Author results

4M8N
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CRYSTAL STRUCTURE OF PLEXINC1/RAP1B COMPLEX
分子名称:PlexinC1 Intracellular Region, Ras-related protein Rap-1b, MAGNESIUM ION, ...
著者Pascoe, H.G., Wang, Y., Brautigam, C.A., He, H., Zhang, X.
登録日2013-08-13
公開日2013-10-09
最終更新日2014-01-15
実験手法X-RAY DIFFRACTION (3.294 Å)
主引用文献Structural basis for activation and non-canonical catalysis of the Rap GTPase activating protein domain of plexin.
Elife, 2, 2013
4P5M
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STRUCTURAL BASIS OF CHRONIC BERYLLIUM DISEASE: BRIDGING THE GAP BETWEEN ALLERGIC HYPERSENSITIVITY AND AUTOIMMUNITY
分子名称:HLA class II histocompatibility antigen, DP alpha 1 chain, peptide,HLA class II histocompatibility antigen, ...
著者Wang, Y., Dai, S., Kappler, J.
登録日2014-03-18
公開日2014-08-27
最終更新日2015-10-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity.
Cell, 158, 2014
4PES
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CRYSTAL STRUCTURE OF INSULIN DEGRADING ENZYME COMPLEXED WITH INHIBITOR TERT-BUTYL [(2S)-2-(2,5-DIFLUOROPHENYL)-3-(QUINOLIN-3-YL)PROPYL]CARBAMATE
分子名称:Insulin-degrading enzyme, Ala-Ala-Ala, tert-butyl [(2S)-2-(2,5-difluorophenyl)-3-(quinolin-3-yl)propyl]carbamate, ...
著者Wang, Y., Guo, S.
登録日2014-04-24
公開日2015-06-17
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Crystal structure of IDE complexed with an inhibitor
To Be Published
4PF7
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CRYSTAL STRUCTURE OF INSULIN DEGRADING ENZYME COMPLEXED WITH INHIBITOR
分子名称:Insulin-degrading enzyme, (2S)-2-amino-N-{(1S)-1-cyclohexyl-2-[(4-methylphenyl)amino]-2-oxoethyl}-4-(methylselanyl)butanamide, ZINC ION
著者Wang, Y., Guo, S.
登録日2014-04-28
公開日2015-06-17
最終更新日2015-08-26
実験手法X-RAY DIFFRACTION (2.33 Å)
主引用文献Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.
J.Biol.Chem., 290, 2015
4PF9
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CRYSTAL STRUCTURE OF INSULIN DEGRADING ENZYME COMPLEXED WITH INHIBITOR
分子名称:Insulin-degrading enzyme, methyl [(2S)-2-[4-({5-[4-({(2S)-2-[(3S)-3-amino-2-oxopiperidin-1-yl]-2-cyclohexylacetyl}amino)phenyl]pentyl}oxy)phenyl]-3-(quinolin-3-yl)propyl]carbamate, ZINC ION
著者Wang, Y., Guo, S.
登録日2014-04-28
公開日2015-06-17
最終更新日2015-08-26
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.
J.Biol.Chem., 290, 2015
4PFC
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CRYSTAL STRUCTURE OF INSULIN DEGRADING ENZYME COMPLEXED WITH INHIBITOR
分子名称:Insulin-degrading enzyme, methyl [(2S)-2-(5-{5-[4-({(2S)-2-[(3S)-3-amino-2-oxopiperidin-1-yl]-2-cyclohexylacetyl}amino)phenyl]pentyl}-2-fluorophenyl)-3-(quinolin-3-yl)propyl]carbamate, ZINC ION
著者Wang, Y., Guo, S.
登録日2014-04-28
公開日2015-06-17
最終更新日2015-08-26
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.
J.Biol.Chem., 290, 2015
4PFJ
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THE STRUCTURE OF BI-ACETYLATED SAHH
分子名称:Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ADENOSINE
著者Kavran, J.M., Wang, Y., Cole, P.A., Leahy, D.J.
登録日2014-04-29
公開日2014-10-01
最終更新日2018-01-17
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Regulation of s-adenosylhomocysteine hydrolase by lysine acetylation.
J.Biol.Chem., 289, 2014
4PGF
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THE STRUCTURE OF MONO-ACETYLATED SAHH
分子名称:Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ADENOSINE
著者Kavran, J.M., Wang, Y., Cole, P.A., Leahy, D.J.
登録日2014-05-01
公開日2014-10-01
最終更新日2018-01-17
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Regulation of s-adenosylhomocysteine hydrolase by lysine acetylation.
J.Biol.Chem., 289, 2014
5DMK
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CRYSTAL STRUCTURE OF IAG7 IN COMPLEX WITH RLGL-WE14
分子名称:H-2 class II histocompatibility antigen, A-D alpha chain, beta chain of Major Histocompatibility Complex Class II, ...
著者Wang, Y., Jin, N., Dai, S., Kappler, J.W.
登録日2015-09-08
公開日2015-10-28
最終更新日2016-04-06
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献N-terminal additions to the WE14 peptide of chromogranin A create strong autoantigen agonists in type 1 diabetes.
Proc.Natl.Acad.Sci.USA, 112, 2015
5G4C
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HUMAN SIRT2 CATALYSE SHORT CHAIN FATTY ACYL LYSINE
分子名称:NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2, SIRT2, ZINC ION, ...
著者Wang, Y.
登録日2016-05-09
公開日2017-05-03
最終更新日2019-04-24
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献SIRT2 Reverses 4-Oxononanoyl Lysine Modification on Histones.
J. Am. Chem. Soc., 138, 2016
5IY4
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CRYSTAL STRUCTURE OF HUMAN PCNA IN COMPLEX WITH THE PIP BOX OF DVC1
分子名称:Proliferating cell nuclear antigen, DVC1 PIP box
著者Jiang, T., Xu, M., Wang, Y.
登録日2016-03-24
公開日2016-06-08
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (2.945 Å)
主引用文献Crystal structure of human PCNA in complex with the PIP box of DVC1
Biochem.Biophys.Res.Commun., 474, 2016
5K13
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CRYSTAL STRUCTURE OF THE RAR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH AN ANTAGONIST
分子名称:Retinoic acid receptor alpha, 4-{5-(3-tert-butylphenyl)-1-[4-(methylsulfonyl)phenyl]-1H-pyrazol-3-yl}benzoic acid
著者Wang, Y., Stout, S.L.
登録日2016-05-17
公開日2016-06-22
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Identification of potent and selective retinoic acid receptor gamma (RAR gamma ) antagonists for the treatment of osteoarthritis pain using structure based drug design.
Bioorg.Med.Chem.Lett., 26, 2016
5V39
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CRYSTAL STRUCTURE OF HUMAN VITAMIN D RECEPTOR LIGAND BINDING DOMAIN IN COMPLEX WITH A VDRM
分子名称:Vitamin D3 receptor, 5-(3-{4-[(2S)-2-hydroxy-3,3-dimethylbutoxy]-3-methylphenyl}pentan-3-yl)-3-methyl-N-(1H-tetrazol-5-yl)thiophene-2-carboxamide
著者Wang, Y., Pelletier, L.
登録日2017-03-06
公開日2018-03-14
最終更新日2019-04-03
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions.
Nat Commun, 8, 2017
6CCY
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CRYSTAL STRUCTURE OF AKT1 IN COMPLEX WITH A SELECTIVE INHIBITOR
分子名称:RAC-alpha serine/threonine-protein kinase,PIFtide, (5R)-4-(4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[2-(pyrrolidin-1-yl)ethyl]-1H-imidazol-2-yl}piperidin-1-yl)-5-methyl-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one
著者Wang, Y., Stout, S.
登録日2018-02-07
公開日2018-05-02
最終更新日2018-05-16
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT.
Bioorg. Med. Chem. Lett., 28, 2018
6ISO
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HUMAN SIRT3 RECOGNIZING H3K4CR
分子名称:NAD-dependent protein deacetylase sirtuin-3, mitochondrial, ARG-THR-LYS-GLN-THR-ALA-ARG, ...
著者Wang, Y., Hao, Q.
登録日2018-11-17
公開日2019-01-23
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Identification of 'erasers' for lysine crotonylated histone marks using a chemical proteomics approach.
Elife, 3, 2014
6NOD
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CRYSTAL STRUCTURE OF C. ELEGANS PUF-8 IN COMPLEX WITH RNA
分子名称:PUF (Pumilio/FBF) domain-containing, RNA (5'-R(P*UP*GP*UP*AP*UP*AP*UP*A)-3')
著者Wang, Y., McCann, K.L., Qiu, C., Hall, T.M.T.
登録日2019-01-16
公開日2019-01-30
実験手法X-RAY DIFFRACTION (2.547 Å)
主引用文献Engineering a conserved RNA regulatory protein repurposes its biological functionin vivo.
Elife, 8, 2019
4KOL
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THE STRUCTURE OF HEMAGGLUTININ FROM AVIAN-ORIGIN H7N9 INFLUENZA VIRUS
分子名称:Hemagglutinin HA1, Hemagglutinin HA2, N-ACETYL-D-GLUCOSAMINE
著者Shi, Y., Zhang, W., Wang, F., Qi, J., Song, H., Wu, Y., Gao, F., Zhang, Y., Fan, Z., Gong, W., Wang, D., Shu, Y., Wang, Y., Yan, J., Gao, G.F.
登録日2013-05-12
公開日2013-11-06
実験手法X-RAY DIFFRACTION (2.799 Å)
主引用文献Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses.
Science, 342, 2013
4KOM
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THE STRUCTURE OF HEMAGGLUTININ FROM AVIAN-ORIGIN H7N9 INFLUENZA VIRUS IN COMPLEX WITH AVIAN RECEPTOR ANALOG 3'SLNLN (NEUACα2-3GALβ1-4GLCNACβ1-3GALβ1-4GLC)
分子名称:Hemagglutinin HA1, Hemagglutinin HA2, N-ACETYL-D-GLUCOSAMINE, ...
著者Shi, Y., Zhang, W., Wang, F., Qi, J., Song, H., Wu, Y., Gao, F., Zhang, Y., Fan, Z., Gong, W., Wang, D., Shu, Y., Wang, Y., Yan, J., Gao, G.F.
登録日2013-05-12
公開日2013-11-06
実験手法X-RAY DIFFRACTION (2.604 Å)
主引用文献Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses.
Science, 342, 2013
4KON
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THE STRUCTURE OF HEMAGGLUTININ FROM AVIAN-ORIGIN H7N9 INFLUENZA VIRUS IN COMPLEX WITH HUMAN RECEPTOR ANALOG 6'SLNLN (NEUACα2-6GALβ1-4GLCNACβ1-3GALβ1-4GLC)
分子名称:Hemagglutinin HA1, Hemagglutinin HA2, N-ACETYL-D-GLUCOSAMINE, ...
著者Shi, Y., Zhang, W., Wang, F., Qi, J., Song, H., Wu, Y., Gao, F., Zhang, Y., Fan, Z., Gong, W., Wang, D., Shu, Y., Wang, Y., Yan, J., Gao, G.F.
登録日2013-05-12
公開日2013-11-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses.
Science, 342, 2013
4LCX
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THE STRUCTURE OF HEMAGGLUTININ FROM AVIAN-ORIGIN H7N9 INFLUENZA VIRUS (A/SHANGHAI/1/2013)
分子名称:Hemagglutinin HA1, Hemagglutinin HA2, N-ACETYL-D-GLUCOSAMINE
著者Shi, Y., Zhang, W., Wang, F., Qi, J., Song, H., Wu, Y., Gao, F., Zhang, Y., Fan, Z., Gong, W., Wang, D., Shu, Y., Wang, Y., Yan, J., Gao, G.F.
登録日2013-06-24
公開日2013-11-06
実験手法X-RAY DIFFRACTION (3.094 Å)
主引用文献Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses.
Science, 342, 2013
4LKG
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THE STRUCTURE OF HEMAGGLUTININ FROM A AVIAN-ORIGIN H7N9 INFLUENZA VIRUS (A/SHANGHAI/1/2013) IN COMPLEX WITH AVIAN RECEPTOR ANALOG 3'SLNLN
分子名称:hemagglutinin, O-SIALIC ACID, BETA-D-GALACTOSE, ...
著者Shi, Y., Zhang, W., Wang, F., Qi, J., Song, H., Wu, Y., Gao, F., Zhang, Y., Fan, Z., Gong, W., Wang, D., Shu, Y., Wang, Y., Yan, J., Gao, G.F.
登録日2013-07-07
公開日2013-11-06
実験手法X-RAY DIFFRACTION (2.994 Å)
主引用文献Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses
Science, 342, 2013
4LKH
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THE STRUCTURE OF HEMAGGLUTININ FROM A AVIAN-ORIGIN H7N9 INFLUENZA VIRUS (A/SHANGHAI/1/2013) IN COMPLEX WITH HUMAN RECEPTOR ANALOG 6'SLNLN
分子名称:hemagglutinin, N-ACETYL-D-GLUCOSAMINE, O-SIALIC ACID
著者Shi, Y., Zhang, W., Wang, F., Qi, J., Song, H., Wu, Y., Gao, F., Zhang, Y., Fan, Z., Gong, W., Wang, D., Shu, Y., Wang, Y., Yan, J., Gao, G.F.
登録日2013-07-07
公開日2013-11-06
実験手法X-RAY DIFFRACTION (3.099 Å)
主引用文献Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses
Science, 342, 2013
4LKI
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THE STRUCTURE OF HEMAGGLUTININ L226Q MUTANT FROM A AVIAN-ORIGIN H7N9 INFLUENZA VIRUS (A/ANHUI/1/2013)
分子名称:hemagglutinin, N-ACETYL-D-GLUCOSAMINE
著者Shi, Y., Zhang, W., Wang, F., Qi, J., Song, H., Wu, Y., Gao, F., Zhang, Y., Fan, Z., Gong, W., Wang, D., Shu, Y., Wang, Y., Yan, J., Gao, G.F.
登録日2013-07-07
公開日2013-11-06
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses
Science, 342, 2013
4LKJ
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THE STRUCTURE OF HEMAGGLUTININ L226Q MUTANT (H3 NUMBERING) FROM A AVIAN-ORIGIN H7N9 INFLUENZA VIRUS (A/ANHUI/1/2013) IN COMPLEX WITH AVIAN RECEPTOR ANALOG 3'SLNLN
分子名称:hemagglutinin, N-ACETYL-D-GLUCOSAMINE, O-SIALIC ACID, ...
著者Shi, Y., Zhang, W., Wang, F., Qi, J., Song, H., Wu, Y., Gao, F., Zhang, Y., Fan, Z., Gong, W., Wang, D., Shu, Y., Wang, Y., Yan, J., Gao, G.F.
登録日2013-07-07
公開日2013-11-06
実験手法X-RAY DIFFRACTION (2.798 Å)
主引用文献Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses
Science, 342, 2013
4LKK
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THE STRUCTURE OF HEMAGGLUTININ L226Q MUTANT (H3 NUMBERING) FROM A AVIAN-ORIGIN H7N9 INFLUENZA VIRUS (A/ANHUI/1/2013) IN COMPLEX WITH HUMAN RECEPTOR ANALOG 6'SLNLN
分子名称:hemagglutinin, N-ACETYL-D-GLUCOSAMINE, O-SIALIC ACID, ...
著者Shi, Y., Zhang, W., Wang, F., Qi, J., Song, H., Wu, Y., Gao, F., Zhang, Y., Fan, Z., Gong, W., Wang, D., Shu, Y., Wang, Y., Yan, J., Gao, G.F.
登録日2013-07-07
公開日2013-11-06
実験手法X-RAY DIFFRACTION (2.491 Å)
主引用文献Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses
Science, 342, 2013