Author results

4V5H
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E.COLI 70S RIBOSOME STALLED DURING TRANSLATION OF TNAC LEADER PEPTIDE.
Descriptor:16S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S2, 30S RIBOSOMAL PROTEIN S3, ...
Authors:Seidelt, B., Innis, C.A., Wilson, D.N., Gartmann, M., Armache, J., Villa, E., Trabuco, L.G., Becker, T., Mielke, T., Schulten, K., Steitz, T.A., Beckmann, R.
Deposit date:2009-10-26
Release date:2014-07-09
Last modified:2018-04-18
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Structural insight into nascent polypeptide chain-mediated translational stalling.
Science, 326, 2009
4V7W
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STRUCTURE OF THE THERMUS THERMOPHILUS RIBOSOME COMPLEXED WITH CHLORAMPHENICOL.
Descriptor:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Bulkley, D.P., Innis, C.A., Blaha, G., Steitz, T.A.
Deposit date:2010-08-16
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Revisiting the structures of several antibiotics bound to the bacterial ribosome.
Proc.Natl.Acad.Sci.USA, 107, 2010
4V7X
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STRUCTURE OF THE THERMUS THERMOPHILUS RIBOSOME COMPLEXED WITH ERYTHROMYCIN.
Descriptor:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Bulkley, D.P., Innis, C.A., Blaha, G., Steitz, T.A.
Deposit date:2010-08-17
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Revisiting the structures of several antibiotics bound to the bacterial ribosome.
Proc.Natl.Acad.Sci.USA, 107, 2010
4V7Y
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STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME COMPLEXED WITH AZITHROMYCIN.
Descriptor:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Bulkley, D.P., Innis, C.A., Blaha, G., Steitz, T.A.
Deposit date:2010-08-18
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Revisiting the structures of several antibiotics bound to the bacterial ribosome.
Proc.Natl.Acad.Sci.USA, 107, 2010
4V7Z
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STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME COMPLEXED WITH TELITHROMYCIN.
Descriptor:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Bulkley, D.P., Innis, C.A., Blaha, G., Steitz, T.A.
Deposit date:2010-08-18
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Revisiting the structures of several antibiotics bound to the bacterial ribosome.
Proc.Natl.Acad.Sci.USA, 107, 2010
4V8A
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THE STRUCTURE OF THERMORUBIN IN COMPLEX WITH THE 70S RIBOSOME FROM THERMUS THERMOPHILUS.
Descriptor:23S ribosomal RNA, 5S ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Bulkley, D., Johnson, F.A., Steitz, T.A.
Deposit date:2011-12-05
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The antibiotic thermorubin inhibits protein synthesis by binding to inter-subunit bridge b2a of the ribosome.
J.Mol.Biol., 416, 2012
4V8G
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CRYSTAL STRUCTURE OF RMF BOUND TO THE 70S RIBOSOME.
Descriptor:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
Authors:Polikanov, Y.S., Blaha, G.M., Steitz, T.A.
Deposit date:2011-12-11
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:How hibernation factors RMF, HPF, and YfiA turn off protein synthesis.
Science, 336, 2012
4V8H
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CRYSTAL STRUCTURE OF HPF BOUND TO THE 70S RIBOSOME.
Descriptor:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
Authors:Polikanov, Y.S., Blaha, G.M., Steitz, T.A.
Deposit date:2011-12-11
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:How Hibernation Factors RMF, HPF, and YfiA Turn Off Protein Synthesis.
Science, 336, 2012
4V8I
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CRYSTAL STRUCTURE OF YFIA BOUND TO THE 70S RIBOSOME.
Descriptor:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
Authors:Polikanov, Y.S., Blaha, G.M., Steitz, T.A.
Deposit date:2011-12-12
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:How hibernation factors RMF, HPF, and YfiA turn off protein synthesis.
Science, 336, 2012
4V95
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CRYSTAL STRUCTURE OF YAEJ BOUND TO THE 70S RIBOSOME
Descriptor:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
Authors:Gagnon, M.G., Seetharaman, S.V., Bulkley, D.P., Steitz, T.A.
Deposit date:2012-01-27
Release date:2014-07-09
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for the rescue of stalled ribosomes: structure of YaeJ bound to the ribosome.
Science, 335, 2012
4V9R
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CRYSTAL STRUCTURE OF ANTIBIOTIC DITYROMYCIN BOUND TO 70S RIBOSOME
Descriptor:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
Authors:Bulkley, D.P., Brandi, L., Polikanov, Y.S., Fabbretti, A., O'Connor, M., Gualerzi, C.O., Steitz, T.A.
Deposit date:2013-12-05
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:The antibiotics dityromycin and GE82832 bind protein S12 and block EF-G-catalyzed translocation.
Cell Rep, 6, 2014
4V9S
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CRYSTAL STRUCTURE OF ANTIBIOTIC GE82832 BOUND TO 70S RIBOSOME
Descriptor:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
Authors:Bulkley, D.P., Brandi, L., Polikanov, Y.S., Fabbretti, A., O'Connor, M., Gualerzi, C.O., Steitz, T.A.
Deposit date:2013-12-05
Release date:2014-07-09
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The antibiotics dityromycin and GE82832 bind protein S12 and block EF-G-catalyzed translocation.
Cell Rep, 6, 2014
4W2E
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CRYSTAL STRUCTURE OF ELONGATION FACTOR 4 (EF4/LEPA) BOUND TO THE THERMUS THERMOPHILUS 70S RIBOSOME
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Gagnon, M.G., Lin, J., Steitz, T.A.
Deposit date:2014-06-04
Release date:2014-10-01
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of elongation factor 4 bound to a clockwise ratcheted ribosome.
Science, 345, 2014
4W2I
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH NEGAMYCIN, MRNA AND THREE DEACYLATED TRNAS IN THE A, P AND E SITES
Descriptor:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
Authors:Polikanov, Y.S., Szal, T., Jiang, F., Gupta, P., Matsuda, R., Shiozuka, M., Steitz, T.A., Vazquez-Laslop, N., Mankin, A.S.
Deposit date:2014-09-12
Release date:2014-10-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Negamycin Interferes with Decoding and Translocation by Simultaneous Interaction with rRNA and tRNA.
Mol.Cell, 56, 2014
4WPO
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH ELONGATION FACTOR G IN THE PRE-TRANSLOCATIONAL STATE
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L1, ...
Authors:Lin, J., Gagnon, M.G., Steitz, T.A.
Deposit date:2014-10-20
Release date:2015-01-28
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Conformational Changes of Elongation Factor G on the Ribosome during tRNA Translocation.
Cell, 160, 2015
4WQF
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH ELONGATION FACTOR G AND FUSIDIC ACID IN THE POST-TRANSLOCATIONAL STATE
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L1, ...
Authors:Lin, J., Gagnon, M.G., Steitz, T.A.
Deposit date:2014-10-21
Release date:2015-01-28
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Conformational Changes of Elongation Factor G on the Ribosome during tRNA Translocation.
Cell, 160, 2015
4WQU
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH ELONGATION FACTOR G TRAPPED BY THE ANTIBIOTIC DITYROMYCIN
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L1, ...
Authors:Lin, J., Gagnon, M.G., Steitz, T.A.
Deposit date:2014-10-22
Release date:2015-01-28
Last modified:2016-05-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Conformational Changes of Elongation Factor G on the Ribosome during tRNA Translocation.
Cell, 160, 2015
4WQY
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH ELONGATION FACTOR G IN THE POST-TRANSLOCATIONAL STATE (WITHOUT FUSITIC ACID)
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L1, ...
Authors:Lin, J., Gagnon, M.G., Steitz, T.A.
Deposit date:2014-10-22
Release date:2015-01-28
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Conformational Changes of Elongation Factor G on the Ribosome during tRNA Translocation.
Cell, 160, 2015
4Y4O
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME WITH RRNA MODIFICATIONS AND BOUND TO PROTEIN Y (YFIA) AT 2.3A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Polikanov, Y.S., Melnikov, S.V., Soll, D., Steitz, T.A.
Deposit date:2015-02-10
Release date:2015-03-18
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly.
Nat.Struct.Mol.Biol., 22, 2015
4Y4P
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME WITH RRNA MODIFICATIONS AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.5A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Polikanov, Y.S., Melnikov, S.V., Soll, D., Steitz, T.A.
Deposit date:2015-02-10
Release date:2015-03-18
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly.
Nat.Struct.Mol.Biol., 22, 2015
4YLN
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E. COLI TRANSCRIPTION INITIATION COMPLEX - 17-BP SPACER AND 4-NT RNA
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Zuo, Y., Steitz, T.A.
Deposit date:2015-03-05
Release date:2015-04-22
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (5.5 Å)
Cite:Crystal Structures of the E. coli Transcription Initiation Complexes with a Complete Bubble.
Mol.Cell, 58, 2015
4YLO
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E. COLI TRANSCRIPTION INITIATION COMPLEX - 16-BP SPACER AND 4-NT RNA
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Zuo, Y., Steitz, T.A.
Deposit date:2015-03-05
Release date:2015-04-22
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (6 Å)
Cite:Crystal Structures of the E. coli Transcription Initiation Complexes with a Complete Bubble.
Mol.Cell, 58, 2015
4YLP
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E. COLI TRANSCRIPTION INITIATION COMPLEX - 16-BP SPACER AND 5-NT RNA
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Zuo, Y., Steitz, T.A.
Deposit date:2015-03-05
Release date:2015-04-22
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (5.5 Å)
Cite:Crystal Structures of the E. coli Transcription Initiation Complexes with a Complete Bubble.
Mol.Cell, 58, 2015
4Z3S
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH ANTIBIOTIC A201A, MRNA AND THREE TRNAS IN THE A, P AND E SITES AT 2.65A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Polikanov, Y.S., Starosta, A.L., Juette, M.F., Altman, R.B., Terry, D.S., Lu, W., Burnett, B.J., Dinos, G., Reynolds, K., Blanchard, S.C., Steitz, T.A., Wilson, D.N.
Deposit date:2015-03-31
Release date:2015-06-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.
Mol.Cell, 58, 2015
4Z8C
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME BOUND TO TRANSLATION INHIBITOR ONCOCIN
Descriptor:23S ribosomal RNA, 5S ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Roy, R.N., Lomakin, I.B., Gagnon, M.G., Steitz, T.A.
Deposit date:2015-04-08
Release date:2015-05-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The mechanism of inhibition of protein synthesis by the proline-rich peptide oncocin.
Nat.Struct.Mol.Biol., 22, 2015