUCLEOTIDE-FREE DIMERIZED FORM
Descriptor:Signal recognition particle receptor beta subunit, SULFATE ION
Authors:Schmidt, D., Schwartz, T.U.
Deposit date:2006-03-19
Release date:2006-04-18
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Homodimerization of the G protein SR{beta} in the nucleotide-free state involves proline cis/trans isomerization in the switch II region.
Proc.Natl.Acad.Sci.USA, 103, 2006
171588
PDB entries from 2020-11-25