2FFL
 
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2QVW
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9BKQ
 | | Structure of penguinpox cGAMP PDE in apo and post reaction states | | Descriptor: | 9-{3-O-[(S)-thiophosphono]-alpha-L-lyxofuranosyl}-9H-purin-6-amine, GUANINE, Penguinpox cGAMP PDE | | Authors: | Hobbs, S.J, Nomburg, J, Doudna, J.A, Kranzusch, P.J. | | Deposit date: | 2024-04-29 | | Release date: | 2024-09-04 | | Last modified: | 2024-09-11 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Animal and bacterial viruses share conserved mechanisms of immune evasion.
Cell, 2024
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9CIW
 | | Penguinpox cGAMP PDE H72A mutant in complex with 2'3'-cGAMP | | Descriptor: | Penguinpox cGAMP PDE, [(2~{R},3~{R},4~{R},5~{S})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl [(2~{R},3~{R},4~{S},5~{R})-2-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-5-(hydroxymethyl)-4-oxidanyl-oxolan-3-yl] hydrogen phosphate | | Authors: | Hobbs, S.J, Nomburg, J, Doudna, J.A, Kranzusch, P.J. | | Deposit date: | 2024-07-05 | | Release date: | 2024-09-04 | | Last modified: | 2024-09-11 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Animal and bacterial viruses share conserved mechanisms of immune evasion.
Cell, 2024
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1HQ1
 | | STRUCTURAL AND ENERGETIC ANALYSIS OF RNA RECOGNITION BY A UNIVERSALLY CONSERVED PROTEIN FROM THE SIGNAL RECOGNITION PARTICLE | | Descriptor: | 4.5S RNA DOMAIN IV, MAGNESIUM ION, POTASSIUM ION, ... | | Authors: | Batey, R.T, Sagar, M.B, Doudna, J.A. | | Deposit date: | 2000-12-13 | | Release date: | 2001-01-03 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.52 Å) | | Cite: | Structural and energetic analysis of RNA recognition by a universally conserved protein from the signal recognition particle.
J.Mol.Biol., 307, 2001
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2XLI
 | | Crystal structure of the Csy4-crRNA complex, monoclinic form | | Descriptor: | 5'-R(*CP*UP*GP*CP*CP*GP*UP*AP*UP*AP*GP*GP*CP*A*DG*C)-3', CSY4 ENDORIBONUCLEASE | | Authors: | Haurwitz, R.E, Jinek, M, Wiedenheft, B, Zhou, K, Doudna, J.A. | | Deposit date: | 2010-07-20 | | Release date: | 2010-09-22 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.33 Å) | | Cite: | Sequence- and Structure-Specific RNA Processing by a Crispr Endonuclease.
Science, 329, 2010
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6VPC
 | | Structure of the SpCas9 DNA adenine base editor - ABE8e | | Descriptor: | CRISPR-associated endonuclease Cas9, Cas9 (SpCas9) single-guide RNA (sgRNA), DNA non-target strand (NTS), ... | | Authors: | Knott, G.J, Lapinaite, A, Doudna, J.A. | | Deposit date: | 2020-02-03 | | Release date: | 2020-07-29 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | DNA capture by a CRISPR-Cas9-guided adenine base editor.
Science, 369, 2020
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7S37
 | | Cas9:sgRNA (S. pyogenes) in the open-protein conformation | | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, Single-guide RNA | | Authors: | Cofsky, J.C, Soczek, K.M, Knott, G.J, Nogales, E, Doudna, J.A. | | Deposit date: | 2021-09-04 | | Release date: | 2022-04-20 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | CRISPR-Cas9 bends and twists DNA to read its sequence.
Nat.Struct.Mol.Biol., 29, 2022
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7S3H
 | | Cas9:sgRNA:DNA (S. pyogenes) with 0 RNA:DNA base pairs, open-protein/linear-DNA conformation | | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, Non-target DNA strand, Single-guide RNA, ... | | Authors: | Cofsky, J.C, Soczek, K.M, Knott, G.J, Nogales, E, Doudna, J.A. | | Deposit date: | 2021-09-06 | | Release date: | 2022-04-20 | | Last modified: | 2022-05-04 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | CRISPR-Cas9 bends and twists DNA to read its sequence.
Nat.Struct.Mol.Biol., 29, 2022
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7S36
 | | Cas9:sgRNA:DNA (S. pyogenes) with 0 RNA:DNA base pairs, closed-protein/bent-DNA conformation | | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, Non-target DNA strand, Single-guide RNA, ... | | Authors: | Cofsky, J.C, Soczek, K.M, Knott, G.J, Nogales, E, Doudna, J.A. | | Deposit date: | 2021-09-04 | | Release date: | 2022-04-20 | | Last modified: | 2022-05-04 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | CRISPR-Cas9 bends and twists DNA to read its sequence.
Nat.Struct.Mol.Biol., 29, 2022
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7S38
 | | Cas9:sgRNA:DNA (S. pyogenes) forming a 3-base-pair R-loop | | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, Non-target DNA strand, Single-guide RNA, ... | | Authors: | Cofsky, J.C, Soczek, K.M, Knott, G.J, Nogales, E, Doudna, J.A. | | Deposit date: | 2021-09-04 | | Release date: | 2022-04-20 | | Last modified: | 2022-05-04 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | CRISPR-Cas9 bends and twists DNA to read its sequence.
Nat.Struct.Mol.Biol., 29, 2022
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4WYQ
 | | Crystal structure of the Dicer-TRBP interface | | Descriptor: | Endoribonuclease Dicer, Poly(UNK), RISC-loading complex subunit TARBP2 | | Authors: | Wilson, R.C, Doudna, J.A. | | Deposit date: | 2014-11-18 | | Release date: | 2014-12-17 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Dicer-TRBP Complex Formation Ensures Accurate Mammalian MicroRNA Biogenesis.
Mol.Cell, 57, 2015
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6MCC
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6MCB
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7THB
 | | Crystal structure of an RNA-5'/DNA-3' strand exchange junction | | Descriptor: | DNA (5'-D(*GP*AP*TP*GP*CP*TP*C)-3'), DNA (5'-D(*GP*TP*AP*AP*GP*CP*AP*GP*CP*AP*TP*C)-3'), RNA (5'-R(*AP*GP*CP*UP*UP*AP*C)-3') | | Authors: | Cofsky, J.C, Knott, G.J, Gee, C.L, Doudna, J.A. | | Deposit date: | 2022-01-10 | | Release date: | 2022-04-27 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.64 Å) | | Cite: | Crystal structure of an RNA/DNA strand exchange junction.
Plos One, 17, 2022
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5I4A
 | | X-ray crystal structure of Marinitoga piezophila Argonaute in complex with 5' OH guide RNA | | Descriptor: | Argonaute protein, RNA (5'-R(*UP*AP*UP*AP*CP*AP*AP*CP*CP*UP*AP*CP*UP*U)-3') | | Authors: | Doxzen, K.W, Kaya, E, Knoll, K.R, Wilson, R.C, Strutt, S.C, Kranzusch, P.J, Doudna, J.A. | | Deposit date: | 2016-02-11 | | Release date: | 2016-03-30 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.949 Å) | | Cite: | A bacterial Argonaute with noncanonical guide RNA specificity.
Proc.Natl.Acad.Sci.USA, 113, 2016
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1GID
 | | CRYSTAL STRUCTURE OF A GROUP I RIBOZYME DOMAIN: PRINCIPLES OF RNA PACKING | | Descriptor: | COBALT HEXAMMINE(III), MAGNESIUM ION, P4-P6 RNA RIBOZYME DOMAIN | | Authors: | Cate, J.H, Gooding, A.R, Podell, E, Zhou, K, Golden, B.L, Kundrot, C.E, Cech, T.R, Doudna, J.A. | | Deposit date: | 1996-08-22 | | Release date: | 1996-12-31 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of a group I ribozyme domain: principles of RNA packing.
Science, 273, 1996
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3T4B
 | | Crystal Structure of the HCV IRES pseudoknot domain | | Descriptor: | HCV IRES pseudoknot domain plus crystallization module, NICKEL (II) ION | | Authors: | Berry, K.E, Waghray, S, Mortimer, S.A, Bai, Y, Doudna, J.A. | | Deposit date: | 2011-07-25 | | Release date: | 2011-10-12 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.55 Å) | | Cite: | Crystal structure of the HCV IRES central domain reveals strategy for start-codon positioning.
Structure, 19, 2011
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3FRX
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8VXY
 | | Structure of HamA(E138A,K140A)B-plasmid DNA complex from the Escherichia coli Hachiman defense system | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, HamA, HamB, ... | | Authors: | Tuck, O.T, Hu, J.J, Doudna, J.A. | | Deposit date: | 2024-02-06 | | Release date: | 2024-03-13 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.19 Å) | | Cite: | Hachiman is a genome integrity sensor.
Biorxiv, 2024
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8VXA
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8VXC
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8VX9
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8UZB
 | | Cryo-EM structure of iGeoCas9 in complex with sgRNA and target DNA | | Descriptor: | CRISPR-associated endonuclease Cas9, Non-target strand DNA, RNA (107-MER), ... | | Authors: | Eggers, A.R, Soczek, K.M, Tuck, O.T, Doudna, J.A. | | Deposit date: | 2023-11-14 | | Release date: | 2024-05-29 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (2.63 Å) | | Cite: | Rapid DNA unwinding accelerates genome editing by engineered CRISPR-Cas9.
Cell, 187, 2024
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8UZA
 | | Cryo-EM structure of GeoCas9 in complex with sgRNA and target DNA | | Descriptor: | CRISPR-associated endonuclease Cas9, Non-target strand DNA, Target strand DNA, ... | | Authors: | Eggers, A.R, Soczek, K.M, Tuck, O.T, Doudna, J.A. | | Deposit date: | 2023-11-14 | | Release date: | 2024-05-29 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.17 Å) | | Cite: | Rapid DNA unwinding accelerates genome editing by engineered CRISPR-Cas9.
Cell, 187, 2024
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