Author results

3DFR
  • Download 3dfr
  • View 3dfr
Molmil generated image of 3dfr
CRYSTAL STRUCTURES OF ESCHERICHIA COLI AND LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE REFINED AT 1.7 ANGSTROMS RESOLUTION. I. GENERAL FEATURES AND BINDING OF METHOTREXATE
Descriptor:DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, METHOTREXATE
Authors:Filman, D.J., Matthews, D.A., Bolin, J.T., Kraut, J.
Deposit date:1982-06-25
Release date:1982-10-21
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate.
J.Biol.Chem., 257, 1982
4DFR
  • Download 4dfr
  • View 4dfr
Molmil generated image of 4dfr
CRYSTAL STRUCTURES OF ESCHERICHIA COLI AND LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE REFINED AT 1.7 ANGSTROMS RESOLUTION. I. GENERAL FEATURES AND BINDING OF METHOTREXATE
Descriptor:DIHYDROFOLATE REDUCTASE, CHLORIDE ION, METHOTREXATE, ...
Authors:Filman, D.J., Matthews, D.A., Bolin, J.T., Kraut, J.
Deposit date:1982-06-25
Release date:1982-10-21
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate.
J.Biol.Chem., 257, 1982
5DFR
  • Download 5dfr
  • View 5dfr
Molmil generated image of 5dfr
CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING
Descriptor:DIHYDROFOLATE REDUCTASE, CHLORIDE ION
Authors:Bystroff, C., Kraut, J.
Deposit date:1988-10-21
Release date:1990-07-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of unliganded Escherichia coli dihydrofolate reductase. Ligand-induced conformational changes and cooperativity in binding.
Biochemistry, 30, 1991
6DFR
  • Download 6dfr
  • View 6dfr
Molmil generated image of 6dfr
CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. THE NADP+ HOLOENZYME AND THE FOLATE(DOT)NADP+ TERNARY COMPLEX. SUBSTRATE BINDING AND A MODEL FOR THE TRANSITION STATE
Descriptor:DIHYDROFOLATE REDUCTASE, CALCIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Bystroff, C., Oatley, S.J., Kraut, J.
Deposit date:1988-10-21
Release date:1990-07-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of Escherichia coli dihydrofolate reductase: the NADP+ holoenzyme and the folate.NADP+ ternary complex. Substrate binding and a model for the transition state.
Biochemistry, 29, 1990
7DFR
  • Download 7dfr
  • View 7dfr
Molmil generated image of 7dfr
CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. THE NADP+ HOLOENZYME AND THE FOLATE(DOT)NADP+ TERNARY COMPLEX. SUBSTRATE BINDING AND A MODEL FOR THE TRANSITION STATE
Descriptor:DIHYDROFOLATE REDUCTASE, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Bystroff, C., Oatley, S.J., Kraut, J.
Deposit date:1988-10-21
Release date:1990-07-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of Escherichia coli dihydrofolate reductase: the NADP+ holoenzyme and the folate.NADP+ ternary complex. Substrate binding and a model for the transition state.
Biochemistry, 29, 1990
8DFR
  • Download 8dfr
  • View 8dfr
Molmil generated image of 8dfr
REFINED CRYSTAL STRUCTURES OF CHICKEN LIVER DIHYDROFOLATE REDUCTASE. 3 ANGSTROMS APO-ENZYME AND 1.7 ANGSTROMS NADPH HOLO-ENZYME COMPLEX
Descriptor:DIHYDROFOLATE REDUCTASE, CALCIUM ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Matthews, D.A., Oatley, S.J., Burridge, J., Kaufman, B.T., Xuong, N.-H., Kraut, J.
Deposit date:1989-05-30
Release date:1989-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Refined Crystal Structures of Chicken Liver Dihydrofolate Reductase. 3 Angstroms Apo-Enzyme and 1.7 Angstroms Nadph Holo-Enzyme Complex
To be Published
1DRA
  • Download 1dra
  • View 1dra
Molmil generated image of 1dra
CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING
Descriptor:DIHYDROFOLATE REDUCTASE, CHLORIDE ION, METHOTREXATE, ...
Authors:Oatley, S.J., Kraut, J.
Deposit date:1991-11-06
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of unliganded Escherichia coli dihydrofolate reductase. Ligand-induced conformational changes and cooperativity in binding.
Biochemistry, 30, 1991
1DRB
  • Download 1drb
  • View 1drb
Molmil generated image of 1drb
CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING
Descriptor:DIHYDROFOLATE REDUCTASE, CHLORIDE ION, METHOTREXATE, ...
Authors:David, C., Kraut, J.
Deposit date:1991-11-06
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Crystal structure of unliganded Escherichia coli dihydrofolate reductase. Ligand-induced conformational changes and cooperativity in binding.
Biochemistry, 30, 1991
1DR1
  • Download 1dr1
  • View 1dr1
Molmil generated image of 1dr1
2.2 ANGSTROMS CRYSTAL STRUCTURE OF CHICKEN LIVER DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADP+ AND BIOPTERIN
Descriptor:DIHYDROFOLATE REDUCTASE, CALCIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Mctigue, M.A., Davies /II, J.F., Kaufman, B.T., Xuong, N.-H., Kraut, J.
Deposit date:1992-03-14
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of chicken liver dihydrofolate reductase complexed with NADP+ and biopterin.
Biochemistry, 31, 1992
1DR2
  • Download 1dr2
  • View 1dr2
Molmil generated image of 1dr2
2.3 ANGSTROMS CRYSTAL STRUCTURE OF CHICKEN LIVER DIHYDROFOLATE REDUCTASE COMPLEXED WITH THIONADP+ AND BIOPTERIN
Descriptor:DIHYDROFOLATE REDUCTASE, CALCIUM ION, 7-THIONICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Mctigue, M.A., Davies /II, J.F., Kaufman, B.T., Xuong, N.-H., Kraut, J.
Deposit date:1992-03-14
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of chicken liver dihydrofolate reductase: binary thioNADP+ and ternary thioNADP+.biopterin complexes.
Biochemistry, 32, 1993
1DR3
  • Download 1dr3
  • View 1dr3
Molmil generated image of 1dr3
2.3 ANGSTROMS CRYSTAL STRUCTURE OF CHICKEN LIVER DIHYDROFOLATE REDUCTASE COMPLEXED WITH THIONADP+ AND BIOPTERIN
Descriptor:DIHYDROFOLATE REDUCTASE, CALCIUM ION, 7-THIONICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Mctigue, M.A., Davies /II, J.F., Kaufman, B.T., Xuong, N.-H., Kraut, J.
Deposit date:1992-03-14
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of chicken liver dihydrofolate reductase: binary thioNADP+ and ternary thioNADP+.biopterin complexes.
Biochemistry, 32, 1993
1DR4
  • Download 1dr4
  • View 1dr4
Molmil generated image of 1dr4
CRYSTAL STRUCTURES OF ORGANOMERCURIAL-ACTIVATED CHICKEN LIVER DIHYDROFOLATE REDUCTASE COMPLEXES
Descriptor:DIHYDROFOLATE REDUCTASE, MERCURY (II) ION, CALCIUM ION, ...
Authors:Mctigue, M.A., Davies /II, J.F., Kaufman, B.T., Xuong, N.-H., Kraut, J.
Deposit date:1992-03-14
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures of Organomercurial-Activated Chicken Liver Dihydrofolate Reductase Complexes
To be Published
1DR5
  • Download 1dr5
  • View 1dr5
Molmil generated image of 1dr5
CRYSTAL STRUCTURES OF ORGANOMERCURIAL-ACTIVATED CHICKEN LIVER DIHYDROFOLATE REDUCTASE COMPLEXES
Descriptor:DIHYDROFOLATE REDUCTASE, MERCURY (II) ION, CALCIUM ION, ...
Authors:Mctigue, M.A., Davies /II, J.F., Kaufman, B.T., Xuong, N.-H., Kraut, J.
Deposit date:1992-03-14
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures of Organomercurial-Activated Chicken Liver Dihydrofolate Reductase Complexes
To be Published
1DR6
  • Download 1dr6
  • View 1dr6
Molmil generated image of 1dr6
CRYSTAL STRUCTURES OF ORGANOMERCURIAL-ACTIVATED CHICKEN LIVER DIHYDROFOLATE REDUCTASE COMPLEXES
Descriptor:DIHYDROFOLATE REDUCTASE, CALCIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Mctigue, M.A., Davies /II, J.F., Kaufman, B.T., Xuong, N.-H., Kraut, J.
Deposit date:1992-03-14
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures of Organomercurial-Activated Chicken Liver Dihydrofolate Reductase Complexes
To be Published
1DR7
  • Download 1dr7
  • View 1dr7
Molmil generated image of 1dr7
CRYSTAL STRUCTURES OF ORGANOMERCURIAL-ACTIVATED CHICKEN LIVER DIHYDROFOLATE REDUCTASE COMPLEXES
Descriptor:DIHYDROFOLATE REDUCTASE, CALCIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Mctigue, M.A., Davies /II, J.F., Kaufman, B.T., Xuong, N.-H., Kraut, J.
Deposit date:1992-03-14
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures of Organomercurial-Activated Chicken Liver Dihydrofolate Reductase Complexes
To be Published
2DRC
  • Download 2drc
  • View 2drc
Molmil generated image of 2drc
INVESTIGATION OF THE FUNCTIONAL ROLE OF TRYPTOPHAN-22 IN ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE BY SITE-DIRECTED MUTAGENESIS
Descriptor:DIHYDROFOLATE REDUCTASE, CHLORIDE ION, METHOTREXATE, ...
Authors:Brown, K.A., Kraut, J.
Deposit date:1992-06-10
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Investigation of the functional role of tryptophan-22 in Escherichia coli dihydrofolate reductase by site-directed mutagenesis.
Biochemistry, 30, 1991
3DRC
  • Download 3drc
  • View 3drc
Molmil generated image of 3drc
INVESTIGATION OF THE FUNCTIONAL ROLE OF TRYPTOPHAN-22 IN ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE BY SITE-DIRECTED MUTAGENESIS
Descriptor:DIHYDROFOLATE REDUCTASE, CHLORIDE ION, METHOTREXATE, ...
Authors:Oatley, S.J., Kraut, J.
Deposit date:1992-09-22
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Investigation of the functional role of tryptophan-22 in Escherichia coli dihydrofolate reductase by site-directed mutagenesis.
Biochemistry, 30, 1991
1DHI
  • Download 1dhi
  • View 1dhi
Molmil generated image of 1dhi
LONG-RANGE STRUCTURAL EFFECTS IN A SECOND-SITE REVERTANT OF A MUTANT DIHYDROFOLATE REDUCTASE
Descriptor:DIHYDROFOLATE REDUCTASE, CHLORIDE ION, METHOTREXATE, ...
Authors:Oatley, S.J., Villafranca, J.E., Brown, K.A., Kraut, J.
Deposit date:1993-10-29
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Long-range structural effects in a second-site revertant of a mutant dihydrofolate reductase.
Proc.Natl.Acad.Sci.USA, 90, 1993
1DHJ
  • Download 1dhj
  • View 1dhj
Molmil generated image of 1dhj
LONG-RANGE STRUCTURAL EFFECTS IN A SECOND-SITE REVERTANT OF A MUTANT DIHYDROFOLATE REDUCTASE
Descriptor:DIHYDROFOLATE REDUCTASE, CHLORIDE ION, METHOTREXATE, ...
Authors:Brown, K.A., Kraut, J.
Deposit date:1993-10-29
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Long-range structural effects in a second-site revertant of a mutant dihydrofolate reductase.
Proc.Natl.Acad.Sci.USA, 90, 1993
1DYH
  • Download 1dyh
  • View 1dyh
Molmil generated image of 1dyh
ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5-DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS
Descriptor:DIHYDROFOLATE REDUCTASE, CHLORIDE ION, 5-DEAZAFOLIC ACID, ...
Authors:Reyes, V.M., Kraut, J.
Deposit date:1994-10-26
Release date:1995-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications.
Biochemistry, 34, 1995
1DYI
  • Download 1dyi
  • View 1dyi
Molmil generated image of 1dyi
ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5-DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS
Descriptor:DIHYDROFOLATE REDUCTASE, CHLORIDE ION, FOLIC ACID, ...
Authors:Reyes, V.M., Kraut, J.
Deposit date:1994-10-26
Release date:1995-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications.
Biochemistry, 34, 1995
1DYJ
  • Download 1dyj
  • View 1dyj
Molmil generated image of 1dyj
ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5-DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS
Descriptor:DIHYDROFOLATE REDUCTASE, CHLORIDE ION, 5,10-DIDEAZATETRAHYDROFOLIC ACID, ...
Authors:Reyes, V.M., Kraut, J.
Deposit date:1994-10-26
Release date:1995-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications.
Biochemistry, 34, 1995
1DIS
  • Download 1dis
  • View 1dis
Molmil generated image of 1dis
DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEX WITH BRODIMOPRIM-4,6-DICARBOXYLATE
Descriptor:DIHYDROFOLATE REDUCTASE, BRODIMOPRIM-4,6-DICARBOXYLATE
Authors:Morgan, W.D., Birdsall, B., Polshakov, V.I., Sali, D., Kompis, I., Feeney, J.
Deposit date:1995-08-01
Release date:1995-11-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of a brodimoprim analogue in its complex with Lactobacillus casei dihydrofolate reductase.
Biochemistry, 34, 1995
1DIU
  • Download 1diu
  • View 1diu
Molmil generated image of 1diu
DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEX WITH BRODIMOPRIM-4,6-DICARBOXYLATE
Descriptor:DIHYDROFOLATE REDUCTASE, BRODIMOPRIM-4,6-DICARBOXYLATE
Authors:Morgan, W.D., Birdsall, B., Polshakov, V.I., Sali, D., Kompis, I., Feeney, J.
Deposit date:1995-08-01
Release date:1995-11-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of a brodimoprim analogue in its complex with Lactobacillus casei dihydrofolate reductase.
Biochemistry, 34, 1995
1HAN
  • Download 1han
  • View 1han
Molmil generated image of 1han
CRYSTAL STRUCTURE OF THE BIPHENYL-CLEAVING EXTRADIOL DIOXYGENASE FROM A PCB-DEGRADING PSEUDOMONAD
Descriptor:2,3-DIHYDROXYBIPHENYL 1,2-DIOXYGENASE, FE (III) ION, TERTIARY-BUTYL ALCOHOL
Authors:Han, S., Bolin, J.T.
Deposit date:1995-08-30
Release date:1995-11-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the biphenyl-cleaving extradiol dioxygenase from a PCB-degrading pseudomonad.
Science, 270, 1995