Author results

6P6F
  • Download 6p6f
  • View 6p6f
Molmil generated image of 6p6f
BG505 SOSIP-I53-50NP
Descriptor:I53-50A.1NT1, I53-50B.4PT1
Authors:Berndsen, Z.T., Ward, A.B.
Deposit date:2019-06-03
Release date:2019-06-19
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers by presentation on a two-component protein nanoparticle
To be Published
6MRR
  • Download 6mrr
  • View 6mrr
Molmil generated image of 6mrr
DE NOVO DESIGNED PROTEIN FOLDIT1
Descriptor:Foldit1
Authors:Koepnick, B., Bick, M.J., Estep, R.D., Kleinfelter, S., Wei, L., Baker, D.
Deposit date:2018-10-15
Release date:2019-06-12
Last modified:2019-06-26
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:De novo protein design by citizen scientists.
Nature, 570, 2019
6MRS
  • Download 6mrs
  • View 6mrs
Molmil generated image of 6mrs
DE NOVO DESIGNED PROTEIN PEAK6
Descriptor:Peak6, SULFATE ION
Authors:Koepnick, B., Boykov, A., Baker, D.
Deposit date:2018-10-15
Release date:2019-06-12
Last modified:2019-06-26
Method:X-RAY DIFFRACTION (1.541 Å)
Cite:De novo protein design by citizen scientists.
Nature, 570, 2019
6MSP
  • Download 6msp
  • View 6msp
Molmil generated image of 6msp
DE NOVO DESIGNED PROTEIN FOLDIT3
Descriptor:De novo Designed Protein Foldit3
Authors:Liu, G., Ishida, Y., Swapna, G.V.T., Kleinfelter, S., Koepnick, B., Baker, D., Montelione, G.T.
Deposit date:2018-10-17
Release date:2019-06-12
Last modified:2019-06-19
Method:SOLUTION NMR
Cite:De novo protein design by citizen scientists.
Nature, 2019
6NUK
  • Download 6nuk
  • View 6nuk
Molmil generated image of 6nuk
DE NOVO DESIGNED PROTEIN FERREDOG-DIESEL
Descriptor:Ferredog-Diesel
Authors:Koepnick, B., Bick, M.J., DiMaio, F., Norgard-Solano, T., Baker, D.
Deposit date:2019-02-01
Release date:2019-06-12
Last modified:2019-06-19
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:De novo protein design by citizen scientists.
Nature, 2019
6MOE
  • Download 6moe
  • View 6moe
Molmil generated image of 6moe
MONOMERIC DARPIN E2 COMPLEX WITH EPOR
Descriptor:E2 DARPin, Erythropoietin receptor, PHOSPHATE ION, ...
Authors:Jude, K.M., Mohan, K., Garcia, K.C.
Deposit date:2018-10-04
Release date:2019-06-05
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (2.091 Å)
Cite:Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
6MOF
  • Download 6mof
  • View 6mof
Molmil generated image of 6mof
MONOMERIC DARPIN G2 COMPLEX WITH EPOR
Descriptor:G2 DARPin, Erythropoietin receptor, 1,2-ETHANEDIOL
Authors:Jude, K.M., Mohan, K., Garcia, K.C.
Deposit date:2018-10-04
Release date:2019-06-05
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (2.894 Å)
Cite:Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
6MOG
  • Download 6mog
  • View 6mog
Molmil generated image of 6mog
DIMERIC DARPIN C_R3
Descriptor:DARPin C_R3, 1,2-ETHANEDIOL, TRIETHYLENE GLYCOL
Authors:Jude, K.M., Mohan, K., Garcia, K.C.
Deposit date:2018-10-04
Release date:2019-06-05
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (1.21 Å)
Cite:Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
6MOH
  • Download 6moh
  • View 6moh
Molmil generated image of 6moh
DIMERIC DARPIN C_R3 COMPLEX WITH EPOR
Descriptor:Dimeric DARPin E2C (C_R3), Erythropoietin receptor, PHOSPHATE ION, ...
Authors:Jude, K.M., Mohan, K., Garcia, K.C.
Deposit date:2018-10-04
Release date:2019-06-05
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
6MOI
  • Download 6moi
  • View 6moi
Molmil generated image of 6moi
DIMERIC DARPIN C_ANGLE_R5 COMPLEX WITH EPOR
Descriptor:Dimeric DARPing CCR5 (C_angle_R5), Erythropoietin receptor, SULFATE ION, ...
Authors:Jude, K.M., Mohan, K., Garcia, K.C., Guo, Y.
Deposit date:2018-10-04
Release date:2019-06-05
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (2.065 Å)
Cite:Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
6MOJ
  • Download 6moj
  • View 6moj
Molmil generated image of 6moj
DIMERIC DARPIN A_ANGLE_R5 COMPLEX WITH EPOR
Descriptor:Dimeric DARPin ACR5 (A_angle_R5), Erythropoietin receptor, D(-)-TARTARIC ACID, ...
Authors:Jude, K.M., Mohan, K., Garcia, K.C.
Deposit date:2018-10-04
Release date:2019-06-05
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (2.431 Å)
Cite:Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
6MOK
  • Download 6mok
  • View 6mok
Molmil generated image of 6mok
DIMERIC DARPIN ANR7 COMPLEX WITH EPOR
Descriptor:Dimeric DARPin ANR7 (A_distance_r7), Erythropoietin receptor
Authors:Jude, K.M., Mohan, K., Garcia, K.C., Guo, Y.
Deposit date:2018-10-04
Release date:2019-06-05
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (5.101 Å)
Cite:Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
6MOL
  • Download 6mol
  • View 6mol
Molmil generated image of 6mol
MONOEXTENDED DARPIN M_R12 COMPLEX WITH EPOR
Descriptor:Monoextended DARPin R12 (M_R12), Erythropoietin receptor, GLYCEROL
Authors:Jude, K.M., Mohan, K., Garcia, K.C., Guo, Y.
Deposit date:2018-10-04
Release date:2019-06-05
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (3.163 Å)
Cite:Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
6EGC
  • Download 6egc
  • View 6egc
Molmil generated image of 6egc
SINGLE-CHAIN VERSION OF 2L4HC2_23 (PDB 5J0K)
Descriptor:SC_2L4HC2_23
Authors:Bick, M.J., Chen, Z., DiMaio, F.
Deposit date:2018-08-19
Release date:2019-05-29
Last modified:2019-06-26
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Self-Assembling 2D Arrays with de Novo Protein Building Blocks.
J.Am.Chem.Soc., 141, 2019
6NDZ
  • Download 6ndz
  • View 6ndz
Molmil generated image of 6ndz
DESIGNED REPEAT PROTEIN IN COMPLEX WITH FZ8
Descriptor:Frizzled-8, Designed repeat binding protein, (4S)-2-METHYL-2,4-PENTANEDIOL, ...
Authors:Miao, Y., Jude, K.M., Garcia, K.C.
Deposit date:2018-12-14
Release date:2019-05-15
Last modified:2019-06-19
Method:X-RAY DIFFRACTION (2.264 Å)
Cite:Receptor subtype discrimination using extensive shape complementary designed interfaces.
Nat.Struct.Mol.Biol., 26, 2019
6NE1
  • Download 6ne1
  • View 6ne1
Molmil generated image of 6ne1
DESIGNED REPEAT PROTEIN IN COMPLEX WITH FZ4
Descriptor:Frizzled-4, Pfs, NACHT and Ankyrin domain protein, ...
Authors:Miao, Y., Jude, K.M., Garcia, K.C.
Deposit date:2018-12-15
Release date:2019-05-15
Last modified:2019-06-19
Method:X-RAY DIFFRACTION (3.011 Å)
Cite:Receptor subtype discrimination using extensive shape complementary designed interfaces.
Nat.Struct.Mol.Biol., 26, 2019
6NE2
  • Download 6ne2
  • View 6ne2
Molmil generated image of 6ne2
DESIGNED REPEAT PROTEIN IN COMPLEX WITH FZ7
Descriptor:Designed repeat protein binder, Frizzled-7, ACETATE ION, ...
Authors:Miao, Y., Jude, K.M., Garcia, K.C.
Deposit date:2018-12-15
Release date:2019-05-15
Last modified:2019-06-19
Method:X-RAY DIFFRACTION (1.299 Å)
Cite:Receptor subtype discrimination using extensive shape complementary designed interfaces.
Nat.Struct.Mol.Biol., 26, 2019
6NE4
  • Download 6ne4
  • View 6ne4
Molmil generated image of 6ne4
DESIGNED REPEAT PROTEIN SPECIFICALLY IN COMPLEX WITH FZ7CRD
Descriptor:Designed repeat binding protein, Frizzled-7, SULFATE ION, ...
Authors:Miao, Y., Jude, K.M., Garcia, K.C.
Deposit date:2018-12-16
Release date:2019-05-15
Last modified:2019-06-19
Method:X-RAY DIFFRACTION (1.648 Å)
Cite:Receptor subtype discrimination using extensive shape complementary designed interfaces.
Nat.Struct.Mol.Biol., 26, 2019
6MSQ
  • Download 6msq
  • View 6msq
Molmil generated image of 6msq
CRYSTAL STRUCTURE OF PRO-2.3
Descriptor:pRO-2.3
Authors:Boyken, S.E., Bick, M.J., Baker, D.
Deposit date:2018-10-17
Release date:2019-05-08
Last modified:2019-05-29
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:De novo design of tunable, pH-driven conformational changes.
Science, 364, 2019
6MSR
  • Download 6msr
  • View 6msr
Molmil generated image of 6msr
CRYSTAL STRUCTURE OF PRO-2.5
Descriptor:pRO-2.5
Authors:Bick, M.J., Boyken, S.E., Baker, D.
Deposit date:2018-10-17
Release date:2019-05-08
Last modified:2019-05-29
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:De novo design of tunable, pH-driven conformational changes.
Science, 364, 2019
6Q38
  • Download 6q38
  • View 6q38
Molmil generated image of 6q38
THE CRYSTAL STRUCTURE OF CK2A BOUND TO P1-C4
Descriptor:Casein kinase II subunit alpha, Stapled Peptide, BENZOIC ACID
Authors:Brear, P., Iegre, J., Baker, D., Tan, Y., Sore, H., Donovan, D., Spring, D., Chandra, V., Hyvonen, M.
Deposit date:2018-12-03
Release date:2019-04-24
Last modified:2019-06-19
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Efficient development of stable and highly functionalised peptides targeting the CK2 alpha /CK2 beta protein-protein interaction.
Chem Sci, 10, 2019
6Q4Q
  • Download 6q4q
  • View 6q4q
Molmil generated image of 6q4q
THE CRYSTAL STRUCTURE OF CK2A BOUND TO P2-C4
Descriptor:Casein kinase II subunit alpha, Stapled peptide, GLYCEROL, ...
Authors:Brear, P., Iegre, J., Baker, D., Tan, Y., Sore, H., Donovan, D., Spring, D., Chandra, V., Hyvonen, M.
Deposit date:2018-12-06
Release date:2019-04-24
Last modified:2019-06-19
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Efficient development of stable and highly functionalised peptides targeting the CK2 alpha /CK2 beta protein-protein interaction.
Chem Sci, 10, 2019
6DG5
  • Download 6dg5
  • View 6dg5
Molmil generated image of 6dg5
STRUCTURE OF A DE NOVO DESIGNED INTERLEUKIN-2/INTERLEUKIN-15 MIMETIC COMPLEX WITH IL-2RB AND IL-2RG
Descriptor:Neoleukin-2/15, Interleukin-2 receptor subunit beta, Cytokine receptor common subunit gamma, ...
Authors:Jude, K.M., Silva, D.-A., Yu, S., Baker, D., Garcia, K.C.
Deposit date:2018-05-16
Release date:2019-01-16
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (2.516 Å)
Cite:De novo design of potent and selective mimics of IL-2 and IL-15.
Nature, 565, 2019
6DG6
  • Download 6dg6
  • View 6dg6
Molmil generated image of 6dg6
STRUCTURE OF A DE NOVO DESIGNED INTERLEUKIN-2/INTERLEUKIN-15 MIMETIC
Descriptor:Neoleukin-2/15
Authors:Jude, K.M., Silva, D.-A., Yu, S., Baker, D., Garcia, K.C.
Deposit date:2018-05-16
Release date:2019-01-16
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:De novo design of potent and selective mimics of IL-2 and IL-15.
Nature, 565, 2019
6DLC
  • Download 6dlc
  • View 6dlc
Molmil generated image of 6dlc
DESIGNED PROTEIN DHD1:234_A, DESIGNED PROTEIN DHD1:234_B
Descriptor:Designed protein DHD1:234_A, Designed protein DHD1:234_B
Authors:Bick, M.J., Chen, Z., Baker, D.
Deposit date:2018-05-31
Release date:2018-12-26
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (3.261 Å)
Cite:Programmable design of orthogonal protein heterodimers.
Nature, 565, 2019