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2PW6
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CRYSTAL STRUCTURE OF UNCHARACTERIZED PROTEIN JW3007 FROM ESCHERICHIA COLI K12
Descriptor:Uncharacterized protein ygiD, ZINC ION
Authors:Newton, M.G., Takagi, Y., Ebihara, A., Shinkai, A., Kuramitsu, S., Yokayama, S., Li, Y., Chen, L., Zhu, J., Ruble, J., Liu, Z.J., Rose, J.P., Wang, B.-C., Southeast Collaboratory for Structural Genomics (SECSG), RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-05-10
Release date:2007-06-12
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Crystal structure of uncharacterized protein JW3007 from Escherichia coli K12.
To be Published
2VC2
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RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO ANTAGONIST L-739758
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-09-18
Release date:2008-09-02
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDK
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RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDL
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RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDM
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RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO ANTAGONIST TIROFIBAN
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDN
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RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO ANTAGONIST EPTIFIBATIDE
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, EPTIFIBATIDE, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDO
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INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO FIBRINOGEN GAMMA CHAIN PEPTIDE, HHLGGAKQAGDV
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, FIBRINOGEN, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDP
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INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO FIBRINOGEN GAMMA CHAIN PEPTIDE,LGGAKQAGDV
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, FIBRINOGEN, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDQ
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INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO A CHIMERIC FIBRINOGEN GAMMA CHAIN PEPTIDE, HHLGGAKQRGDV
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, FIBRINOGEN, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDR
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INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO A CHIMERIC FIBRINOGEN GAMMA CHAIN PEPTIDE, LGGAKQRGDV
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, FIBRINOGEN, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
3DBC
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CRYSTAL STRUCTURE OF AN ACTIVATED (THR->ASP) POLO-LIKE KINASE 1 (PLK1) CATALYTIC DOMAIN IN COMPLEX WITH COMPOUND 257
Descriptor:Polo-like kinase 1, 3-[3-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]propanamide
Authors:Elling, R.A., Zhu, J., Barr, K.J., Romanowski, M.J.
Deposit date:2008-05-31
Release date:2008-10-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors.
Bioorg.Med.Chem.Lett., 18, 2008
3DBF
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CRYSTAL STRUCTURE OF AN ACTIVATED (THR->ASP) POLO-LIKE KINASE 1 (PLK1) CATALYTIC DOMAIN IN COMPLEX WITH COMPOUND 562
Descriptor:Polo-like kinase, 4-({1-[3-(3-amino-3-oxopropyl)-5-chlorophenyl]-3-methyl-1H-pyrazolo[4,3-c]pyridin-6-yl}amino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
Authors:Elling, R.A., Zhu, J., Barr, K.J., Romanowski, M.J.
Deposit date:2008-05-31
Release date:2008-10-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors.
Bioorg.Med.Chem.Lett., 18, 2008
3H3B
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CRYSTAL STRUCTURE OF THE SINGLE-CHAIN FV (SCFV) FRAGMENT OF AN ANTI-ERBB2 ANTIBODY CHA21 IN COMPLEX WITH RESIDUES 1-192 OF ERBB2 EXTRACELLULAR DOMAIN
Descriptor:Receptor tyrosine-protein kinase erbB-2, anti-ErbB2 antibody chA21
Authors:Zhou, H., Liu, Y., Niu, L., Zhu, J., Teng, M.
Deposit date:2009-04-16
Release date:2010-04-28
Last modified:2011-09-28
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural Insights into the Down-regulation of Overexpressed p185her2/neu Protein of Transformed Cells by the Antibody chA21.
J.Biol.Chem., 286, 2011
3K6S
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STRUCTURE OF INTEGRIN ALPHAXBETA2 ECTODOMAIN
Descriptor:Integrin alpha-X, Integrin beta-2, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Xie, C., Zhu, J., Chen, X., Mi, L., Nishida, N., Springer, T.A.
Deposit date:2009-10-09
Release date:2010-01-12
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure of an integrin with an alphaI domain, complement receptor type 4.
Embo J., 29, 2010
3K71
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STRUCTURE OF INTEGRIN ALPHAX BETA2 ECTODOMAIN
Descriptor:Integrin alpha-X, Integrin beta-2, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Xie, C., Zhu, J., Chen, X., Mi, L., Nishida, N., Springer, T.A.
Deposit date:2009-10-11
Release date:2010-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.95 Å)
Cite:Structure of an integrin with an alphaI domain, complement receptor type 4.
Embo J., 29, 2010
3K72
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STRUCTURE OF INTEGRIN ALPHAX BETA2
Descriptor:Integrin alpha-X, Integrin beta-2, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Xie, C., Zhu, J., Chen, X., Mi, L., Nishida, N., Springer, T.A.
Deposit date:2009-10-11
Release date:2010-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Structure of an integrin with an alphaI domain, complement receptor type 4.
Embo J., 29, 2010
3MME
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STRUCTURE AND FUNCTIONAL DISSECTION OF PG16, AN ANTIBODY WITH BROAD AND POTENT NEUTRALIZATION OF HIV-1
Descriptor:PG16 HEAVY CHAIN FAB, PG16 LIGHT CHAIN FAB, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Pancera, M., McLellan, J., Zhou, T., Zhu, J., Kwong, P.
Deposit date:2010-04-19
Release date:2010-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.97 Å)
Cite:Crystal structure of PG16 and chimeric dissection with somatically related PG9: structure-function analysis of two quaternary-specific antibodies that effectively neutralize HIV-1.
J.Virol., 84, 2010
3V4P
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CRYSTAL STRUCTURE OF A4B7 HEADPIECE COMPLEXED WITH FAB ACT-1
Descriptor:Integrin alpha-4, Integrin beta-7, MONOCLONAL ANTIBODY Act-1 HEAVY CHAIN, ...
Authors:Yu, Y., Zhu, J., Springer, T.A.
Deposit date:2011-12-15
Release date:2012-01-11
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structural specializations of a4b7, an Integrin that Mediates Rolling Adhesion
J.Cell Biol., 196, 2012
3V4V
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CRYSTAL STRUCTURE OF A4B7 HEADPIECE COMPLEXED WITH FAB ACT-1 AND RO0505376
Descriptor:Integrin alpha-4, Integrin beta-7, MONOCLONAL ANTIBODY Act-1 HEAVY CHAIN, ...
Authors:Yu, Y., Zhu, J., Springer, T.A.
Deposit date:2011-12-15
Release date:2012-01-11
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural specializations of a4b7, an Integrin that Mediates Rolling Adhesion
J.Cell Biol., 196, 2012
4G5O
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STRUCTURE OF LGN GL4/GALPHAI3(Q147L) COMPLEX
Descriptor:Guanine nucleotide-binding protein G(k) subunit alpha, G-protein-signaling modulator 2, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Jia, M., Li, J., Zhu, J., Wen, W., Zhang, M., Wang, W.
Deposit date:2012-07-18
Release date:2012-09-05
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structures of the scaffolding protein LGN reveal the general mechanism by which GoLoco binding motifs inhibit the release of GDP from Galphai subunits in G-coupled heterotrimeric proteins
To be Published
4G5Q
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STRUCTURE OF LGN GL4/GALPHAI1 COMPLEX
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, G-protein-signaling modulator 2, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Jia, M., Li, J., Zhu, J., Wen, W., Zhang, M., Wang, W.
Deposit date:2012-07-18
Release date:2012-09-05
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structures of the scaffolding protein LGN reveal the general mechanism by which GoLoco binding motifs inhibit the release of GDP from Galphai subunits in G-coupled heterotrimeric proteins
To be Published
4G5R
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STRUCTURE OF LGN GL4/GALPHAI3 COMPLEX
Descriptor:Guanine nucleotide-binding protein G(k) subunit alpha, G-protein-signaling modulator 2, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Jia, M., Li, J., Zhu, J., Wen, W., Zhang, M., Wang, W.
Deposit date:2012-07-18
Release date:2012-09-05
Method:X-RAY DIFFRACTION (3.481 Å)
Cite:Crystal Structures of the scaffolding protein LGN reveal the general mechanism by which GoLoco binding motifs inhibit the release of GDP from Galphai subunits in G-coupled heterotrimeric proteins
To be Published
4H6J
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IDENTIFICATION OF CYS 255 IN HIF-1 AS A NOVEL SITE FOR DEVELOPMENT OF COVALENT INHIBITORS OF HIF-1 /ARNT PASB DOMAIN PROTEIN-PROTEIN INTERACTION.
Descriptor:HYPOXIA INDUCIBLE FACTOR 1-ALPHA, ARYL HYDROCARBON NUCLEAR TRANSLOCATOR
Authors:Cardoso, R., Love, R.A., Nilsson, C., Bergqvist, S., Nowlin, D., Yan, J., Liu, K., Zhu, J., Chen, P., Deng, Y.-L., Dyson, H.J., Greig, M.J., Brooun, A.
Deposit date:2012-09-19
Release date:2012-12-05
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Identification of Cys255 in HIF-1 alpha as a novel site for development of covalent inhibitors of HIF-1 alpha /ARNT PasB domain protein-protein interaction.
Protein Sci., 21, 2012
4HJW
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CRYSTAL STRUCTURE OF METARHIZIUM ANISOPLIAE IDCASE IN APO FORM
Descriptor:Uracil-5-carboxylate decarboxylase, ZINC ION
Authors:Xu, S., Zhu, J., Ding, J.
Deposit date:2012-10-14
Release date:2013-09-11
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase.
Cell Res., 23, 2013
4HK5
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CRYSTAL STRUCTURE OF CORDYCEPS MILITARIS IDCASE IN APO FORM
Descriptor:Uracil-5-carboxylate decarboxylase, ZINC ION
Authors:Xu, S., Zhu, J., Ding, J.
Deposit date:2012-10-15
Release date:2013-09-11
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase.
Cell Res., 23, 2013