Author results

3LDA
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YEAST RAD51 H352Y FILAMENT INTERFACE MUTANT
Descriptor:DNA repair protein RAD51, CHLORIDE ION
Authors:Villanueva, N.L., Chen, J., Morrical, S.W., Rould, M.A.
Deposit date:2010-01-12
Release date:2010-04-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Insights into the mechanism of Rad51 recombinase from the structure and properties of a filament interface mutant.
Nucleic Acids Res., 38, 2010
4XAX
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS CARD IN COMPLEX WITH THE THERMUS AQUATICUS RNA POLYMERASE BETA1 DOMAIN
Descriptor:DNA-directed RNA polymerase subunit beta domain 1, CarD, 1,2-ETHANEDIOL
Authors:Chen, J., Bae, B., Campbell, E.A., Darst, S.A.
Deposit date:2014-12-15
Release date:2015-09-16
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.404 Å)
Cite:CarD uses a minor groove wedge mechanism to stabilize the RNA polymerase open promoter complex.
Elife, 4, 2015
4MSU
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HUMAN GKRP BOUND TO AMG-6861 AND SORBITOL-6-PHOSPHATE
Descriptor:Glucokinase regulatory protein, 1,1,1,3,3,3-hexafluoro-2-{4-[4-(thiophen-2-ylsulfonyl)piperazin-1-yl]phenyl}propan-2-ol, D-SORBITOL-6-PHOSPHATE, ...
Authors:Ashton, K.S., Andrews, K.L., Bryan, M.C., Chen, J., Chen, K., Chen, M., Chmait, S., Croghan, M., Cupples, R., Fotsch, C., Helmering, J., Jordan, S.R., Kurzeja, R.J., Michelsen, K., Pennington, L.D., Poon, S.F., Sivits, G., Van, G., Vonderfecht, S.L., Wahl, R.C., Zhang, J., Lloyd, D.J., Hale, C., St Jean, D.J.
Deposit date:2013-09-18
Release date:2014-03-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept.
J.Med.Chem., 57, 2014
3PCU
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CRYSTAL STRUCTURE OF HUMAN RETINOIC X RECEPTOR ALPHA LIGAND-BINDING DOMAIN COMPLEXED WITH LX0278 AND SRC1 PEPTIDE
Descriptor:Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, 2-[(2S)-6-(2-methylbut-3-en-2-yl)-7-oxo-2,3-dihydro-7H-furo[3,2-g]chromen-2-yl]propan-2-yl acetate
Authors:Zhang, H., Zhang, Y., Shen, H., Chen, J., Li, C., Chen, L., Hu, L., Jiang, H., Shen, X.
Deposit date:2010-10-22
Release date:2011-11-16
Last modified:2012-04-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:(+)-Rutamarin as a Dual Inducer of Both GLUT4 Translocation and Expression Efficiently Ameliorates Glucose Homeostasis in Insulin-Resistant Mice.
Plos One, 7, 2012
3N3Y
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CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE X (THYX) FROM HELICOBACTER PYLORI WITH FAD AND DUMP AT 2.31A RESOLUTION
Descriptor:Thymidylate synthase thyX, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Wang, K., Wang, Q., Chen, J., Chen, L., Jiang, H., Shen, X.
Deposit date:2010-05-21
Release date:2011-05-25
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.307 Å)
Cite:Structure, Enzymatic Characterization and Inhibitor Discovery of Thymidylate Synthase X (ThyX) from Helicobacter pylori Strain SS1
To be Published
3P30
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CRYSTAL STRUCTURE OF THE CLUSTER II FAB 1281 IN COMPLEX WITH HIV-1 GP41 ECTODOMAIN
Descriptor:HIV-1 gp41, 1281 Fab light chain, 1281 Fab heavy chain
Authors:Frey, G., Chen, J., Rits-Volloch, S., Freeman, M.M., Zolla-Pazner, S., Chen, B.
Deposit date:2010-10-04
Release date:2010-11-17
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Distinct conformational states of HIV-1 gp41 are recognized by neutralizing and non-neutralizing antibodies.
Nat.Struct.Mol.Biol., 17, 2010
3R29
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CRYSTAL STRUCTURE OF RXRALPHA LIGAND-BINDING DOMAIN COMPLEXED WITH COREPRESSOR SMRT2
Descriptor:Retinoic acid receptor RXR-alpha, Nuclear receptor corepressor 2
Authors:Zhang, H., Chen, L., Chen, J., Jiang, H., Shen, X.
Deposit date:2011-03-14
Release date:2011-05-25
Last modified:2011-07-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for retinoic x receptor repression on the tetramer.
J.Biol.Chem., 286, 2011
3R2A
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CRYSTAL STRUCTURE OF RXRALPHA LIGAND-BINDING DOMAIN COMPLEXED WITH COREPRESSOR SMRT2 AND ANTAGONIST RHEIN
Descriptor:Retinoic acid receptor RXR-alpha, Nuclear receptor corepressor 2, 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid
Authors:Zhang, H., Chen, L., Chen, J., Jiang, H., Shen, X.
Deposit date:2011-03-14
Release date:2011-05-25
Last modified:2011-07-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for retinoic x receptor repression on the tetramer.
J.Biol.Chem., 286, 2011
3R5M
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CRYSTAL STRUCTURE OF RXRALPHALBD COMPLEXED WITH THE AGONIST MAGNOLOL
Descriptor:Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, 5,5'-di(prop-2-en-1-yl)biphenyl-2,2'-diol
Authors:Zhang, H., Chen, L., Chen, J., Hu, L., Jiang, H., Shen, X.
Deposit date:2011-03-18
Release date:2012-02-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular determinants of magnolol targeting both RXR(alpha) and PPAR(gamma).
Plos One, 6, 2011
3R5N
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CRYSTAL STRUCTURE OF PPARGAMMALBD COMPLEXED WITH THE AGONIST MAGNOLOL
Descriptor:Peroxisome proliferator-activated receptor gamma, 5,5'-di(prop-2-en-1-yl)biphenyl-2,2'-diol
Authors:Zhang, H., Chen, L., Chen, J., Hu, L., Jiang, H., Shen, X.
Deposit date:2011-03-18
Release date:2012-02-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular determinants of magnolol targeting both RXR(alpha) and PPAR(gamma).
Plos One, 6, 2011
4JBW
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CRYSTAL STRUCTURE OF E. COLI MALTOSE TRANSPORTER MALFGK2 IN COMPLEX WITH ITS REGULATORY PROTEIN EIIAGLC
Descriptor:Maltose transport system permease protein MalF, Maltose transport system permease protein MalG, Maltose/maltodextrin import ATP-binding protein MalK, ...
Authors:Chen, S., Oldham, M.L., Davidson, A.L., Chen, J.
Deposit date:2013-02-20
Release date:2013-06-12
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (3.913 Å)
Cite:Carbon catabolite repression of the maltose transporter revealed by X-ray crystallography.
Nature, 499, 2013
4KHZ
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CRYSTAL STRUCTURE OF THE MALTOSE-BINDING PROTEIN/MALTOSE TRANSPORTER COMPLEX IN AN PRE-TRANSLOCATION CONFORMATION BOUND TO MALTOHEPTAOSE
Descriptor:Maltose-binding periplasmic protein, Maltose transport system permease protein MalF, Binding-protein-dependent transport systems inner membrane component, ...
Authors:Oldham, M.L., Chen, S., Chen, J.
Deposit date:2013-05-01
Release date:2013-10-23
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for substrate specificity in the Escherichia coli maltose transport system.
Proc.Natl.Acad.Sci.USA, 110, 2013
4KI0
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CRYSTAL STRUCTURE OF THE MALTOSE-BINDING PROTEIN/MALTOSE TRANSPORTER COMPLEX IN AN OUTWARD-FACING CONFORMATION BOUND TO MALTOHEXAOSE
Descriptor:ABC transporter related protein, Maltose-binding periplasmic protein, Maltose transport system permease protein MalF, ...
Authors:Oldham, M.L., Chen, S., Chen, J.
Deposit date:2013-05-01
Release date:2013-10-23
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Structural basis for substrate specificity in the Escherichia coli maltose transport system.
Proc.Natl.Acad.Sci.USA, 110, 2013
4R29
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CRYSTAL STRUCTURE OF BACTERIAL CYSTEINE METHYLTRANSFERASE EFFECTOR NLEE
Descriptor:Uncharacterized protein, S-ADENOSYLMETHIONINE, GLYCEROL, ...
Authors:Yao, Q., Chen, J., Hu, L., Zhang, L., Shao, F.
Deposit date:2014-08-11
Release date:2014-12-03
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Structure and Specificity of the Bacterial Cysteine Methyltransferase Effector NleE Suggests a Novel Substrate in Human DNA Repair Pathway.
Plos Pathog., 10, 2014
2QYU
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CRYSTAL STRUCTURE OF SALMONELLA EFFECTOR PROTEIN SOPA
Descriptor:Secreted effector protein, PHOSPHATE ION, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Diao, J., Chen, J.
Deposit date:2007-08-15
Release date:2007-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of SopA, a Salmonella effector protein mimicking a eukaryotic ubiquitin ligase.
Nat.Struct.Mol.Biol., 15, 2008
2QZA
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CRYSTAL STRUCTURE OF SALMONELLA EFFECTOR PROTEIN SOPA
Descriptor:Secreted effector protein
Authors:Diao, J., Chen, J.
Deposit date:2007-08-16
Release date:2007-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of SopA, a Salmonella effector protein mimicking a eukaryotic ubiquitin ligase.
Nat.Struct.Mol.Biol., 15, 2008
1BBU
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LYSYL-TRNA SYNTHETASE (LYSS) COMPLEXED WITH LYSINE
Descriptor:PROTEIN (LYSYL-TRNA SYNTHETASE), LYSINE
Authors:Onesti, S., Desogus, G., Brevet, A., Chen, J., Plateau, P., Blanquet, S., Brick, P.
Deposit date:1998-04-24
Release date:2000-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural studies of lysyl-tRNA synthetase: conformational changes induced by substrate binding.
Biochemistry, 39, 2000
1BBW
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LYSYL-TRNA SYNTHETASE (LYSS)
Descriptor:PROTEIN (LYSYL-TRNA SYNTHETASE)
Authors:Onesti, S., Desogus, G., Brevet, A., Chen, J., Plateau, P., Blanquet, S., Brick, P.
Deposit date:1998-04-24
Release date:2000-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural studies of lysyl-tRNA synthetase: conformational changes induced by substrate binding.
Biochemistry, 39, 2000
1LNQ
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CRYSTAL STRUCTURE OF MTHK AT 3.3 A
Descriptor:POTASSIUM CHANNEL RELATED PROTEIN, CALCIUM ION
Authors:Jiang, Y., Lee, A., Chen, J., Cadene, M., Chait, B.T., Mackinnon, R.
Deposit date:2002-05-03
Release date:2002-06-19
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:CRYSTAL STRUCTURE AND MECHANISM OF A CALCIUM-GATED POTASSIUM CHANNEL
Nature, 417, 2002
1SDA
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CRYSTAL STRUCTURE OF PEROXYNITRITE-MODIFIED BOVINE CU,ZN SUPEROXIDE DISMUTASE
Descriptor:COPPER,ZINC SUPEROXIDE DISMUTASE, COPPER (II) ION, ZINC ION
Authors:Smith, C.D., Carson, M., Van Der Woerd, M., Chen, J., Ischiropoulos, H., Beckman, J.S.
Deposit date:1993-01-13
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of peroxynitrite-modified bovine Cu,Zn superoxide dismutase.
Arch.Biochem.Biophys., 299, 1992
6C04
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MTB RNAP HOLO/RBPA/DOUBLE FORK DNA -CLOSED CLAMP
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J., Lilic, M.
Deposit date:2017-12-27
Release date:2018-03-28
Method:ELECTRON MICROSCOPY (3.27 Å)
Cite:Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Elife, 7, 2018
6C05
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MYCOBACTERIUM TUBERCULOSIS RNAP HOLO/RBPA IN RELAXED STATE
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J., Lilic, M.
Deposit date:2017-12-27
Release date:2018-03-28
Method:ELECTRON MICROSCOPY (5.15 Å)
Cite:Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Elife, 7, 2018
6C06
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MYCOBACTERIUM TUBERCULOSIS RNAP HOLO/RBPA/FIDAXOMICIN
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J., Lilic, M.
Deposit date:2017-12-27
Release date:2018-03-28
Method:ELECTRON MICROSCOPY (5.15 Å)
Cite:Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Elife, 7, 2018
1FAP
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THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-RAPAMYCIN COMPLEX INTERACTING WITH HUMAN FRAP
Descriptor:FK506-BINDING PROTEIN, FRAP, RAPAMYCIN IMMUNOSUPPRESSANT DRUG
Authors:Choi, J., Chen, J., Schreiber, S.L., Clardy, J.
Deposit date:1996-03-15
Release date:1997-07-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP.
Science, 273, 1996
1G5K
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NMR STRUCTRURE OF D(CCAAAGXACTGGG), X IS A 3'-PHOSPHOGLYCOLATE, 5'-PHOSPHATE GAPPED LESION, 10 STRUCTURES
Descriptor:5'-D(*CP*CP*AP*AP*AP*G)-3', 5'-D(P*AP*CP*TP*GP*GP*G)-3', 5'-D(*CP*CP*CP*AP*GP*TP*AP*CP*TP*TP*TP*GP*G)-3', ...
Authors:Junker, H.-D., Hoehn, S.T., Bunt, R.C., Marathius, V., Chen, J., Turner, C.J., Stubbe, J.
Deposit date:2002-10-14
Release date:2003-01-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Synthesis, Characterization and Solution Structure of Tethered Oligonucleotides Containing an Internal 3'-Phosphoglycolate, 5'-Phosphate Gapped Lesion
Nucleic Acids Res., 30, 2002