Author results

2WO7
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ISOPENICILLIN N SYNTHASE WITH SUBSTRATE ANALOGUE L,L,D-ACD2AB (UNEXPOSED)
Descriptor:ISOPENICILLIN N SYNTHASE, FE (II) ION, DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-D-VINYLGLYCINE
Authors:Ge, W., Clifton, I.J., Adlington, R.M., Baldwin, J.E., Rutledge, P.J.
Deposit date:2009-07-22
Release date:2010-07-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystallographic Studies on the Binding of Selectively Deuterated Lld- and Lll-Substrate Epimers by Isopenicillin N Synthase.
Biochem.Biophys.Res.Commun., 398, 2010
2WPW
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TANDEM GNAT PROTEIN FROM THE CLAVULANIC ACID BIOSYNTHESIS PATHWAY (WITHOUT ACCOA)
Descriptor:ORF14, ACETYL COENZYME *A
Authors:Iqbal, A., Arunlanantham, H., McDonough, M.A., Chowdhury, R., Clifton, I.J.
Deposit date:2009-08-11
Release date:2009-12-29
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Crystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathway.
Proteins, 78, 2010
2WPX
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TANDEM GNAT PROTEIN FROM THE CLAVULANIC ACID BIOSYNTHESIS PATHWAY (WITH ACCOA)
Descriptor:ORF14, ACETYL COENZYME *A, GLYCEROL
Authors:Iqbal, A., Arunlanantham, H., McDonough, M.A., Chowdhury, R., Clifton, I.J.
Deposit date:2009-08-11
Release date:2009-12-29
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Crystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathway.
Proteins, 78, 2010
2WWJ
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STRUCTURE OF JMJD2A COMPLEXED WITH INHIBITOR 10A
Descriptor:LYSINE-SPECIFIC DEMETHYLASE 4A, NICKEL (II) ION, ZINC ION, ...
Authors:Rose, N.R., Clifton, I.J., Oppermann, U., McDonough, M.A., Schofield, C.J.
Deposit date:2009-10-23
Release date:2010-03-09
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.
J. Med. Chem., 53, 2010
2YC0
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FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH R-2-HYDROXYGLUTARATE
Descriptor:HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, FE (II) ION, (2R)-2-hydroxypentanedioic acid, ...
Authors:Chowdhury, R., Clifton, I.J., Schofield, C.J.
Deposit date:2011-03-10
Release date:2011-03-30
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
EMBO Rep., 12, 2011
2YDE
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FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH S-2-HYDROXYGLUTARATE
Descriptor:HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, FE (III) ION, (2S)-2-HYDROXYPENTANEDIOIC ACID, ...
Authors:Chowdhury, R., Clifton, I.J., Schofield, C.J.
Deposit date:2011-03-18
Release date:2011-03-30
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
EMBO Rep., 12, 2011
2YEP
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STRUCTURE OF AN N-TERMINAL NUCLEOPHILE (NTN) HYDROLASE, OAT2, IN COMPLEX WITH GLUTAMATE
Descriptor:GLUTAMATE N-ACETYLTRANSFERASE 2 ALPHA CHAIN, GLUTAMATE N-ACETYLTRANSFERASE 2 BETA CHAIN, GLUTAMIC ACID, ...
Authors:Chowdhury, R., Iqbal, A., Clifton, I.J., Schofield, C.J.
Deposit date:2011-03-29
Release date:2011-09-07
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and Biochemical Analyses Reveal How Ornithine Acetyl Transferase Binds Acidic and Basic Amino Acid Substrates.
Org.Biomol.Chem., 9, 2011
3OD4
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CRYSTAL STRUCTURE OF FACTOR INHIBITING HIF-1 ALPHA COMPLEXED WITH INHIBITOR
Descriptor:Hypoxia-inducible factor 1-alpha inhibitor, ZINC ION, 8-hydroxyquinoline-5-carboxylic acid, ...
Authors:King, O.N.F., Bashford-Rogers, R., Maloney, D.J., Jadhav, A., Heightman, T.D., Simeonov, A., Clifton, I.J., McDonough, M.A., Schofield, C.J.
Deposit date:2010-08-10
Release date:2011-07-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of Factor Inhibiting HIF-1 Alpha Complexed with Inhibitor
To be Published
3RVH
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CRYSTAL STRUCTURE OF JMJD2A COMPLEXED WITH INHIBITOR
Descriptor:Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ...
Authors:King, O.N.F., Maloney, D.J., Tumber, A., Rai, G., Jadhav, A., Clifton, I.J., Heightman, T.D., Simeonov, A., McDonough, M.A., Schofield, C.J.
Deposit date:2011-05-06
Release date:2012-05-09
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.251 Å)
Cite:Crystal Structure of JMJD2A Complexed with Inhibitor
To be Published
3ZKU
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ISOPENICILLIN N SYNTHASE WITH SUBSTRATE ANALOGUE AHCV
Descriptor:ISOPENICILLIN N SYNTHASE, FE (III) ION, N-[(5S)-5-amino-5-carboxypentanoyl]-L-homocysteyl-D-valine
Authors:Daruzzaman, A., Clifton, I.J., Rutledge, P.J.
Deposit date:2013-01-24
Release date:2013-02-06
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The Interaction of Isopenicillin N Synthase with Homologated Substrate Analogues Delta-(L-Alpha-Aminoadipoyl)-L-Homocysteinyl-D-Xaa Characterised by Protein Crystallography.
Chembiochem, 14, 2013
3ZKY
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ISOPENICILLIN N SYNTHASE WITH SUBSTRATE ANALOGUE AHCMC
Descriptor:ISOPENICILLIN N SYNTHASE, FE (III) ION, N-[(5S)-5-amino-5-carboxypentanoyl]-L-homocysteyl-S-methyl-D-cysteine, ...
Authors:Daruzzaman, A., Clifton, I.J., Rutledge, P.J.
Deposit date:2013-01-25
Release date:2013-03-20
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:The Interaction of Isopenicillin N Synthase with Homologated Substrate Analogues Delta-(L-Alpha-Aminoadipoyl)-L-Homocysteinyl-D-Xaa Characterised by Protein Crystallography.
Chembiochem, 14, 2013
4BB3
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ISOPENICILLIN N SYNTHASE WITH THE DIPEPTIDE SUBSTRATE ANALOGUE AHC
Descriptor:ISOPENICILLIN N SYNTHASE, FE (III) ION, (2S)-2-azanyl-6-oxidanylidene-6-[[(2S)-1-oxidanyl-1-oxidanylidene-4-sulfanyl-butan-2-yl]amino]hexanoic acid, ...
Authors:Daruzzaman, A., Clifton, I.J., Rutledge, P.J.
Deposit date:2012-09-19
Release date:2013-04-17
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The Crystal Structure of Isopenicillin N Synthase with a Dipeptide Substrate Analogue.
Arch.Biochem.Biophys., 530, 2013
4BU2
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60S RIBOSOMAL PROTEIN L27A HISTIDINE HYDROXYLASE (MINA53) IN COMPLEX WITH NI(II) AND 2-OXOGLUTARATE (2OG)
Descriptor:BIFUNCTIONAL LYSINE-SPECIFIC DEMETHYLASE AND HISTIDYL-HYDROXYLASE MINA, NICKEL (II) ION, 2-OXOGLUTARIC ACID, ...
Authors:Chowdhury, R., Clifton, I.J., McDonough, M.A., Ng, S.S., Pilka, E., Oppermann, U., Schofield, C.J.
Deposit date:2013-06-19
Release date:2014-05-14
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
4CCJ
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60S RIBOSOMAL PROTEIN L8 HISTIDINE HYDROXYLASE (NO66) IN APO FORM
Descriptor:BIFUNCTIONAL LYSINE-SPECIFIC DEMETHYLASE AND HISTIDYL-HYDROXYLASE NO66, 1,2-ETHANEDIOL
Authors:Chowdhury, R., Ge, W., Clifton, I.J., Schofield, C.J.
Deposit date:2013-10-23
Release date:2014-05-14
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
4CCK
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60S RIBOSOMAL PROTEIN L8 HISTIDINE HYDROXYLASE (NO66) IN COMPLEX WITH MN(II) AND N-OXALYLGLYCINE (NOG)
Descriptor:BIFUNCTIONAL LYSINE-SPECIFIC DEMETHYLASE AND HISTIDYL-HYDROXYLASE NO66, MANGANESE (II) ION, N-OXALYLGLYCINE, ...
Authors:Chowdhury, R., Ge, W., Clifton, I.J., Schofield, C.J.
Deposit date:2013-10-23
Release date:2014-05-14
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
5FQC
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CRYSTAL STRUCTURE OF THE METALLO-BETA-LACTAMASE VIM-2 WITH 2C
Descriptor:BETA-LACTAMASE, FORMIC ACID, ZINC ION, ...
Authors:Brem, J., Cain, R., McDonough, M.A., Clifton, I.J., Fishwick, C.W.G., Schofield, C.J.
Deposit date:2015-12-08
Release date:2016-08-17
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (1.449 Å)
Cite:Structural basis of metallo-beta-lactamase, serine-beta-lactamase and penicillin-binding protein inhibition by cyclic boronates.
Nat Commun, 7, 2016
5J4R
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WELO5 SMALL MOLECULE HALOGENASE WITH NI(II) AND 2-OXOGLUTARATE
Descriptor:WelO5, 2-OXOGLUTARIC ACID, NICKEL (II) ION
Authors:McDonough, M.A., Gallimore, E., Clifton, I.J., Schofield, C.J.
Deposit date:2016-04-01
Release date:2017-04-12
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:WELO5 SMALL MOLECULE HALOGENASE WITH NI(II) AND 2-OXOGLUTARATE
To Be Published
5J8X
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CRYSTAL STRUCTURE OF E. COLI PBP5 WITH 2C
Descriptor:D-alanyl-D-alanine carboxypeptidase DacA, (R)-3-(4-(AMINOMETHYL)BENZAMIDO)-8-CARBOXY-2,2-DIHYDROXY-3,4-DIHYDRO-2H-BENZO[E][1,2]OXABORININ-2-UIDE
Authors:Brem, J., Cain, R., McDonough, M.A., Clifton, I.J., Fishwick, C.W.G., Schofield, C.J.
Deposit date:2016-04-08
Release date:2016-08-17
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Structural basis of metallo-beta-lactamase, serine-beta-lactamase and penicillin-binding protein inhibition by cyclic boronates.
Nat Commun, 7, 2016
5OP6
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FACTOR INHIBITING HIF (FIH) IN COMPLEX WITH ZINC AND GSK128863
Descriptor:Hypoxia-inducible factor 1-alpha inhibitor, ZINC ION, SULFATE ION, ...
Authors:Leissing, T.M., Schofield, C.J., Clifton, I.J., Thinnes, C.C., Lu, X.
Deposit date:2017-08-09
Release date:2017-10-18
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials.
Chem Sci, 8, 2017
5OP8
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FACTOR INHIBITING HIF (FIH) IN COMPLEX WITH ZINC AND MOLIDUSTAT
Descriptor:Hypoxia-inducible factor 1-alpha inhibitor, ZINC ION, 2-(6-morpholin-4-ylpyrimidin-4-yl)-4-(1,2,3-triazol-1-yl)-1~{H}-pyrazol-3-one, ...
Authors:Leissing, T.M., Schofield, C.J., Clifton, I.J., Lu, X.
Deposit date:2017-08-09
Release date:2017-10-18
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials.
Chem Sci, 8, 2017
5OPC
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FACTOR INHIBITING HIF (FIH) IN COMPLEX WITH ZINC AND VADADUSTAT
Descriptor:Hypoxia-inducible factor 1-alpha inhibitor, SULFATE ION, ZINC ION, ...
Authors:Leissing, T.M., Schofield, C.J., Clifton, I.J., Lu, X., Zhang, D.
Deposit date:2017-08-09
Release date:2017-10-18
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials.
Chem Sci, 8, 2017
5T22
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WELO5 SMALL MOLECULE HALOGENASE WITH NI(II) AND 2-OXOGLUTARATE P 21 CRYSTAL FORM
Descriptor:WelO5, NICKEL (II) ION, 2-OXOGLUTARIC ACID
Authors:Gallimore, E.O., McDonough, M.A., Clifton, I.J.
Deposit date:2016-08-23
Release date:2017-08-23
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:WELO5 SMALL MOLECULE HALOGENASE WITH NI(II) AND 2-OXOGLUTARATE
To Be Published
5TRQ
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WELO5 SMALL MOLECULE HALOGENASE WITH NI(II) AND SUCCINATE
Descriptor:WelO5, NICKEL (II) ION, SUCCINIC ACID, ...
Authors:McDonough, M.A., Gallimore, E., Clifton, I.J.
Deposit date:2016-10-27
Release date:2017-11-29
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:WELO5 SMALL MOLECULE HALOGENASE WITH NI(II) AND SUCCINATE
To be published
2Y34
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S-NITROSYLATED PHD2 (NO EXPOSED) IN COMPLEX WITH FE(II) AND UN9
Descriptor:EGL NINE HOMOLOG 1, FE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE
Authors:Chowdhury, R., McDonough, M.A., Schofield, C.J.
Deposit date:2010-12-18
Release date:2010-12-29
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1).
J. Mol. Biol., 410, 2011
5FQ9
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CRYSTAL STRUCTURE OF THE OXA10 WITH 1C
Descriptor:BETA-LACTAMASE OXA-10, (3R)-3-(cyclohexylcarbonylamino)-2-oxidanyl-3,4-dihydro-1,2-benzoxaborinine-8-carboxylic acid, GLYCEROL, ...
Authors:Brem, J., McDonough, M.A., Cain, R., Clifton, I., Fishwick, C.W.G., Schofield, C.J.
Deposit date:2015-12-08
Release date:2016-08-17
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis of metallo-beta-lactamase, serine-beta-lactamase and penicillin-binding protein inhibition by cyclic boronates.
Nat Commun, 7, 2016