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4M0U
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CRYSTAL STRUCTURE OF HUMAN PRS1 Q133P MUTANT
Descriptor:Ribose-phosphate pyrophosphokinase 1, SULFATE ION
Authors:Chen, P., Teng, M., Li, X.
Deposit date:2013-08-02
Release date:2015-02-04
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations
Plos One, 10, 2015
4QSG
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CRYSTAL STRUCTURE OF GAS VESICLE PROTEIN GVPF FROM MICROCYSTIS AERUGINOSA
Descriptor:Gas vesicle protein
Authors:Xu, B.Y., Dai, Y.N., Zhou, K., Ren, Y.M., Liu, Y.T., Chen, Y., Zhou, C.Z.
Deposit date:2014-07-03
Release date:2014-11-12
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of the gas vesicle protein GvpF from the cyanobacterium Microcystis aeruginosa
Acta Crystallogr.,Sect.D, 70, 2014
5GTB
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CRYSTAL STRUCTURE OF INTERMEMBRANE SPACE REGION OF THE ARC6-PDV2 COMPLEX
Descriptor:Protein ACCUMULATION AND REPLICATION OF CHLOROPLASTS 6, chloroplastic, Plastid division protein PDV2
Authors:Feng, Y., Wang, W.
Deposit date:2016-08-19
Release date:2017-03-01
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (2.871 Å)
Cite:Structural insights into the coordination of plastid division by the ARC6-PDV2 complex
Nat Plants, 3, 2017
5HAD
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CRYSTAL STRUCTURE OF INTERMEMBRANE SPACE REGION OF CHLOROPLAST PROTEIN ARC6
Descriptor:Protein ACCUMULATION AND REPLICATION OF CHLOROPLASTS 6, chloroplastic, 1,2-ETHANEDIOL
Authors:Feng, Y., Yu, X.
Deposit date:2015-12-30
Release date:2017-01-18
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.238 Å)
Cite:Structural insights into the coordination of plastid division by the ARC6-PDV2 complex
Nat Plants, 3, 2017
5IC7
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STRUCTURE OF THE WD DOMAIN OF UTP18
Descriptor:Putative uncharacterized protein, SULFATE ION
Authors:Zhang, C., Ye, K.
Deposit date:2016-02-22
Release date:2016-07-06
Last modified:2016-09-14
Method:X-RAY DIFFRACTION (2.331 Å)
Cite:Integrative structural analysis of the UTPB complex, an early assembly factor for eukaryotic small ribosomal subunits
Nucleic Acids Res., 44, 2016
5IC8
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STRUCTURE OF UTP6
Descriptor:Putative uncharacterized protein
Authors:Zhang, C., Ye, K.
Deposit date:2016-02-23
Release date:2016-07-06
Last modified:2016-09-14
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Integrative structural analysis of the UTPB complex, an early assembly factor for eukaryotic small ribosomal subunits
Nucleic Acids Res., 44, 2016
5IC9
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STRUCTURE OF THE CTD COMPLEX OF UTP12 AND UTP13
Descriptor:Putative uncharacterized protein
Authors:Zhang, C., Ye, K.
Deposit date:2016-02-23
Release date:2016-07-06
Last modified:2016-09-14
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Integrative structural analysis of the UTPB complex, an early assembly factor for eukaryotic small ribosomal subunits
Nucleic Acids Res., 44, 2016
5ICA
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STRUCTURE OF THE CTD COMPLEX OF UTP12, UTP13, UTP1 AND UTP21
Descriptor:Putative uncharacterized protein, Putative U3 snoRNP protein, Periodic tryptophan protein 2-like protein
Authors:Zhang, C., Ye, K.
Deposit date:2016-02-23
Release date:2016-07-06
Last modified:2016-09-14
Method:X-RAY DIFFRACTION (3.507 Å)
Cite:Integrative structural analysis of the UTPB complex, an early assembly factor for eukaryotic small ribosomal subunits
Nucleic Acids Res., 44, 2016
5JLJ
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CRYSTAL STRUCTURE OF KPT8602 IN COMPLEX WITH CRM1-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Fung, H.Y., Chook, Y.M.
Deposit date:2016-04-27
Release date:2016-06-29
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies.
Leukemia, 30, 2016
6D9X
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DISCOVERY OF POTENT 2-ARYL-6,7-DIHYDRO-5HPYRROLO[ 1,2-A]IMIDAZOLES AS WDR5 WIN-SITE INHIBITORS USING FRAGMENT-BASED METHODS AND STRUCTURE-BASED DESIGN
Descriptor:WD repeat-containing protein 5, SODIUM ION, 2-phenyl-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole
Authors:Phan, J., Fesik, S.W.
Deposit date:2018-04-30
Release date:2018-09-05
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design.
J. Med. Chem., 61, 2018
6DAI
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DISCOVERY OF POTENT 2-ARYL-6,7-DIHYDRO-5HPYRROLO[ 1,2-A]IMIDAZOLES AS WDR5 WIN-SITE INHIBITORS USING FRAGMENT-BASED METHODS AND STRUCTURE-BASED DESIGN
Descriptor:WD repeat-containing protein 5, DIMETHYL SULFOXIDE, 6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-1-methylindoline
Authors:Phan, J., Fesik, S.W.
Deposit date:2018-05-01
Release date:2018-09-05
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design.
J. Med. Chem., 61, 2018
6DAK
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DISCOVERY OF POTENT 2-ARYL-6,7-DIHYDRO-5HPYRROLO[ 1,2-A]IMIDAZOLES AS WDR5 WIN-SITE INHIBITORS USING FRAGMENT-BASED METHODS AND STRUCTURE-BASED DESIGN
Descriptor:WD repeat-containing protein 5, N-{[3-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)phenyl]methyl}benzamide, DIMETHYL SULFOXIDE
Authors:Phan, J., Fesik, S.W.
Deposit date:2018-05-01
Release date:2018-09-05
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design.
J. Med. Chem., 61, 2018
6DAR
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DISCOVERY OF POTENT 2-ARYL-6,7-DIHYDRO-5HPYRROLO[ 1,2-A]IMIDAZOLES AS WDR5 WIN-SITE INHIBITORS USING FRAGMENT-BASED METHODS AND STRUCTURE-BASED DESIGN
Descriptor:WD repeat-containing protein 5, N-(cyclopropylmethyl)-N-{[3-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)phenyl]methyl}-3-methoxybenzamide, SULFATE ION, ...
Authors:Phan, J., Fesik, S.W.
Deposit date:2018-05-01
Release date:2018-09-05
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design.
J. Med. Chem., 61, 2018
6DAS
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DISCOVERY OF POTENT 2-ARYL-6,7-DIHYDRO-5HPYRROLO[ 1,2-A]IMIDAZOLES AS WDR5 WIN-SITE INHIBITORS USING FRAGMENT-BASED METHODS AND STRUCTURE-BASED DESIGN
Descriptor:WD repeat-containing protein 5, N-[(1R)-6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl]-3-methoxy-4-methylbenzamide
Authors:Phan, J., Fesik, S.W.
Deposit date:2018-05-01
Release date:2018-07-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design.
J. Med. Chem., 61, 2018
6NM7
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PD-L1 IGV DOMAIN BOUND TO FRAGMENT
Descriptor:Programmed cell death 1 ligand 1, 5-phenylthieno[2,3-d]pyrimidin-4(3H)-one
Authors:Perry, E., Zhao, B.
Deposit date:2019-01-10
Release date:2019-02-20
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (2.426 Å)
Cite:Fragment-based screening of programmed death ligand 1 (PD-L1).
Bioorg. Med. Chem. Lett., 29, 2019
6NM8
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IGV-V76T BMS COMPOUND 105
Descriptor:Programmed cell death 1 ligand 1, N-({2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl}methyl)-D-alanine
Authors:Perry, E., Zhao, B., Fesik, S.
Deposit date:2019-01-10
Release date:2019-02-20
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (2.792 Å)
Cite:Fragment-based screening of programmed death ligand 1 (PD-L1).
Bioorg. Med. Chem. Lett., 29, 2019
6NNV
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PD-L1 IGV DOMAIN COMPLEX WITH MACRO-CYCLIC PEPTIDE
Descriptor:Programmed cell death 1 ligand 1, macrocyclic peptide
Authors:Zhao, B., Perry, E.
Deposit date:2019-01-15
Release date:2019-02-20
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Fragment-based screening of programmed death ligand 1 (PD-L1).
Bioorg. Med. Chem. Lett., 29, 2019
6NOJ
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PD-L1 IGV DOMAIN V76T WITH FRAGMENT
Descriptor:Programmed cell death 1 ligand 1, methyl 3-amino-4-(2-fluorophenyl)-1H-pyrrole-2-carboxylate
Authors:Zhao, B., Perry, E.
Deposit date:2019-01-16
Release date:2019-02-20
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Fragment-based screening of programmed death ligand 1 (PD-L1).
Bioorg. Med. Chem. Lett., 29, 2019
6NOS
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PD-L1 IGV DOMAIN V76T WITH FRAGMENT
Descriptor:Programmed cell death 1 ligand 1, 1-[5-(3,5-dichlorophenyl)furan-2-yl]-N-methylmethanamine
Authors:Zhao, B., Perry, E.
Deposit date:2019-01-16
Release date:2019-02-20
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.701 Å)
Cite:Fragment-based screening of programmed death ligand 1 (PD-L1).
Bioorg. Med. Chem. Lett., 29, 2019
6NP9
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PD-L1 IGV DOMAIN V76T WITH FRAGMENT
Descriptor:Programmed cell death 1 ligand 1, SULFATE ION
Authors:Zhao, B., Perry, E.
Deposit date:2019-01-17
Release date:2019-02-20
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (1.27 Å)
Cite:Fragment-based screening of programmed death ligand 1 (PD-L1).
Bioorg. Med. Chem. Lett., 29, 2019
1EGA
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CRYSTAL STRUCTURE OF A WIDELY CONSERVED GTPASE ERA
Descriptor:PROTEIN (GTP-BINDING PROTEIN ERA), SULFATE ION
Authors:Chen, X., Ji, X.
Deposit date:1998-12-01
Release date:1999-07-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of ERA: a GTPase-dependent cell cycle regulator containing an RNA binding motif.
Proc.Natl.Acad.Sci.USA, 96, 1999
5C7V
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MALATE SYNTHASE IN COMPLEX WITH 1H-PYRROLE-2-CARBOXYLIC ACID
Descriptor:Malate synthase G, MAGNESIUM ION, PYRROLE-2-CARBOXYLATE
Authors:Huang, H.-L., Sacchettini, J.C.
Deposit date:2015-06-25
Release date:2016-08-10
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.504 Å)
Cite:Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange.
J. Biol. Chem., 291, 2016
5C9R
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MALATE SYNTHASE IN COMPLEX WITH 3-((4-CHLOROPHENYL)THIO)PROPANOIC ACID
Descriptor:Malate synthase G, MAGNESIUM ION, 3-[(4-chlorophenyl)sulfanyl]propanoic acid
Authors:Huang, H.-L., Sacchettini, J.C.
Deposit date:2015-06-28
Release date:2016-07-27
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange.
J. Biol. Chem., 291, 2016
5C9U
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MALATE SYNTHASE IN COMPLEX WITH 2-(2-(2,4-DICHLOROPHENYL)HYDRAZINYL)-2-OXOACETIC ACID
Descriptor:Malate synthase G, MAGNESIUM ION, [2-(2,4-dichlorophenyl)hydrazinyl](oxo)acetic acid
Authors:Huang, H.-L., Sacchettini, J.C.
Deposit date:2015-06-29
Release date:2016-08-10
Last modified:2017-01-11
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange.
J. Biol. Chem., 291, 2016
5C9W
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MALATE SYNTHASE IN COMPLEX WITH (Z)-N-(2-BROMOPHENYL)-2-(HYDROXYIMINO)ACETAMIDE
Descriptor:Malate synthase G, MAGNESIUM ION, (2E)-N-(2-bromophenyl)-2-(hydroxyimino)acetamide
Authors:Huang, H.-L., Sacchettini, J.C.
Deposit date:2015-06-29
Release date:2016-08-10
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.0928 Å)
Cite:Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange.
J. Biol. Chem., 291, 2016