1QJF

ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (Monocyclic Sulfoxide - Fe COMPLEX)

Summary for 1QJF

• Entry DOI: 10.2210/pdb1qjf/pdb
• Related: 1BK0 1QJE
• Descriptor: ISOPENICILLIN N SYNTHASE, SULFATE ION, 1-[(1S)-CARBOXY-2-(METHYLSULFINYL)ETHYL]-(3R)-[(5S)-5-AMINO-5-CARBOXYPENTANAMIDO]-(4R)-SULFANYLAZETIDIN-2-ONE, ... (5 entities in total)
• Functional Keywords: b-lactam antibiotic, monocyclic intermediate, oxygenase, penicillin biosynthesis, sulfoxide
• Biological source: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
• Total number of polymer chains: 1
• Total formula weight: 38111.20

Authors

Rutledge, P.J.,Clifton, I.J.,Burzlaff, N.I.,Roach, P.L.,Adlington, R.M.,Baldwin, J.E. (deposition date: 1999-06-23, release date: 2000-06-29, Last modification date: 2024-05-08)

• Primary citation: Burzlaff, N.I.,Rutledge, P.J.,Clifton, I.J.,Hensgens, C.M.H.,Pickford, M.,Adlington, R.M.,Roach, P.L.,Baldwin, J.E.; The Reaction Cycle of Isopenicillin N Synthase Observed by X-Ray Diffraction; Nature, 401:721-, 1999; PubMed: 10537113; DOI: 10.1038/44400

Experimental method

X-RAY DIFFRACTION (1.4 Å)