2JB4

Isopenicillin N synthase with a 2-thiabicycloheptan-6-one product analogue

Summary for 2JB4

Entry DOI	10.2210/pdb2jb4/pdb
Related	1BK0 1BLZ 1HB1 1HB2 1HB3 1HB4 1IPS 1OBN 1OC1 1ODM 1ODN 1QIQ 1QJE 1QJF 1UZW 1W03 1W04 1W05 1W06 1W3V 1W3X 2BJS 2BU9 2IVI 2IVJ
Descriptor	ISOPENICILLIN N SYNTHETASE, (1S,4S,5S,7R)-7-{[(5S)-5-AMINO-5-CARBOXYPENTANOYL]AMINO}-3,3-DIMETHYL-6-OXO-2-THIABICYCLO[3.2.0]HEPTANE-4-CARBOXYLIC ACID, FE (III) ION, ... (6 entities in total)
Functional Keywords	antibiotic biosynthesis, penicillin biosynthesis, iron, oxygenase, vitamin c, metal-binding, oxidoreductase, b-lactam antibiotic
Biological source	EMERICELLA NIDULANS
Total number of polymer chains	1
Total formula weight	38262.31
Authors	Stewart, A.C.,Clifton, I.J.,Adlington, R.M.,Baldwin, J.E.,Rutledge, P.J. (deposition date: 2006-12-01, release date: 2007-10-16, Last modification date: 2023-12-13)
Primary citation	Stewart, A.C.,Clifton, I.J.,Adlington, R.M.,Baldwin, J.E.,Rutledge, P.J. A Cyclobutanone Analogue Mimics Penicillin in Binding to Isopenicillin N Synthase. Chembiochem, 8:2003-, 2007 Cited by PubMed: 17907118 DOI: 10.1002/CBIC.200700176 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation