Author results

2JQN
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SOLUTION NMR STRUCTURE OF CC0527 FROM CAULOBACTER CRESCENTUS. NORTHEAST STRUCTURAL GENOMICS TARGET CCR55
Descriptor:Hypothetical protein
Authors:Aramini, J.M., Rossi, P., Moseley, H.N.B., Wang, D., Nwosu, C., Cunningham, K., Ma, L., Xiao, R., Liu, J., Baran, M.C., Swapna, G.V.T., Acton, T.B., Rost, B., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2007-06-05
Release date:2007-07-03
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution NMR structure of CC0527 from Caulobacter crescentus
To be Published
2KT1
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SOLUTION NMR STRUCTURE OF THE SH3 DOMAIN FROM THE P85BETA SUBUNIT OF PHOSPHATIDYLINOSITOL 3-KINASE FROM H.SAPIENS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET HR5531E
Descriptor:Phosphatidylinositol 3-kinase regulatory subunit beta
Authors:Aramini, J.M., Ma, L., Schauder, C., Everett, J.K., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2010-01-15
Release date:2010-01-26
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution NMR Structure of the SH3 Domain from the p85beta subunit of Phosphatidylinositol 3-kinase from H.sapiens, Northeast Structural Genomics Consortium Target HR5531E
To be Published
4PXZ
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CRYSTAL STRUCTURE OF P2Y12 RECEPTOR IN COMPLEX WITH 2MESADP
Descriptor:P2Y purinoceptor 12, Soluble cytochrome b562, 2-(methylsulfanyl)adenosine 5'-(trihydrogen diphosphate), ...
Authors:Zhang, J., Zhang, K., Gao, Z.G., Paoletta, S., Zhang, D., Han, G.W., Li, T., Ma, L., Zhang, W., Muller, C.E., Yang, H., Jiang, H., Cherezov, V., Katritch, V., Jacobson, K.A., Stevens, R.C., Wu, B., Zhao, Q., GPCR Network (GPCR)
Deposit date:2014-03-25
Release date:2014-04-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Agonist-bound structure of the human P2Y12 receptor
Nature, 509, 2014
4PY0
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CRYSTAL STRUCTURE OF P2Y12 RECEPTOR IN COMPLEX WITH 2MESATP
Descriptor:P2Y purinoceptor 12, Soluble cytochrome b562, 2-(methylsulfanyl)adenosine 5'-(tetrahydrogen triphosphate), ...
Authors:Zhang, J., Zhang, K., Gao, Z.G., Paoletta, S., Zhang, D., Han, G.W., Li, T., Ma, L., Zhang, W., Muller, C.E., Yang, H., Jiang, H., Cherezov, V., Katritch, V., Jacobson, K.A., Stevens, R.C., Wu, B., Zhao, Q., GPCR Network (GPCR)
Deposit date:2014-03-25
Release date:2014-04-30
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Agonist-bound structure of the human P2Y12 receptor
Nature, 509, 2014
5JP2
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FCHO1 MU HOMOLOGY DOMAIN (DANIO RERIO) WITH BOUND EPS15 PEPTIDE
Descriptor:Epidermal growth factor receptor substrate 15, F-BAR domain only protein 1, ZINC ION
Authors:McCoy, A.J., Wrobel, A., Owen, D.J.
Deposit date:2016-05-03
Release date:2016-06-08
Last modified:2016-06-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Transient Fcho1/2Eps15/RAP-2 Nanoclusters Prime the AP-2 Clathrin Adaptor for Cargo Binding.
Dev.Cell, 37, 2016
6JCN
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YEAST DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1
Descriptor:Dehydrodolichyl diphosphate synthase complex subunit NUS1, SULFATE ION
Authors:Ko, T.-P., Ma, J., Liu, W., Chen, C.-C., Guo, R.-T.
Deposit date:2019-01-29
Release date:2019-06-19
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (1.998 Å)
Cite:Structural insights to heterodimeric cis-prenyltransferases through yeast dehydrodolichyl diphosphate synthase subunit Nus1.
Biochem.Biophys.Res.Commun., 515, 2019
5DIL
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CRYSTAL STRUCTURE OF THE EFFECTOR DOMAIN OF THE NS1 PROTEIN FROM INFLUENZA VIRUS B
Descriptor:Non-structural protein 1, IODIDE ION
Authors:Guan, R., Hamilton, K., Ma, L., Montelione, G.T.
Deposit date:2015-09-01
Release date:2016-08-10
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:A Second RNA-Binding Site in the NS1 Protein of Influenza B Virus.
Structure, 24, 2016
1R57
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NMR SOLUTION STRUCTURE OF A GCN5-LIKE PUTATIVE N-ACETYLTRANSFERASE FROM STAPHYLOCOCCUS AUREUS. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET ZR31
Descriptor:conserved hypothetical protein
Authors:Cort, J.R., Acton, T.B., Ma, L., Xiao, R.B., Montelione, G.T., Kennedy, M.A., Northeast Structural Genomics Consortium (NESG)
Deposit date:2003-10-09
Release date:2004-03-09
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of an acetyl-CoA binding protein from Staphylococcus aureus representing a novel subfamily of GCN5-related N-acetyltransferase-like proteins.
J.STRUCT.FUNCT.GENOM., 9, 2008
1ZTS
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SOLUTION STRUCTURE OF BACILLUS SUBTILIS PROTEIN YQBG: NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET SR215
Descriptor:Hypothetical protein yqbG
Authors:Liu, G., Shen, Y., Xiao, R., Acton, T., Ma, L., Joachimiak, A., Montelione, G.T., Szyperski, T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2005-05-27
Release date:2005-07-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR structure of protein yqbG from Bacillus subtilis reveals a novel alpha-helical protein fold.
Proteins, 62, 2006
2H5M
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NMR SOLUTION STRUCTURE OF A GCN5-LIKE PUTATIVE N-ACETYLTRANSFERASE FROM STAPHYLOCOCCUS AUREUS COMPLEXED WITH ACETYL-COA. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET ZR31
Descriptor:Acetyltransferase, GNAT family, ACETYL COENZYME *A
Authors:Cort, J.R., Ramelot, T.A., Acton, T.B., Ma, L., Xiao, R.B., Montelione, G.T., Kennedy, M.A., Northeast Structural Genomics Consortium (NESG)
Deposit date:2006-05-26
Release date:2006-11-28
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of an acetyl-CoA binding protein from Staphylococcus aureus representing a novel subfamily of GCN5-related N-acetyltransferase-like proteins
J.Struct.Funct.Genom., 9, 2008
2LP6
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REFINED SOLUTION NMR STRUCTURE OF THE 50S RIBOSOMAL PROTEIN L35AE FROM PYROCOCCUS FURIOSUS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET (NESG) PFR48
Descriptor:50S ribosomal protein L35Ae
Authors:Snyder, D.A., Aramini, J.M., Yu, B., Huang, Y.J., Xiao, R., Cort, J.R., Shastry, R., Ma, L., Liu, J., Rost, B., Acton, T.B., Kennedy, M.A., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2012-02-02
Release date:2012-02-15
Last modified:2012-06-20
Method:SOLUTION NMR
Cite:Solution NMR structure of the ribosomal protein RP-L35Ae from Pyrococcus furiosus.
Proteins, 80, 2012
3UIV
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HUMAN SERUM ALBUMIN-MYRISTATE-AMANTADINE HYDROCHLORIDE COMPLEX
Descriptor:Serum albumin, MYRISTIC ACID, (3S,5S,7S)-tricyclo[3.3.1.1~3,7~]decan-1-amine
Authors:Yang, F., Ma, Z., Ma, L., Yang, G.
Deposit date:2011-11-06
Release date:2012-11-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis of the drug-binding specificity of human serum albumin
TO BE PUBLISHED
6JCJ
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STRUCTURE OF CROLIBULIN IN COMPLEX WITH TUBULIN
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Zhang, Z., Yang, J.
Deposit date:2019-01-29
Release date:2019-03-13
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular mechanism of crolibulin in complex with tubulin provides a rationale for drug design.
Biochem. Biophys. Res. Commun., 511, 2019
2JRT
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NMR SOLUTION STRUCTURE OF THE PROTEIN CODED BY GENE RHOS4_12090 OF RHODOBACTER SPHAEROIDES. NORTHEAST STRUCTURAL GENOMICS TARGET RHR5
Descriptor:Uncharacterized protein
Authors:Wang, L., Chen, C., Nwosu, C., Cunningham, K., Owens, L., Ma, L., Xiao, R., Liu, J., Baran, M.C., Swapna, G., Acton, T.B., Rost, B., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2007-06-28
Release date:2007-08-21
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR solution structure of the protein coded by gene RHOS4_12090 of Rhodobacter sphaeroides.
To be Published
4HZL
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NEUTRALIZING ANTIBODY MAB#8 IN COMPLEX WITH THE EPITOPE II OF HCV E2 ENVELOPE PROTEIN
Descriptor:Fab heavy chain, Fab light chain, E2 envelop protein
Authors:Deng, L., Zhang, P.
Deposit date:2012-11-15
Release date:2013-05-01
Last modified:2013-05-15
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural evidence for a bifurcated mode of action in the antibody-mediated neutralization of hepatitis C virus.
Proc.Natl.Acad.Sci.USA, 110, 2013
4Q0X
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CRYSTAL STRUCTURE OF NON-NEUTRALIZING ANTIBODY IN COMPLEX WITH EPITOPE II OF HCV E2
Descriptor:mAb 12 heavy chain, mAb 12 light chain, Envelope glycoprotein E2
Authors:Deng, L., Zhang, P.
Deposit date:2014-04-02
Release date:2014-07-09
Last modified:2014-08-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Discrete conformations of epitope II on the hepatitis C virus E2 protein for antibody-mediated neutralization and nonneutralization.
Proc.Natl.Acad.Sci.USA, 111, 2014
3RK0
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X-RAY CRYSTAL STRUCTURE OF THE PUTATIVE N-TYPE ATP PYROPHOSPHATASE (PF0828) IN COMPLEX WITH AMP FROM PYROCOCCUS FURIOSUS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET PFR23
Descriptor:N-type ATP pyrophosphatase superfamily, ADENOSINE MONOPHOSPHATE
Authors:Forouhar, F., Saadat, N., Hussain, M., Seetharaman, J., Janjua, J., Xiao, R., Cunningham, K., Ma, L., Shastry, R., Everett, J.K., Nair, R., Acton, T.B., Rost, B., Montelione, G.T., Hunt, J.F., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2011-04-16
Release date:2011-05-11
Last modified:2012-01-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A large conformational change in the putative ATP pyrophosphatase PF0828 induced by ATP binding.
Acta Crystallogr.,Sect.F, 67, 2011
3RK1
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'X-RAY CRYSTAL STRUCTURE OF THE PUTATIVE N-TYPE ATP PYROPHOSPHATASE (PF0828) IN COMPLEX WITH ATP FROM PYROCOCCUS FURIOSUS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET PFR23
Descriptor:N-type ATP pyrophosphatase superfamily, ADENOSINE-5'-TRIPHOSPHATE, PHOSPHATE ION
Authors:Forouhar, F., Seetharaman, J., Janjua, J., Xiao, R., Cunningham, K., Ma, L., Shastry, R., Everett, J.K., Nair, R., Acton, T.B., Rost, B., Montelione, G.T., Hunt, J.F., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2011-04-16
Release date:2011-05-11
Last modified:2012-01-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A large conformational change in the putative ATP pyrophosphatase PF0828 induced by ATP binding.
Acta Crystallogr.,Sect.F, 67, 2011
4IVS
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CRYSTAL STRUCTURE OF BACE1 WITH ITS INHIBITOR
Descriptor:Beta-secretase 1, N-{N-[4-(acetylamino)-3,5-dichlorobenzyl]carbamimidoyl}-2-(6-cyano-1H-indol-1-yl)acetamide
Authors:Chen, T.T., Li, L., Chen, W.Y., Xu, Y.C.
Deposit date:2013-01-23
Release date:2013-11-13
Method:X-RAY DIFFRACTION (2.636 Å)
Cite:Virtual screening and structure-based discovery of indole acylguanidines as potent beta-secretase (BACE1) inhibitors
Molecules, 18, 2013
4IVT
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CRYSTAL STRUCTURE OF BACE1 WITH ITS INHIBITOR
Descriptor:Beta-secretase 1, N-{N-[4-(acetylamino)-3,5-dichlorobenzyl]carbamimidoyl}-2-(1H-indol-1-yl)acetamide, SULFATE ION
Authors:Chen, T.T., Li, L., Chen, W.Y., Xu, Y.C.
Deposit date:2013-01-23
Release date:2013-11-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Virtual screening and structure-based discovery of indole acylguanidines as potent beta-secretase (BACE1) inhibitors
Molecules, 18, 2013
5JHG
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE HUMAN RHOA AND THE DH/PH DOMAIN OF HUMAN ARHGEF11
Descriptor:Rho guanine nucleotide exchange factor 11, Transforming protein RhoA, GLYCEROL
Authors:Wang, R., Chen, Q., Zhang, H., Yan, Z., Li, J., Miao, L., Wang, F.
Deposit date:2016-04-21
Release date:2017-04-26
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA bound with its inhibitor and ARHGEF11
To Be Published
1YWL
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SOLUTION NMR STRUCTURE OF THE PROTEIN EF2693 FROM E. FAECALIS: NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET EFR36
Descriptor:Hypothetical UPF0213 protein EF2693
Authors:Northeast Structural Genomics Consortium (NESG)
Deposit date:2005-02-18
Release date:2005-03-29
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution NMR structure of the protein EF2693 from E. faecalis: Northeast Structural Genomics Consortium target EFR36
To be Published
2JN7
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NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET ER411
Descriptor:protein yfjZ
Authors:Tian, F., Zhao, L., Jiang, M., Cunningham, K., Ma, L., Xiao, R., Liu, J., Baran, M., Swapna, G.V.T., Acton, T.B., Rost, B., Montelione, G.T., Prestegard, J.H., Northeast Structural Genomics Consortium (NESG)
Deposit date:2006-12-28
Release date:2007-01-09
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR solution structure of E.Coli hypothetical protein YFJZ
To be Published
4QXM
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CRYSTAL STRUCTURE OF THE INHA:GSK_SB713 COMPLEX
Descriptor:Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, N-(2-chloro-4-fluorobenzyl)-4-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]benzamide
Authors:Gulten, G., Sacchettini, J.C.
Deposit date:2014-07-21
Release date:2015-07-22
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (2.196 Å)
Cite:N-Benzyl-4-((heteroaryl)methyl)benzamides: A New Class of Direct NADH-Dependent 2-trans Enoyl-Acyl Carrier Protein Reductase (InhA) Inhibitors with Antitubercular Activity.
Chemmedchem, 11, 2016
5INW
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STRUCTURE OF REACTION LOOP CLEAVED LAMPREY ANGIOTENSINOGEN
Descriptor:Putative angiotensinogen, C-terminal peptide of Putative angiotensinogen, SULFATE ION
Authors:Wei, H., Zhou, A.
Deposit date:2016-03-08
Release date:2016-10-05
Last modified:2016-12-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Heparin Binds Lamprey Angiotensinogen and Promotes Thrombin Inhibition through a Template Mechanism
J.Biol.Chem., 291, 2016