3LDA | | YEAST RAD51 H352Y FILAMENT INTERFACE MUTANT | | Descriptor: | DNA repair protein RAD51, CHLORIDE ION | | Authors: | Villanueva, N.L., Chen, J., Morrical, S.W., Rould, M.A. | | Deposit date: | 2010-01-12 | | Release date: | 2010-04-21 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Insights into the mechanism of Rad51 recombinase from the structure and properties of a filament interface mutant.
Nucleic Acids Res., 38, 2010
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4XAX | | CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS CARD IN COMPLEX WITH THE THERMUS AQUATICUS RNA POLYMERASE BETA1 DOMAIN | | Descriptor: | DNA-directed RNA polymerase subunit beta domain 1, CarD, 1,2-ETHANEDIOL | | Authors: | Chen, J., Bae, B., Campbell, E.A., Darst, S.A. | | Deposit date: | 2014-12-15 | | Release date: | 2015-09-16 | | Last modified: | 2017-11-22 | | Method: | X-RAY DIFFRACTION (2.404 Å) | | Cite: | CarD uses a minor groove wedge mechanism to stabilize the RNA polymerase open promoter complex.
Elife, 4, 2015
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4MSU | | HUMAN GKRP BOUND TO AMG-6861 AND SORBITOL-6-PHOSPHATE | | Descriptor: | Glucokinase regulatory protein, 1,1,1,3,3,3-hexafluoro-2-{4-[4-(thiophen-2-ylsulfonyl)piperazin-1-yl]phenyl}propan-2-ol, D-SORBITOL-6-PHOSPHATE, ... | | Authors: | Ashton, K.S., Andrews, K.L., Bryan, M.C., Chen, J., Chen, K., Chen, M., Chmait, S., Croghan, M., Cupples, R., Fotsch, C., Helmering, J., Jordan, S.R., Kurzeja, R.J., Michelsen, K., Pennington, L.D., Poon, S.F., Sivits, G., Van, G., Vonderfecht, S.L., Wahl, R.C., Zhang, J., Lloyd, D.J., Hale, C., St Jean, D.J. | | Deposit date: | 2013-09-18 | | Release date: | 2014-03-12 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept.
J.Med.Chem., 57, 2014
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3PCU | | CRYSTAL STRUCTURE OF HUMAN RETINOIC X RECEPTOR ALPHA LIGAND-BINDING DOMAIN COMPLEXED WITH LX0278 AND SRC1 PEPTIDE | | Descriptor: | Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, 2-[(2S)-6-(2-methylbut-3-en-2-yl)-7-oxo-2,3-dihydro-7H-furo[3,2-g]chromen-2-yl]propan-2-yl acetate | | Authors: | Zhang, H., Zhang, Y., Shen, H., Chen, J., Li, C., Chen, L., Hu, L., Jiang, H., Shen, X. | | Deposit date: | 2010-10-22 | | Release date: | 2011-11-16 | | Last modified: | 2012-04-11 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | (+)-Rutamarin as a Dual Inducer of Both GLUT4 Translocation and Expression Efficiently Ameliorates Glucose Homeostasis in Insulin-Resistant Mice.
Plos One, 7, 2012
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3N3Y | | CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE X (THYX) FROM HELICOBACTER PYLORI WITH FAD AND DUMP AT 2.31A RESOLUTION | | Descriptor: | Thymidylate synthase thyX, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE | | Authors: | Wang, K., Wang, Q., Chen, J., Chen, L., Jiang, H., Shen, X. | | Deposit date: | 2010-05-21 | | Release date: | 2011-05-25 | | Last modified: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (2.307 Å) | | Cite: | Structure, Enzymatic Characterization and Inhibitor Discovery of Thymidylate Synthase X (ThyX) from Helicobacter pylori Strain SS1
To be Published
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3P30 | | CRYSTAL STRUCTURE OF THE CLUSTER II FAB 1281 IN COMPLEX WITH HIV-1 GP41 ECTODOMAIN | | Descriptor: | HIV-1 gp41, 1281 Fab light chain, 1281 Fab heavy chain | | Authors: | Frey, G., Chen, J., Rits-Volloch, S., Freeman, M.M., Zolla-Pazner, S., Chen, B. | | Deposit date: | 2010-10-04 | | Release date: | 2010-11-17 | | Last modified: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Distinct conformational states of HIV-1 gp41 are recognized by neutralizing and non-neutralizing antibodies.
Nat.Struct.Mol.Biol., 17, 2010
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3R29 | | CRYSTAL STRUCTURE OF RXRALPHA LIGAND-BINDING DOMAIN COMPLEXED WITH COREPRESSOR SMRT2 | | Descriptor: | Retinoic acid receptor RXR-alpha, Nuclear receptor corepressor 2 | | Authors: | Zhang, H., Chen, L., Chen, J., Jiang, H., Shen, X. | | Deposit date: | 2011-03-14 | | Release date: | 2011-05-25 | | Last modified: | 2011-07-27 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural basis for retinoic x receptor repression on the tetramer.
J.Biol.Chem., 286, 2011
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3R2A | | CRYSTAL STRUCTURE OF RXRALPHA LIGAND-BINDING DOMAIN COMPLEXED WITH COREPRESSOR SMRT2 AND ANTAGONIST RHEIN | | Descriptor: | Retinoic acid receptor RXR-alpha, Nuclear receptor corepressor 2, 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid | | Authors: | Zhang, H., Chen, L., Chen, J., Jiang, H., Shen, X. | | Deposit date: | 2011-03-14 | | Release date: | 2011-05-25 | | Last modified: | 2011-07-27 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural basis for retinoic x receptor repression on the tetramer.
J.Biol.Chem., 286, 2011
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3R5M | | CRYSTAL STRUCTURE OF RXRALPHALBD COMPLEXED WITH THE AGONIST MAGNOLOL | | Descriptor: | Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, 5,5'-di(prop-2-en-1-yl)biphenyl-2,2'-diol | | Authors: | Zhang, H., Chen, L., Chen, J., Hu, L., Jiang, H., Shen, X. | | Deposit date: | 2011-03-18 | | Release date: | 2012-02-08 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Molecular determinants of magnolol targeting both RXR(alpha) and PPAR(gamma).
Plos One, 6, 2011
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3R5N | | CRYSTAL STRUCTURE OF PPARGAMMALBD COMPLEXED WITH THE AGONIST MAGNOLOL | | Descriptor: | Peroxisome proliferator-activated receptor gamma, 5,5'-di(prop-2-en-1-yl)biphenyl-2,2'-diol | | Authors: | Zhang, H., Chen, L., Chen, J., Hu, L., Jiang, H., Shen, X. | | Deposit date: | 2011-03-18 | | Release date: | 2012-02-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Molecular determinants of magnolol targeting both RXR(alpha) and PPAR(gamma).
Plos One, 6, 2011
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4JBW | | CRYSTAL STRUCTURE OF E. COLI MALTOSE TRANSPORTER MALFGK2 IN COMPLEX WITH ITS REGULATORY PROTEIN EIIAGLC | | Descriptor: | Maltose transport system permease protein MalF, Maltose transport system permease protein MalG, Maltose/maltodextrin import ATP-binding protein MalK, ... | | Authors: | Chen, S., Oldham, M.L., Davidson, A.L., Chen, J. | | Deposit date: | 2013-02-20 | | Release date: | 2013-06-12 | | Last modified: | 2013-07-17 | | Method: | X-RAY DIFFRACTION (3.913 Å) | | Cite: | Carbon catabolite repression of the maltose transporter revealed by X-ray crystallography.
Nature, 499, 2013
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4KHZ | | CRYSTAL STRUCTURE OF THE MALTOSE-BINDING PROTEIN/MALTOSE TRANSPORTER COMPLEX IN AN PRE-TRANSLOCATION CONFORMATION BOUND TO MALTOHEPTAOSE | | Descriptor: | Maltose-binding periplasmic protein, Maltose transport system permease protein MalF, Binding-protein-dependent transport systems inner membrane component, ... | | Authors: | Oldham, M.L., Chen, S., Chen, J. | | Deposit date: | 2013-05-01 | | Release date: | 2013-10-23 | | Last modified: | 2013-11-27 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural basis for substrate specificity in the Escherichia coli maltose transport system.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4KI0 | | CRYSTAL STRUCTURE OF THE MALTOSE-BINDING PROTEIN/MALTOSE TRANSPORTER COMPLEX IN AN OUTWARD-FACING CONFORMATION BOUND TO MALTOHEXAOSE | | Descriptor: | ABC transporter related protein, Maltose-binding periplasmic protein, Maltose transport system permease protein MalF, ... | | Authors: | Oldham, M.L., Chen, S., Chen, J. | | Deposit date: | 2013-05-01 | | Release date: | 2013-10-23 | | Last modified: | 2013-11-27 | | Method: | X-RAY DIFFRACTION (2.38 Å) | | Cite: | Structural basis for substrate specificity in the Escherichia coli maltose transport system.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4R29 | | CRYSTAL STRUCTURE OF BACTERIAL CYSTEINE METHYLTRANSFERASE EFFECTOR NLEE | | Descriptor: | Uncharacterized protein, S-ADENOSYLMETHIONINE, GLYCEROL, ... | | Authors: | Yao, Q., Chen, J., Hu, L., Zhang, L., Shao, F. | | Deposit date: | 2014-08-11 | | Release date: | 2014-12-03 | | Last modified: | 2017-11-22 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Structure and Specificity of the Bacterial Cysteine Methyltransferase Effector NleE Suggests a Novel Substrate in Human DNA Repair Pathway.
Plos Pathog., 10, 2014
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2QYU | | CRYSTAL STRUCTURE OF SALMONELLA EFFECTOR PROTEIN SOPA | | Descriptor: | Secreted effector protein, PHOSPHATE ION, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | | Authors: | Diao, J., Chen, J. | | Deposit date: | 2007-08-15 | | Release date: | 2007-12-11 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structure of SopA, a Salmonella effector protein mimicking a eukaryotic ubiquitin ligase.
Nat.Struct.Mol.Biol., 15, 2008
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2QZA | | CRYSTAL STRUCTURE OF SALMONELLA EFFECTOR PROTEIN SOPA | | Descriptor: | Secreted effector protein | | Authors: | Diao, J., Chen, J. | | Deposit date: | 2007-08-16 | | Release date: | 2007-12-11 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structure of SopA, a Salmonella effector protein mimicking a eukaryotic ubiquitin ligase.
Nat.Struct.Mol.Biol., 15, 2008
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1BBU | | LYSYL-TRNA SYNTHETASE (LYSS) COMPLEXED WITH LYSINE | | Descriptor: | PROTEIN (LYSYL-TRNA SYNTHETASE), LYSINE | | Authors: | Onesti, S., Desogus, G., Brevet, A., Chen, J., Plateau, P., Blanquet, S., Brick, P. | | Deposit date: | 1998-04-24 | | Release date: | 2000-11-10 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural studies of lysyl-tRNA synthetase: conformational changes induced by substrate binding.
Biochemistry, 39, 2000
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1BBW | | LYSYL-TRNA SYNTHETASE (LYSS) | | Descriptor: | PROTEIN (LYSYL-TRNA SYNTHETASE) | | Authors: | Onesti, S., Desogus, G., Brevet, A., Chen, J., Plateau, P., Blanquet, S., Brick, P. | | Deposit date: | 1998-04-24 | | Release date: | 2000-11-10 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural studies of lysyl-tRNA synthetase: conformational changes induced by substrate binding.
Biochemistry, 39, 2000
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1LNQ | | CRYSTAL STRUCTURE OF MTHK AT 3.3 A | | Descriptor: | POTASSIUM CHANNEL RELATED PROTEIN, CALCIUM ION | | Authors: | Jiang, Y., Lee, A., Chen, J., Cadene, M., Chait, B.T., Mackinnon, R. | | Deposit date: | 2002-05-03 | | Release date: | 2002-06-19 | | Last modified: | 2014-11-12 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | CRYSTAL STRUCTURE AND MECHANISM OF A CALCIUM-GATED POTASSIUM CHANNEL
Nature, 417, 2002
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1SDA | | CRYSTAL STRUCTURE OF PEROXYNITRITE-MODIFIED BOVINE CU,ZN SUPEROXIDE DISMUTASE | | Descriptor: | COPPER,ZINC SUPEROXIDE DISMUTASE, COPPER (II) ION, ZINC ION | | Authors: | Smith, C.D., Carson, M., Van Der Woerd, M., Chen, J., Ischiropoulos, H., Beckman, J.S. | | Deposit date: | 1993-01-13 | | Release date: | 1993-10-31 | | Last modified: | 2017-11-29 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of peroxynitrite-modified bovine Cu,Zn superoxide dismutase.
Arch.Biochem.Biophys., 299, 1992
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6C04 | | MTB RNAP HOLO/RBPA/DOUBLE FORK DNA -CLOSED CLAMP | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J., Lilic, M. | | Deposit date: | 2017-12-27 | | Release date: | 2018-03-28 | | Method: | ELECTRON MICROSCOPY (3.27 Å) | | Cite: | Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Elife, 7, 2018
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6C05 | | MYCOBACTERIUM TUBERCULOSIS RNAP HOLO/RBPA IN RELAXED STATE | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J., Lilic, M. | | Deposit date: | 2017-12-27 | | Release date: | 2018-03-28 | | Method: | ELECTRON MICROSCOPY (5.15 Å) | | Cite: | Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Elife, 7, 2018
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6C06 | | MYCOBACTERIUM TUBERCULOSIS RNAP HOLO/RBPA/FIDAXOMICIN | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J., Lilic, M. | | Deposit date: | 2017-12-27 | | Release date: | 2018-03-28 | | Method: | ELECTRON MICROSCOPY (5.15 Å) | | Cite: | Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Elife, 7, 2018
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1FAP | | THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-RAPAMYCIN COMPLEX INTERACTING WITH HUMAN FRAP | | Descriptor: | FK506-BINDING PROTEIN, FRAP, RAPAMYCIN IMMUNOSUPPRESSANT DRUG | | Authors: | Choi, J., Chen, J., Schreiber, S.L., Clardy, J. | | Deposit date: | 1996-03-15 | | Release date: | 1997-07-23 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP.
Science, 273, 1996
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1G5K | | NMR STRUCTRURE OF D(CCAAAGXACTGGG), X IS A 3'-PHOSPHOGLYCOLATE, 5'-PHOSPHATE GAPPED LESION, 10 STRUCTURES | | Descriptor: | 5'-D(*CP*CP*AP*AP*AP*G)-3', 5'-D(P*AP*CP*TP*GP*GP*G)-3', 5'-D(*CP*CP*CP*AP*GP*TP*AP*CP*TP*TP*TP*GP*G)-3', ... | | Authors: | Junker, H.-D., Hoehn, S.T., Bunt, R.C., Marathius, V., Chen, J., Turner, C.J., Stubbe, J. | | Deposit date: | 2002-10-14 | | Release date: | 2003-01-07 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | Synthesis, Characterization and Solution Structure of Tethered Oligonucleotides Containing an Internal 3'-Phosphoglycolate, 5'-Phosphate Gapped Lesion
Nucleic Acids Res., 30, 2002
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